Gene Information

Name : MMAR_4912 (MMAR_4912)
Accession : YP_001853171.1
Strain : Mycobacterium marinum M
Genome accession: NC_010612
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : -
Position : 5967081 - 5968604 bp
Length : 1524 bp
Strand : -
Note : interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]

DNA sequence :
ATGACCGTGTTCGCACGTCCGGGCGCGCACAGTTCATTGATGACTTTCGAGTCCCGCTACGGCAACTTCATCGGCGGCGA
GTGGGTCGCGCCGGCCGCAGGCGAGTACTTCGAGGACCTAACCCCGGTAACCGGCGCACCGTTCTGCGAGGTGCCACGCT
CCACCGATGTCGATGTCGAAAAGGCACTCGACGCGGCCCACGCCGCGGCGCCCGCCTGGGGCAAGGCCGCACCCGCCGAG
CGGGCAGCGATTCTGCACAAGATCGCCGATCGGATGGAGGCGAACCTCGAAGCGCTCGCGCTGGCCGAGTCCTGGGACAA
CGGCAAGCCGATCCGCGAGACGCTCAACGCCGACATTCCGCTGGCGATCGACCACTTCCGGTACTTCGCCGGGGCCATCC
GCGCCCAGGAAGGCTCGCTGAGCCAAATCGACTCCGACACCGTGGCCTATCACTTCCATGAACCGCTGGGCGTGGTGGGC
CAGATCATCCCGTGGAACTTCCCGCTGTTGATGGCCACCTGGAAGCTGGCCCCCGCCCTGGCCGCCGGCAACGCCGTTGT
GCTCAAGCCCGCCGAGCAGACCCCGGCCTCGATCCTGTACCTGATGAGTCTGATCGGTGACCTGCTACCCGCCGGTGTGG
TCAACGTGGTCAACGGATTTGGGGTCGAGGCCGGCAAGCCGCTGGCATCGAGCAACCGAATCGCCAAGATCGCCTTCACC
GGCGAGACCACCACCGGACGGCTGATCATGCAATATGCCAGCCAGAACCTGATCCCGGTGACGCTGGAGCTGGGCGGCAA
GAGCCCCAACATCTTCTTCTCCGACGTGCTGGCCGCCCACGACGACTACCAGGACAAGGCGCTGGAGGGCTTCACCATGT
TCGCCCTCAACCAGGGCGAGGTGTGCACCTGCCCGTCCCGCGGCCTGATTCAGGCCGACATCTACGACCGGTTCCTGGAA
CTGGCGGCGATCCGCACCAAGGCCGTGCGCCAGGGGGATCCACTCGACACCGAGACCATGATCGGCGCGCAGGCCTCCAA
CGACCAGCTGCAAAAGATCTTGTCCTACATCGAGATCGGCAAAGAGGAGGGTGCGCGGGTGGTCACCGGGGGTGAGCGCT
GCGAACTGGGCGGCGACCTCAACGGCGGCTACTACGTGCAGCCCACCATCTTCGAAGGCACCAACAACATGCGCATCTTC
CAAGAGGAGATCTTCGGCCCGGTGGTCTCGGTCACCTCGTTCACCGACTACGACGACGCGATCCGCATCGCCAACGACAC
CCTCTACGGGCTGGGCGCGGGTGTGTGGAGCCGTGACGGCAACACCGCCTATCGGGCCGGGCGTGACATCAAGGCCGGCC
GCGTCTGGACGAACTGCTACCACGCCTATCCCGCCCACGCGGCGTTCGGCGGCTACAAGCAGTCCGGCATCGGACGCGAG
AACCACAAGATGATGCTCGACCACTACCAGCAGACCAAGAACCTGCTGGTGTCCTACGGCAGCAAGGCCCAGGGCTTCTT
CTGA

Protein sequence :
MTVFARPGAHSSLMTFESRYGNFIGGEWVAPAAGEYFEDLTPVTGAPFCEVPRSTDVDVEKALDAAHAAAPAWGKAAPAE
RAAILHKIADRMEANLEALALAESWDNGKPIRETLNADIPLAIDHFRYFAGAIRAQEGSLSQIDSDTVAYHFHEPLGVVG
QIIPWNFPLLMATWKLAPALAAGNAVVLKPAEQTPASILYLMSLIGDLLPAGVVNVVNGFGVEAGKPLASSNRIAKIAFT
GETTTGRLIMQYASQNLIPVTLELGGKSPNIFFSDVLAAHDDYQDKALEGFTMFALNQGEVCTCPSRGLIQADIYDRFLE
LAAIRTKAVRQGDPLDTETMIGAQASNDQLQKILSYIEIGKEEGARVVTGGERCELGGDLNGGYYVQPTIFEGTNNMRIF
QEEIFGPVVSVTSFTDYDDAIRIANDTLYGLGAGVWSRDGNTAYRAGRDIKAGRVWTNCYHAYPAHAAFGGYKQSGIGRE
NHKMMLDHYQQTKNLLVSYGSKAQGFF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-133 63
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 2e-140 61
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 2e-140 61
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 2e-140 61
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 7e-140 61
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 8e-63 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MMAR_4912 YP_001853171.1 aldehyde dehydrogenase VFG0082 Protein 7e-134 63