Gene Information

Name : guaA (Npun_R0710)
Accession : YP_001864405.1
Strain : Nostoc punctiforme PCC 73102
Genome accession: NC_010628
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 840709 - 842331 bp
Length : 1623 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAATACAGTGGTGACTCTACCGACAGAACAAGCGCCCCAAACATTGGAAAATGTTGGGCGGTTTGATCGCCCATTAAT
TATAATTCTGGACTTCGGCTCTCAATATTCTGAGTTGATTGCCCGCCGCATCCGCGAGACTCAAGTATACTCTGAAGTTT
TATCCTATCGCACTACTTCTGAACAATTGCGCCAACTCAATCCCAAGGGAATTATCCTCTCTGGTGGACCGAGTTCGGTT
TATGGTGACAACGCTCCTCATTGCGATCCTGAAATCTGGAATTTAGGAATACCCGTCTTGGGTGTTTGCTATGGGATGCA
GCTAATGGTAAACCAACTCGGTGGCGAAGTTGCAAAGGCTGACCGAGGTGAGTACGGCAAAGCCTCATTATATATTGACG
ATCCCACAGATTTGCTCACTAATGTTGAAGATGGTACCACGATGTGGATGAGTCACGGAGACTCAGTTACCCAAATGCCA
TCAGGGTTTGAATTGCTGGCACATACAGAAAATACCCCCTGTGCTGCGATCGCTGACCACGAAAGGAAACTTTACGGCGT
TCAATTCCATCCAGAGGTGGTGCATTCTATTGGTGGCATAGCATTAATTCGTAATTTTGTCTACCATATCTGCGATTGCG
AACCCACTTGGACAACTGCGGCTTTTGTTGAAGAGGCAATTCGGGAAATTCGCACCAGAGTTGGCGAGAAGCGAGTGCTT
TTGGCACTATCTGGGGGAGTTGATTCTTCTACCCTGGCGTTCTTACTGTATAAAGCCATTGGCGAGCAACTAACTTGTGT
GTTTATCGATCAAGGCTTTATGCGAAAGTATGAGCCAGAGCGATTAGTAAAGCTGTTCCAAGAGCAGTTTCACATTCCTG
TAGAGTATGTGAATGCCCGCGATCGCTTTTTAGCTAAGGTTGCTGGTGTTACGGATCCTGAAGAAAAACGCCGCCGCATC
GGACACGAATTTATCAATGTATTTGAGGAAACATCCAAGCGCCTTGGTCATTTTGACTATCTAGCTCAAGGCACTCTTTA
TCCAGATGTCATCGAATCTGCTGACACCAACGCCGATCCTCAAACTGGTGAGCGGGTAGCGGTGAAAATTAAGAGCCATC
ATAATGTTGGCGGTTTACCCAAAGACCTAAGATTTAAATTGGTGGAACCACTGCGGAAATTATTTAAAGATGAAGTCCGC
AAAGTTGGGCGTTCCATTGGTTTACCAGAAGAAATTGTCCAACGACAACCTTTTCCTGGGCCTGGTTTGGCAATTCGCAT
TTTGGGGGAAGTTACATCTGAGCGGTTAAATATTTTGCGCGATGCTGATTTGATTGTGCGGCAAGAAATTAACCAACGCG
GTATGTATCATGATTTCTGGCAAGCATTTGCTGTATTGCTGCCAATCCGTAGTGTTGGCGTTATGGGCGATCAACGTACT
TACGCTTACCCCATTGTCTTGCGAATTGTTACCAGTGAAGATGGCATGACTGCTGATTGGGCGAGAGTGCCTTACGATGT
CCTGGAAGTGATTTCCACGCGGATTGTAAATGAAGTGAAAGGGGTGAATCGGGTGGTTTATGACATCACCTCTAAGCCGC
CTGGAACCATTGAATGGGAGTAA

Protein sequence :
MNTVVTLPTEQAPQTLENVGRFDRPLIIILDFGSQYSELIARRIRETQVYSEVLSYRTTSEQLRQLNPKGIILSGGPSSV
YGDNAPHCDPEIWNLGIPVLGVCYGMQLMVNQLGGEVAKADRGEYGKASLYIDDPTDLLTNVEDGTTMWMSHGDSVTQMP
SGFELLAHTENTPCAAIADHERKLYGVQFHPEVVHSIGGIALIRNFVYHICDCEPTWTTAAFVEEAIREIRTRVGEKRVL
LALSGGVDSSTLAFLLYKAIGEQLTCVFIDQGFMRKYEPERLVKLFQEQFHIPVEYVNARDRFLAKVAGVTDPEEKRRRI
GHEFINVFEETSKRLGHFDYLAQGTLYPDVIESADTNADPQTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVR
KVGRSIGLPEEIVQRQPFPGPGLAIRILGEVTSERLNILRDADLIVRQEINQRGMYHDFWQAFAVLLPIRSVGVMGDQRT
YAYPIVLRIVTSEDGMTADWARVPYDVLEVISTRIVNEVKGVNRVVYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-141 56
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-141 56
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-141 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-130 53