Gene Information

Name : Amuc_0836 (Amuc_0836)
Accession : YP_001877450.1
Strain : Akkermansia muciniphila ATCC BAA-835
Genome accession: NC_010655
Putative virulence/resistance : Virulence
Product : ATP-dependent chaperone ClpB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 986447 - 989029 bp
Length : 2583 bp
Strand : +
Note : KEGG: hau:Haur_4974 ATPase AAA-2 domain protein; TIGRFAM: ATP-dependent chaperone ClpB; PFAM: ATPase AAA; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase

DNA sequence :
ATGCTTAACAATCTAACAACAAAATTTCAGGAAGCGCTGATGCAGGCGCAGCAAACTGCAGGACGGCTTGGAAAACCGGA
AATCTCCTCTCTGGACGTTCTGGTGGCGTTGCTGGAGCAGGAAGGCGGAATTCTTTCCCCTATTCTCCGCAAGGCCTCTT
GCGACCCGGGGTTGTTTCTCCAGGCGGCCCAGAGGGAAGTTTCCCACGAACCTACCCAAAGCGGTGCCACCACCCAGCCC
CAGATGGGGCGTGACCTGGCTACGGTAATGCAGGCTGCGGAAGAAGAACGCAAAAAGCTCAAAGATGACTACCTCAGCGT
GGAACATTTCATGCTTGGTGCGTTGGACACGCAAAACAAAGTGCACCAGTTGACGGACACCTTTGGCCTGACCAAGGATA
ATTATCTGGCCGCCATGAAAGAAGTGCGCGGCAACCAGCGCGTGACGGACGATAATCCGGAAGGCAAATACCAGACGCTG
GAAAAATATGGAACGGACCTGACGGCCCGCGCCCGTGCCGGTAAAATTGACCCTGTTATCGGCCGCGATACGGAAATCCG
CCGTGTTTTGCAGATTCTTTCCCGCAGGACGAAAAACAATCCCGTCCTGATCGGGGAACCCGGCGTTGGTAAAACCGCCA
TTGCGGAAGGTTTGGCGCGGCGCATAGTCAACGGCGACGTGCCGGAAAGCATGCGCAACAAGCGCATTGTTTCGCTCAAC
ATCGGATCCATGCTCGCCGGGGCCAAATATCGTGGCGAATTTGAAGAGCGCTTGAAATCCTTCCTTAAGGAAGTAACGGA
TTCCAACGGTGAAATCATTCTATTTATTGATGAACTGCACACCATCGTAGGCGCGGGCGCCAGTGAAGGGGCGGTGGATG
CGTCCAACCTGCTCAAACCCGCCCTGGCCCGCGGGGAACTGCGGACCATCGGCGCGACGACACTGGACGAATACCGCAAA
TACATTGAAAAGGATGCGGCTCTGGAACGCCGGTTTCAGCCCGTCATGGTCTCCGAGCCCAGCGTGGAAGATACCATTGC
CATCCTGCGCGGCCTGAAAGAACGCTATGAAGTTCACCATGGGGTGCGTATTACGGACGCTGCCATCGTGGCGGCCGCCA
CCCTTTCCGACCGTTATATTTCCGACCGTTTTCTGCCTGACAAGGCAGTGGATCTGGTGGATGAAGCGGCAGCCCGCCTC
AAAATTGAGCTGGACTCCATGCCCACGGAAATTGACCAGATTGAACGTGAAGCCATGCAGCTTGAAATGGAGCGGCAGGC
GCTGGCGAAGGAAGAAGACGCCGACAGCAAGGCGCGTTTGGAAAAAATCACCAAGGACCTGGCCGATTTGAAGGAAAAAT
CCGGTTCCATGATTGCCAAATGGAAAAGTGAAAAGGAAGTGCTGGACGCCGTCCGCAGGGAACAGGAAAAAATAGAAGCC
CTCAAGCTGGAAAGTGAACGGGCCAAACGGATGGGTGATCTGACCCGCGCATCGGAAATCACCTATGGCGAACTTCCGGA
GGCCCAGCGCGCCCTGGCGGAAGGCAAGGAAAAGCTCAGTAAAATGCAGAAGGAAGATGGAGGGCTGCTGAAGGAGGAAG
TCACGGAAGGAGACATCGCCAAAGTGGTTGCCACCTGGACCGGCATCCCCGCCGCCCGTCTGCAGGAAGGGGAGCGTGCC
AAGCTGGTGCACATGGAAGAACGTCTGGGCGCCCGCGTAATCGGGCAGAAACAGGCCGTTAAGGCCGTATCCGACGCCGT
GAGGCGCGCCCGCGCCGGGTTGCAGGATGAAAACAGGCCCATTGGCTCTTTCCTGTTCCTGGGACCCACCGGCGTCGGCA
AGACGGAGCTCAGCAAGGCACTGGCGGAATTCCTTTTTGACAATGAAAACGCCATCGTCCGCATTGACATGTCCGAATAC
ATGGAAAAACATTCTGTTGCGCGCCTCATCGGGGCGCCTCCCGGATACGTGGGGTATGAAGAAGGCGGTCAGCTCTCTGA
GGCCGTGCGGCGCCGTCCGTACTGCGTGGTTCTCTTCGATGAAATTGAAAAGGCCCACCCGGACGTCTTCAACGTATTGC
TCCAGGTATTGGACGACGGCCGTATTACGGACGGCCAGGGGCGTACGGTTGACTTCCGCAACACGGTCATCATCATGACC
TCCAACATCGGCAGCCAGTATATCCTCAATGAAGCCAATGCGGAACAGCGGGAAGCCAAGGCCCTGGAGGCGTTGCGAGG
CCACTTCCGTCCGGAATTCCTGAACCGCATTGATGAAATCATCATCTTTGACCGGCTCACGGCGCAGGAACTCAAGGGCA
TTGTGGACATTCAGCTTCAGCGTGTCCGCAGGCGCCTGGAAGCCAAAGGCCTGTTTTTGCGCATGACTCCGGAAGCTACG
GCTCTGGTGGCGGATCACGGTTTTGATCCTGTTTATGGAGCCCGGCCTCTCAAGCGGGCCATCCAGCATGATCTTCTGGA
CCCGCTCAGCCTTAAACTTCTGGAAGGGGACTTCCCGGAAGGAACGGAAATCGTGGTGCGGGAAAAAGGCGGCAAATTGG
ACTTCACCAAGGAGAAAAAATAA

Protein sequence :
MLNNLTTKFQEALMQAQQTAGRLGKPEISSLDVLVALLEQEGGILSPILRKASCDPGLFLQAAQREVSHEPTQSGATTQP
QMGRDLATVMQAAEEERKKLKDDYLSVEHFMLGALDTQNKVHQLTDTFGLTKDNYLAAMKEVRGNQRVTDDNPEGKYQTL
EKYGTDLTARARAGKIDPVIGRDTEIRRVLQILSRRTKNNPVLIGEPGVGKTAIAEGLARRIVNGDVPESMRNKRIVSLN
IGSMLAGAKYRGEFEERLKSFLKEVTDSNGEIILFIDELHTIVGAGASEGAVDASNLLKPALARGELRTIGATTLDEYRK
YIEKDAALERRFQPVMVSEPSVEDTIAILRGLKERYEVHHGVRITDAAIVAAATLSDRYISDRFLPDKAVDLVDEAAARL
KIELDSMPTEIDQIEREAMQLEMERQALAKEEDADSKARLEKITKDLADLKEKSGSMIAKWKSEKEVLDAVRREQEKIEA
LKLESERAKRMGDLTRASEITYGELPEAQRALAEGKEKLSKMQKEDGGLLKEEVTEGDIAKVVATWTGIPAARLQEGERA
KLVHMEERLGARVIGQKQAVKAVSDAVRRARAGLQDENRPIGSFLFLGPTGVGKTELSKALAEFLFDNENAIVRIDMSEY
MEKHSVARLIGAPPGYVGYEEGGQLSEAVRRRPYCVVLFDEIEKAHPDVFNVLLQVLDDGRITDGQGRTVDFRNTVIIMT
SNIGSQYILNEANAEQREAKALEALRGHFRPEFLNRIDEIIIFDRLTAQELKGIVDIQLQRVRRRLEAKGLFLRMTPEAT
ALVADHGFDPVYGARPLKRAIQHDLLDPLSLKLLEGDFPEGTEIVVREKGGKLDFTKEKK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
aec27 YP_851418.1 ATPase Not tested PAI II APEC-O1 Protein 5e-111 43
aec27 AAQ96721.1 Aec27 Not tested AGI-1 Protein 4e-111 43
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 2e-109 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Amuc_0836 YP_001877450.1 ATP-dependent chaperone ClpB VFG0079 Protein 4e-159 45
Amuc_0836 YP_001877450.1 ATP-dependent chaperone ClpB VFG2076 Protein 2e-117 44
Amuc_0836 YP_001877450.1 ATP-dependent chaperone ClpB VFG2084 Protein 4e-110 43