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Name : ethA (MMAR_5404) Accession : YP_001853664.1 Strain : Mycobacterium marinum M Genome accession: NC_010612 Putative virulence/resistance : Unknown Product : monooxygenase EthA Function : - COG functional category : P : Inorganic ion transport and metabolism COG ID : COG2072 EC number : - Position : 6535699 - 6537168 bp Length : 1470 bp Strand : - Note : activates the pro-drug ethionamide (eth); induced eth sensitivity when overexpressed in mycobacterium tuberculosis DNA sequence : ATGACTGAGCATCTTGACGTCGTGATCGTGGGGGCGGGTATCTCCGGCGTGAGTGCAGCCTGGCATCTTCAAGACCGCTG TCCGACCAAGTCCTACGCGATCCTGGAGAAGCGCGCCGCCATGGGTGGCACCTGGGATCTGTTCCGCTACCCCGGCATCC GATCCGACTCCGATATGCACACGCTGGGCTTCCGCTTTCGTCCGTGGACCGAGCGCCAGGCCATCGCCGACGGCAAGCCG ATCCTCGAATACGTCAAAGGCACGGCGGCCATGTACGGCATCGACAAGCACATCCGGCTCAACCAGAAAGTCATCAGCGC GGACTGGTCGAACGCGCAGAACCGCTGGACGCTGCAGATCGAGAGCAACGGTGCCACGAGCGCCGTCACCTGTTCGTTCC TGTTTCTCTGCAGCGGCTACTACAACTACGACCAGGGCTACACCCCGAACTTCGCCGGTGCGCAGGACTTCGCCGGCTCG ATCATCCATCCGCAGCACTGGCCCGAAGACCTCGACTATGACGGCAAGAACGTCGTCGTGATCGGCAGCGGTGCCACCGC GGTCACTCTGGTCCCGGCGCTGGCGAACTCGGGGGCCAAGCACGTCACGATGCTGCAGCGCTCGCCGACCTACATCGTCT CCCAGCCAGAACGGGACAGCATCGCTGAGCGCCTCAACCGCTGGCTTCCCGAGAACATGGCCTACGCCATGGTGCGGTGG AAGAACGTGCTGCGCCAGGCCGCCGTATACGGAGCCTGCCGCAAGTGGCCGCGGCGAATGCGGAAGAACTTCATGGGACT GGCCCAGCGTCAGTTGCCCGAAGGCTATGACGTGCGAAAGCATTTCGGCCCGCACTACAACCCATGGGACCAGCGGCTAT GCCTGGTGCCCAACGGCGACTTGTTCCGGGCCATTCGCCACGGACAGGTCGATGTGGTCACCGACACGATCGACCGGTTC ACGCCGACCGGCATCCGGCTCAACTCAGGCCAGCAGCTGCCGGCCGACATCATCGTCACCGCAACGGGTTTGAACCTGCA GCTCTTCGGCGGGGCGGCGGTCACCGTGGACGGAGAGTCGGTGGATCTCACCAAGGCGATGGCCTACAAGGGCATGATGC TTTCCGGCCTGCCCAACATGGCCTACACCGTTGGCTACACCAACGCGTCGTGGACACTGAAGGCGGATCTGGTGTCGGAG TTCGTGTGCCGTCTGCTCAACTACATGGACGCCAATGACTATGACTCCGTCGTCGTCGAGCGCCCGGGTTCGGATGTGCA GGAATGTCCCTTCATGGAGTTCACTCCGGGCTATGTGCTGCGCGTGATCGACGAACTTCCCAAGCAGGGTTCACGCAAGC CGTGGCGCCTCAACCAGAACTATCTGCGCGATATTCATCTGATTCGCCGCGGCAAGATCGACGACGAGGGTTTGCGATTC GCCAAAAAGCCGGTCGCAGTGCCGGTTTAG Protein sequence : MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRAAMGGTWDLFRYPGIRSDSDMHTLGFRFRPWTERQAIADGKP ILEYVKGTAAMYGIDKHIRLNQKVISADWSNAQNRWTLQIESNGATSAVTCSFLFLCSGYYNYDQGYTPNFAGAQDFAGS IIHPQHWPEDLDYDGKNVVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPERDSIAERLNRWLPENMAYAMVRW KNVLRQAAVYGACRKWPRRMRKNFMGLAQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGQVDVVTDTIDRF TPTGIRLNSGQQLPADIIVTATGLNLQLFGGAAVTVDGESVDLTKAMAYKGMMLSGLPNMAYTVGYTNASWTLKADLVSE FVCRLLNYMDANDYDSVVVERPGSDVQECPFMEFTPGYVLRVIDELPKQGSRKPWRLNQNYLRDIHLIRRGKIDDEGLRF AKKPVAVPV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| unnamed | AAK01510.1 | aromatic-ring hyroxylase | Not tested | PAGI-1 | Protein | 4e-121 | 54 |
