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Name : mbtA (MMAR_3698) Accession : YP_001851969.1 Strain : Mycobacterium marinum M Genome accession: NC_010612 Putative virulence/resistance : Virulence Product : bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase Function : - COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism COG ID : COG1021 EC number : - Position : 4555360 - 4557012 bp Length : 1653 bp Strand : + Note : involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins (initiation step of mycobactin chain growth). activates the mycobactin ACP in two half-reactions: activates salicylic acid as acyladenylate (adenylation step) + tr DNA sequence : GTGCCTGTTACATCCGCCCAGCCGCCTCGACCGGGGCCGGTGGCCGGGTTCATTCCGTACCCACCCGAACGAGTGGCCAG CTACCGCGCCGCCGGTTATTGGACCGGTCGCAGCATCGGCTCGCTGTTGCGGCAAGCGGCCGCACGCTGGCCTGACCGAG TGGGTGTGGTCGACGCCGGCGCCAGCCATACGTTCTGCGAACTGGACAAACTGGCCGATCGAGCCGCCGCGGGCTTCGTT TCGCTGGGCATCGCACCGGGCGACCGGGTGCTGCTGCAGTTACCCAATTCGTGCCGGTTCGCGGTCGCCTTGTTCGGCCT GTTGCGCGCCGGAGCCATCCCGGTGATGTGCCTGCCCGGACACCGGCTGGCAGAACTGCACCACTTCGCCGAGGTCAGCG GTGCGGTGGGTTTGATCGTCGCGCAGCACGCCGGCGGCTTCGACTACCGGTCGATGGCCGAGCGGTTGGTCGCCGCTCAC CCCCAGTTGCGCCACGTCATCATCGACGGCGAGTCCGGGCCCTTTCTGCCGTGGTCGTCGCTGTCCGAAGGCGCCACACC CGACATCGATGTCGACACCACATCGCCCGCCTTGTTACTCGTCTCAGGTGGCACCACCGGCACTCCGAAACTGATCCCCC GAACACACGACGACTACGTCTACAACGCCACCGCGAGTGCGCAGTTGTGCCGGCTGACCGCTGACGACGTGTACCTCGTG TCGCTGCCGGCGGCGCACAACTTCCCGTTGGCATGTCCGGGCATACTCGGCTCGATGGCCGTCGGCGCCACCATCGTTTT CAGCACCGACCCCAGCCCGGAGGCCGCCTTCACCTTGATCGAGCGCCACGGCGTCACCGTCACGGCGCTGGTACCCGCGC TGGCCAAACTGTGGACCCAGGCCTGTGACTGGGAGCCGGTAACCCCGAAGTCTTTGCGGCTATTGCAAGTTGGTGGCTCC AGATTGGAGCCCGAGGATGCTCGCCAGGCACGAGAGGCATTGACCCCGGGGCTGCAACAGGTCTTCGGGATGGCCGAAGG ACTGCTGAACTTCACCCGCCTCGAAGATCCGCCGGACCTCCTCGAGCACACCCAGGGCCGGCCCCTGTGCTCCGCTGACG AATTGCGCATTGTCGACGGCGCGGGCGCGCCGGTGGCTCCCGGCGCAGAGGGCGAGCTACTGGTGCGCGGTCCCTACACC ATCAACGGCTACTTCTGCGCCGACCGAGACAACGAGCGCTGCTTCGATCCAGCCGGCTTCTATCGCAGCGGCGACTTGGT CCGACTCCGCGACGACGGCTACCTGCAGGTCACCGGGCGCGTCAAAGACGTCATCTGCCGCTGCGGTGAGACCATCTCGG CCCAGGACCTCGAAGAACAGTTGCTCAGCCACCCGGCGATCCGCTCGGCCGCGGCGGTGCCACTGCCGGACCCGGATATG GGCGAGCTGATCTGCGCTGCAATTGTTTTCGCGGGGCCACCGCAGACGCCGCAGACCTTGTCGGGACTCAATGACTATCT CGAGCAGCGTGGCGTTGCCGCACATATCCGCATCGATCGGCTGGTCGCGATGCCGTCGCTGCCGACCACACCGGTGGGAA AGATCGACAAGAAGGCGATCGCGAGCCAGATCCTGACAACCACGGCGACCTGA Protein sequence : MPVTSAQPPRPGPVAGFIPYPPERVASYRAAGYWTGRSIGSLLRQAAARWPDRVGVVDAGASHTFCELDKLADRAAAGFV SLGIAPGDRVLLQLPNSCRFAVALFGLLRAGAIPVMCLPGHRLAELHHFAEVSGAVGLIVAQHAGGFDYRSMAERLVAAH PQLRHVIIDGESGPFLPWSSLSEGATPDIDVDTTSPALLLVSGGTTGTPKLIPRTHDDYVYNATASAQLCRLTADDVYLV SLPAAHNFPLACPGILGSMAVGATIVFSTDPSPEAAFTLIERHGVTVTALVPALAKLWTQACDWEPVTPKSLRLLQVGGS RLEPEDARQAREALTPGLQQVFGMAEGLLNFTRLEDPPDLLEHTQGRPLCSADELRIVDGAGAPVAPGAEGELLVRGPYT INGYFCADRDNERCFDPAGFYRSGDLVRLRDDGYLQVTGRVKDVICRCGETISAQDLEEQLLSHPAIRSAAAVPLPDPDM GELICAAIVFAGPPQTPQTLSGLNDYLEQRGVAAHIRIDRLVAMPSLPTTPVGKIDKKAIASQILTTTAT |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ybtE | NP_669710.1 | salicyl-AMP ligase | Virulence | HPI | Protein | 4e-94 | 46 |
| ybtE | NP_993003.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 4e-94 | 46 |
| ybtE | YP_070120.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 4e-94 | 46 |
| ybtE | CAA21394.1 | - | Virulence | HPI | Protein | 4e-94 | 46 |
| irp5 | YP_001006819.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 1e-94 | 46 |
| ybtE | AAA93464.1 | yersiniabactin 2,3-dihydoxybenzoate-AMP ligase | Virulence | HPI | Protein | 3e-94 | 46 |
| irp5 | CAA73130.1 | Irp5 protein | Virulence | HPI | Protein | 7e-95 | 46 |
| ybtE | YP_853079.1 | yersiniabactin siderophore biosynthetic protein | Virulence | PAI IV APEC-O1 | Protein | 5e-94 | 46 |
| irp5 | YP_002346898.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 4e-94 | 46 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| mbtA | YP_001851969.1 | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | VFG1817 | Protein | 0.0 | 72 |
| mbtA | YP_001851969.1 | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | VFG0168 | Protein | 9e-88 | 43 |
