Gene Information

Name : clpC1 (MMAR_5100)
Accession : YP_001853359.1
Strain : Mycobacterium marinum M
Genome accession: NC_010612
Putative virulence/resistance : Virulence
Product : ATP-dependent protease ATP-binding subunit ClpC1
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 6178578 - 6181124 bp
Length : 2547 bp
Strand : -
Note : hydrolyses proteins in presence of ATP. may interact with a ClpP-like protease involved in degradation of denatured proteins

DNA sequence :
ATGTTCGAACGTTTTACCGACCGTGCCCGCCGGGTCGTTGTCCTGGCGCAAGAAGAGGCCCGGATGCTGAACCACAACTA
CATCGGCACCGAGCACATTCTGCTGGGGCTAATCCATGAAGGCGAAGGCGTTGCGGCCAAGTCGCTGGAGTCGCTCGGGA
TCTCGCTGGAAGGTGTGCGCAGCCAGGTCGAAGAGATCATCGGCCAGGGCCAGCAGGCACCGTCCGGGCACATCCCGTTC
ACTCCGCGCGCCAAGAAGGTGCTCGAACTCAGCCTGCGCGAGGCGCTGCAGCTCGGCCACAACTACATCGGTACCGAGCA
CATCCTGCTCGGCCTGATTCGCGAGGGCGAGGGTGTGGCCGCCCAGGTGCTGGTCAAGCTGGGCGCCGAACTGACCCGGG
TGCGCCAGCAGGTGATCCAGCTGCTGAGCGGCTACCAGGGCAAGGAGGCCGCCGAGGCAGGCACCGGCGGCCGGGGAGGG
GAGTCCGGCTCTCCCTCCACGTCGCTGGTTCTCGACCAGTTCGGCCGCAACCTGACCGCGGCTGCCATGGAAGGCAAGCT
GGACCCGGTCATCGGCCGCGAGAAGGAAATCGAGCGGGTCATGCAGGTGCTCTCCCGGCGCACCAAGAACAACCCGGTGC
TCATCGGTGAGCCCGGCGTGGGCAAGACCGCTGTGGTCGAGGGCCTGGCGCAGGCCATCGTGCACGGCGAGGTGCCCGAG
ACGCTGAAGGACAAGCAGCTCTACACGCTGGACCTCGGCTCGCTGGTCGCGGGTTCGCGCTACCGCGGTGACTTCGAGGA
ACGCCTGAAGAAGGTGCTCAAGGAGATCAATACCCGCGGCGACATCATCCTGTTCATCGACGAGCTGCACACGCTGGTCG
GGGCGGGTGCCGCCGAGGGCGCGATCGATGCCGCAAGCATCCTCAAGCCCAAGCTGGCTCGCGGCGAGCTGCAGACGATC
GGTGCCACCACCCTCGACGAGTACCGCAAGTACATCGAGAAGGACGCCGCGCTGGAGCGCCGTTTCCAGCCGGTGCAGGT
GGGGGAGCCGACGGTCGAGCACACCATCGAGATCCTCAAGGGCCTGCGGGACCGCTACGAGGCGCACCACCGCGTGTCGA
TCACCGATTCCGCGATGGTGGCCGCCGCGACGCTGGCCGACCGCTACATCAACGACCGGTTCCTGCCGGACAAGGCGATC
GACCTGATCGACGAGGCGGGCGCCCGGATGCGGATCCGTCGCATGACCGCGCCGCCAGACCTGCGCGAGTTCGACGAGAA
GATCGCCGACGCGCGCCGGGAGAAGGAATCGGCGATCGACGCCCAGGACTTCGAGAAGGCGGCGAGCCTGCGCGACCGGG
AGAAGCAACTGGTGGCGCAGCGTGCCGAGCGTGAAAAGCAATGGCGTTCGGGCGATCTCGACGTGGTCGCCGAAGTCGAT
GACGAACAGATCGCCGAAGTGCTGGGCAACTGGACTGGCATCCCGGTGTTCAAGCTCACCGAGGCGGAAACCACCCGCCT
GCTGCGGATGGAAGATGAGCTGCACAAGCGGATCATCGGCCAGGAAGACGCGGTCAAGGCGGTCTCCAAGGCGATCCGCC
GCACCCGCGCCGGGCTGAAGGACCCGAAGCGCCCGTCGGGATCGTTCATCTTCGCCGGCCCTTCCGGTGTCGGTAAGACC
GAGCTGTCCAAGGCGCTGGCCAACTTCTTGTTCGGTGACGACGACGCGCTCATCCAGATCGACATGGGCGAGTTCCACGA
CCGGTTCACCGCGTCCCGGCTCTTCGGTGCTCCGCCCGGATATGTCGGCTACGAAGAGGGCGGCCAGCTCACCGAGAAGG
TGCGGCGCAAGCCGTTCAGCGTGGTGCTCTTCGATGAGATCGAGAAGGCACACCAGGAGATCTACAACAGTCTGTTGCAG
GTCCTCGAGGACGGCCGGCTCACCGACGGCCAGGGCCGCACGGTCGACTTCAAGAACACCGTGCTGATCTTCACGTCGAA
TCTGGGGACATCCGATATTTCCAAGCCCGTCGGCCTCGGGTTCAGCCAGACTGGCGGCGAGAACGACTACGAGCGGATGA
AGCAGAAGGTCAACGACGAGCTCAAGAAGCACTTCCGGCCGGAGTTCCTCAACCGCATCGACGACATCATCGTCTTCCAC
CAGCTGACTCGCGACGAGATCATCCGGATGGTCGACCTGATGATCGGCCGCGTCGCCAACCAGCTCAAGAGCAAGGACAT
GGCGCTCGAGCTGACCGACAAGGCAAAGTCGCTGCTGGCCAAGCGCGGTTTCGACCCGGTCTTGGGTGCTCGTCCGCTGC
GGCGAACCATTCAGCGTGAGATCGAGGACCAGCTCTCGGAGAAGATCCTCTTCGAGGAGGTCGGTCCGGGACAGGTCGTC
ACCGTCGACGTCGACAACTGGGACGGCGAGGGCGCCGGTGAGGACGCGAAATTTACGTTCACCGGTACCCGCAAGCCGCC
GAGTGAGCCGGACCTGGCAAAGGCCGGAGCACACAGCGCCGGGGGACCTGGGCCCACCGAGCAGTAA

Protein sequence :
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVRSQVEEIIGQGQQAPSGHIPF
TPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGG
ESGSPSTSLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPE
TLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTI
GATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAI
DLIDEAGARMRIRRMTAPPDLREFDEKIADARREKESAIDAQDFEKAASLRDREKQLVAQRAEREKQWRSGDLDVVAEVD
DEQIAEVLGNWTGIPVFKLTEAETTRLLRMEDELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKT
ELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQ
VLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFSQTGGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFH
QLTRDEIIRMVDLMIGRVANQLKSKDMALELTDKAKSLLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVV
TVDVDNWDGEGAGEDAKFTFTGTRKPPSEPDLAKAGAHSAGGPGPTEQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 81

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC1 YP_001853359.1 ATP-dependent protease ATP-binding subunit ClpC1 VFG0079 Protein 0.0 60
clpC1 YP_001853359.1 ATP-dependent protease ATP-binding subunit ClpC1 VFG0080 Protein 1e-148 51