Gene Information

Name : guaA (Bphy_1312)
Accession : YP_001857540.1
Strain :
Genome accession: NC_010622
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1470105 - 1471688 bp
Length : 1584 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCATGACAAGATCCTGATTCTCGACTTTGGTTCGCAAGTCACCCAACTGATCGCACGCCGCATTCGCGAAGCGCACGT
GCTGTCGGAAATCCATCCGCACGACGTCAGCGACGAATTCATTCGCGACTTCAAGCCGACGGGCATCATCCTGTCGGGTG
GCCCGAACTCGGTCACCGAGACGGACACGCCGCGCGCGCCGCAGGCGGTGTTCGAGGCTGGCGTGCCCGTGCTAGGCATC
TGCTACGGCATGCAGACGATGGCCGAGCAGCTGGGCGGCAAGGTCGACAGCGGCCACCTGCGCGAATTCGGCTACGCGGA
AGTGCGCGCGCGCAATCACACGAGCTTCCTCGACGGCATTCAGGACTTCGCGACGCCCGAAGGCCACGGCATGCTGAAGG
TGTGGATGAGCCACGGCGACAAGGTGCTGGAAATGCCGCAAGGCTTCCAGCTGATGGCATCGACGGAATCGTGCCCGATT
GCTGCGATGGCTGACGAGACGCGCCATTTCTACGGCGTGCAGTGGCACCCGGAAGTCACGCATACGGTGCAGGGCCGCGC
GATGCTCGAACGCTTCGTGCTGAAGATTTGCGGCGCGAAGCCCGACTGGGAAATGGGCAACTACATCGACGAAGCGGTTG
AAAACATCCGCAAACAGGTCGGCGACGAGCATGTGATTCTCGGTCTGTCGGGCGGCGTCGATTCGTCGGTGGCGGCGGCG
CTGTTGCATCGCGCGATCGGCGATCAGCTGACCTGCGTGTTCGTCGATCACGGTTTGCTGCGCCTGAATGAAGCCGAGCA
GGTGATGTCGATGTTCGCGGACAACCTCGGCGTGAAGGTGATCCATGTCGACGCCAGCGAAGCGTTCATGTCGAAGCTCA
AGGGTGTGACGGATCCGGAAGCGAAGCGCAAGATCATCGGCGCGGAATTCGTCGAAGTGTTCCAGACGGAAGCGGGCAAG
CTGACGGACGCGAAATGGCTCGCGCAAGGGACGATCTATCCGGACGTGATCGAATCGGCGGGCAAGGGCAAGAAGGCCGC
GCACACGATCAAGAGCCATCACAACGTCGGCGGCCTGCCGGAAACGCTGAACCTCAAGCTGCTCGAACCGCTGCGCGAAC
TCTTCAAGGACGAAGTGCGGGAACTGGGCGTGAAGTTGGGTTTGCCGCCTTCGATGGTGTATCGCCATCCGTTCCCGGGC
CCTGGCCTCGGCGTGCGGATTCTTGGCGAAGTGAAGCGCGAATACGCCGATCTGCTGCGCCGCGCGGACGCGATCTTCAT
CGAATCCCTGCGCACGTTTATCGACAAGGACACGGACAAGTCGTGGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCC
TGCCTGTGAAGAGCGTCGGTGTGATGGGCGACGGACGCACGTATGAATATGTTGTCGCGCTGCGCGCCGTCCAGACGCTC
GACTTCATGACGGCGCACTGGGCGCATCTGCCGCACGATCTGCTCGGCCATGTGTCGAATCGGATCATTAATGAGGTGCG
CGGCATCAATCGTGTCGTGTACGACATCTCGGGCAAGCCGCCTGCGACGATTGAGTGGGAGTGA

Protein sequence :
MHDKILILDFGSQVTQLIARRIREAHVLSEIHPHDVSDEFIRDFKPTGIILSGGPNSVTETDTPRAPQAVFEAGVPVLGI
CYGMQTMAEQLGGKVDSGHLREFGYAEVRARNHTSFLDGIQDFATPEGHGMLKVWMSHGDKVLEMPQGFQLMASTESCPI
AAMADETRHFYGVQWHPEVTHTVQGRAMLERFVLKICGAKPDWEMGNYIDEAVENIRKQVGDEHVILGLSGGVDSSVAAA
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMSMFADNLGVKVIHVDASEAFMSKLKGVTDPEAKRKIIGAEFVEVFQTEAGK
LTDAKWLAQGTIYPDVIESAGKGKKAAHTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRELGVKLGLPPSMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIESLRTFIDKDTDKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
DFMTAHWAHLPHDLLGHVSNRIINEVRGINRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-122 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-122 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-122 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-104 50