Gene Information

Name : putA_1 (MMAR_0780)
Accession : YP_001849095.1
Strain : Mycobacterium marinum M
Genome accession: NC_010612
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase, PutA
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : -
Position : 938575 - 940098 bp
Length : 1524 bp
Strand : +
Note : interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]

DNA sequence :
ATGACCGTGTTTGCACGTCCGGGTTCGGCCGGGGCGCTGATGTCGTTTGAGTCCCGGTACGGAAATTTCATCGGGGGTGA
GTGGGTTGCCCCGGCGCGGGGCCGCTACTTCGAAGACCTGACCCCGGTGACCGGCCAGCCATTTTGCGAGATACCGCGCT
CTGATGAGGCCGATGTCGAGATGGCGCTCGACGCCGCACATGCGGCGGCCCCGGCCTGGGGCAAGATGGCCCCGGCCGAG
CGAGCCGCGATCCTGAACAAGATCGCCGACCGGATCGATGAAAACAGGGCCGCGCTGGCGGTGGCCGAAGTCTGGGACAA
CGGCAAACCGGTCCGAGAGGCAATAGCCGCTGACATCCCGCTGGCGGCGGATCACTTCCGCTACTTCGCAGCGGCGATCC
GGGCCCAGGAAGGTTCGCTGTCGCAGATCGATCAGGACACGGTCGCCTACCACTTTCACGAGCCGCTCGGGGTGGTGGGG
CAGATCATTCCGTGGAACTTCCCGATCCTGATGGGTGCTTGGAAGCTGGCGCCGGCGCTGGCGGCCGGTAACGCGGTGGT
GCTCAAACCCGCGGAGCAGACGCCCGCGTCGGTGCTGTACCTGATGTCGCTGATCGGCGACCTATTGCCGCCCGGGGTGG
TCAACGTCGTCAATGGTTTCGGCGCCGAAGCGGGCAAGCCGCTGGCGTCCAGCAACCGAATTGCCAAGGTCGCGTTCACC
GGAGAGACCACCACCGGGCGCCTGATCATGCAGTACGCCTCACAAAACCTGATCCCGGTAACCCTGGAACTCGGCGGCAA
GAGCCCCAACATCTTCTTTTCTGATGTGATGGCCAAGCCCGACGACTTCCAGGACAAGGCGCTGGAGGGTTTCACGATGT
TCGCCCTCAACCAGGGCGAGGTGTGTACCTGTCCGTCGCGCAGCCTGATCCAGGCCGACATCTACGACGAGTTCCTGGAA
CTGGCGGCGATCCGGACCAAGGCGGTTCGGCAGGGCGATCCCTTGAACATCGAGACGATGCTGGGGTCACAGGCCTCCAA
CGACCAGCTGGAAAAGGTGTTGTCCTACATCGAAATCGGCAAGGAAGAGGGCGCCAAGGTCATTACCGGCGGCGAGCGCG
CCGAACTCGGTGGTGACCTGTCCGGCGGCTTTTACATGCAGCCGACGATCTTCAGCGGCACCAACAAGATGCGGATCTTC
CAGGAGGAGATATTCGGTCCGGTGGTGGCGGTCACGCCGTTCACCGACTACGACGACGCGATGGGTATCGCCAACGACAC
CCTCTACGGGTTGGGGGCGGGGGTGTGGAGCCGCGACGGCAACACGGCCTACCGGGCCGGCCGGGACATCCAGGCGGGCC
GGGTGTGGGTCAACTGCTATCACGTCTACCCGGCGCACTCGGCGTTCGGTGGCTACAAGCAGTCCGGCATTGGCCGGGAA
GGCCATCAGATGATGCTGGGCCACTATCAGCAGACCAAGAACCTGTTGGTGTCCTACTCGGATAAGGCTTTGGGGTTGTT
CTGA

Protein sequence :
MTVFARPGSAGALMSFESRYGNFIGGEWVAPARGRYFEDLTPVTGQPFCEIPRSDEADVEMALDAAHAAAPAWGKMAPAE
RAAILNKIADRIDENRAALAVAEVWDNGKPVREAIAADIPLAADHFRYFAAAIRAQEGSLSQIDQDTVAYHFHEPLGVVG
QIIPWNFPILMGAWKLAPALAAGNAVVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVNGFGAEAGKPLASSNRIAKVAFT
GETTTGRLIMQYASQNLIPVTLELGGKSPNIFFSDVMAKPDDFQDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLE
LAAIRTKAVRQGDPLNIETMLGSQASNDQLEKVLSYIEIGKEEGAKVITGGERAELGGDLSGGFYMQPTIFSGTNKMRIF
QEEIFGPVVAVTPFTDYDDAMGIANDTLYGLGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHVYPAHSAFGGYKQSGIGRE
GHQMMLGHYQQTKNLLVSYSDKALGLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 5e-134 59
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 3e-141 58
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 3e-141 58
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 3e-141 58
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-140 58
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 6e-64 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
putA_1 YP_001849095.1 aldehyde dehydrogenase, PutA VFG0082 Protein 2e-134 59