Gene Information

Name : lysS (MMAR_2447)
Accession : YP_001850752.1
Strain : Mycobacterium marinum M
Genome accession: NC_010612
Putative virulence/resistance : Unknown
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : -
Position : 2955106 - 2958399 bp
Length : 3294 bp
Strand : -
Note : catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA

DNA sequence :
GTGCAGGGTAGGCACATCTCTCGGTATGACTGGGTTCCGGCCGCCGCTGGCTGGGCCGTCGGGGTCATCGCGACCCTGTC
ACTGCTGGCCAGCATTTCGCCGCTGGTTCGGTGGATCATCAAGGTTCCCCGAGAATTCATCAACAGTTATCTGTTCAATT
TTCCCGACACCAGCTTCGCCTGGTCTTTTGTGCTGGCACTGCTGGCGGCGGCCCTGGCCGCGCGTAAACGGATCGCCTGG
CTACTGCTGCTGACCAACGTCGTCTTGGCGGCTTTCCTCAACGCCGCCGACATCGCCGCGGGCGGCAACACCGCGGCCCA
GAACTTCGGCGAAAACCTCGGGTTCGCAGTACACGTGGTGGCGATCGTCGTGCTGGTGCTGGGATATCGGCAGTTCTGGG
CCAAGGTCCGCAGGGGTGCACTGTTCAAGGCGGCCGCGGTGCTGGTGGCCGGTGGTGCGATCGGAATCCTGGTGTCCTGG
GGCCTGGTCGAGCTGTTTCCGGGATCCCTCGCGCCGCACGACCGTTTGCCCTACGTGGCCAACCGGGTGATCGGCTTCGC
CCTGGCCGATCCCGACCTGTTCACCGGCCGGCCGCACGTCTTCCTCAACGCCATGTTCGGCTTGTTCGGCGCTCTCGCCC
TAATTGCGGCCACCATCGTGCTGTTTCAGTCCCAGCGTGCCGATAACGCGTTGACCGGCGAGGACGAGTCGGCCATCCGG
GGGTTGCTCGAGCTGTACGGCAACAGCGACTCGCTGGGCTACTTCGCGACCCGTCGCGACAAGTCGGTGATATTCGCCTC
CAGCGGCCGTGCCGCCATCACCTATCGGGTCGAAATCGGTGTCTGCCTGGCCAGTGGCGATCCGGTAGGCGACCCGCGGT
CGTGGCCGCAAGCGATCGACGCATGGCTACGGCTGTGCCAGACCTATGGTTGGTCGCCCGGTGTGATGGGGGCCAGTTCA
CAAGGGGCCAAGGCATATCGCGAGGCGGGTCTGAACGCGCTTGAACTCGGCGACGAGGCGATCTTGGTGCCCGCCGATTT
CACGCTGTCCGGCCCCGACATGCGCGGCGTGCGCCAAGCCGTGACCAGGGCACGTCGCGCCGGTCTGACGGTGCGCATCC
GGCGTCACCGGGATATCTCCGACGCCGAAATGGAACAGACGATCGATCGCGCCGACGGCTGGCGCGACACCGAATCCGAG
CGCGGCTTCTCGATGGCGCTGGGCCGCCTCGGCGACCCGGCCGACACCGACTGCTTGTTGGTCGAGGCGCTTGACCCCGA
CGACCTGGTAGTGGCGATGTTGTCGCTGGTGCCTTGGGGTACCAGCGGGGTCTCCCTGGACCTGATGAGACGTTCTCCGC
AATCGCCCAACGGCACCATCGAGCTGATGGTCAGCGAACTGGCGCTGCGCGCCGAAGGCCTCGGCATCAGCCGCATCTCG
CTGAACTTCGCGATGTTCCGGTCGGCTTTCGAGCAAGGCGCCCAATTGGGCGCCGGGCCGGTGGCCCGCTTGTGGCGTTG
GCTGCTGGTGTTCTTTTCCCGGTGGTGGCAGATCGAGACGCTGTACCGATCCAACCAGAAGTATCAGCCGCAATGGGTGC
CCCGCTACGCCTGCTATGAGGACGCGCGGGTGATCCCCAAGGTGGGTGTCGCCTCCGTGATCGCCGAGGGGTTCCTGGTA
TTGCCATTCAGCCGGCGCAACAAGGTGCACACCGGTCACCATCCCGCGGTCCCCGAACGGCTGGCGGCCACCGGTTTGTT
GCACCATGACGGATCGGCGCCCGACGTCAGCGGGCTGCGGCAATCGGCAATTGCCGACGGCGACGACCCCCAACGTCGGC
TGCCCGAGCAAGTCCGGGTGCGGCTGAACAAGTTGAAGAAATTGCGCAGCAGCGGCATTGACGCCTATCCGGTGGGCGAA
CCGCCCACTCATACAGTCGCGCAAGCGATGGATGCCGACGACCAGGCGAGCGTGTCGGTATCCGGGCGGATCTTGCGGGT
ACGCAACTACGGTGGAGTGCTGTTCGCGCACTTGCGCGACTGGAGCGGCGAGATTCAGGTGCTGCTGGACAACTCGCGAC
TCGAGCAGGGCCGCGCCGCGGATTTCAACGCGGCCATAGACCTTGGTGACCTGGTCGAGATGACCGGGCAGATGGGTTCG
AGCAAGACCGGAACGCGATCACTGATCGTGCGCCGCTGGCGTCTGATCGGTAAGTGCCTGCGCCCCTTGCCCAACAAGTG
GAAGGGGTTGACCGATCCCGAAGCCCGAGTGCGGACCCGCTACGTAGACCTCGCTGTCAACGCCGAGTCGCGCGCCCTCA
TCACGGCCCGCAGCGCGGTGCTGCGCTCCGTCCGAGAAACCCTGTCCGCCAAGGGGTTCATCGAGGTCGAGACACCCATC
CTGCAACAGGTACACGGCGGCGCAACGGCCCGCCCGTTCATCACCCACATCAACACCTACTCCATGGACCTGTTCTTGCG
CATCGCGCCGGAGCTGTATCTCAAGCGGCTGTGCGTCGGCGGGGTGGAACGGGTCTTCGAACTCGGCCGGGCCTTTCGGA
ATGAGGGCGTCGACTTCAGCCACAACCCGGAGTTCACCCTGTTGGAGGCCTATCAAGCGCACGCCGACTACCGGGTATGG
ATCGACAGCTGCCGCGAGCTGATCCAAAACGCCGCCCAGGCCGCCAACGGTGCACCCGTCGCGATGCGCCCGGCCGGCGG
CGGCCGCCTCGAACCGGTGGACATCTCGGGGGTCTGGGCGGTCAAGACCGTGCACGACGCGGTGTCAGAGGCCCTCGGTG
AGCAGATCGACGCCGATACCGACTTGGCCACCCTGCGCAGGCTGGCCGACGCCGCACGCATCCCCTATCGGGCGCAGTGG
GATGCCGGCGCGGTGGTGCTGGAGCTCTACGAACACCTGGTGGAGAGCCGCACCGAGCAGCCGACGTTCTACCTCGACTT
CCCGACCTCGGTGTCCCCGCTGACCCGGCCGCATCGCAGCAAGCCCGGAATCGCCGAACGTTGGGACCTGGTGGCCTGGG
GCGTCGAGCTTGGTACCGCCTACAGCGAGCTCACCGACCCCGTCGAACAGCGGCTCCGCTTGGAGGAGCAGTCTTTGCTC
GCCGCCGGCGGGGATCCCGAAGCGATGCAGCTCGACGAAGACTTCCTGCAGGCCATGGAATACGCGATGCCGCCCACCGG
GGGCCTCGGCATGGGCGTCGACCGGGTCGTCATGCTGATCACCGGGCGCAGCATCCGTGAAACGCTCCCGTTCCCGCTGG
CCAAGCCGCACTAA

Protein sequence :
MQGRHISRYDWVPAAAGWAVGVIATLSLLASISPLVRWIIKVPREFINSYLFNFPDTSFAWSFVLALLAAALAARKRIAW
LLLLTNVVLAAFLNAADIAAGGNTAAQNFGENLGFAVHVVAIVVLVLGYRQFWAKVRRGALFKAAAVLVAGGAIGILVSW
GLVELFPGSLAPHDRLPYVANRVIGFALADPDLFTGRPHVFLNAMFGLFGALALIAATIVLFQSQRADNALTGEDESAIR
GLLELYGNSDSLGYFATRRDKSVIFASSGRAAITYRVEIGVCLASGDPVGDPRSWPQAIDAWLRLCQTYGWSPGVMGASS
QGAKAYREAGLNALELGDEAILVPADFTLSGPDMRGVRQAVTRARRAGLTVRIRRHRDISDAEMEQTIDRADGWRDTESE
RGFSMALGRLGDPADTDCLLVEALDPDDLVVAMLSLVPWGTSGVSLDLMRRSPQSPNGTIELMVSELALRAEGLGISRIS
LNFAMFRSAFEQGAQLGAGPVARLWRWLLVFFSRWWQIETLYRSNQKYQPQWVPRYACYEDARVIPKVGVASVIAEGFLV
LPFSRRNKVHTGHHPAVPERLAATGLLHHDGSAPDVSGLRQSAIADGDDPQRRLPEQVRVRLNKLKKLRSSGIDAYPVGE
PPTHTVAQAMDADDQASVSVSGRILRVRNYGGVLFAHLRDWSGEIQVLLDNSRLEQGRAADFNAAIDLGDLVEMTGQMGS
SKTGTRSLIVRRWRLIGKCLRPLPNKWKGLTDPEARVRTRYVDLAVNAESRALITARSAVLRSVRETLSAKGFIEVETPI
LQQVHGGATARPFITHINTYSMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYRVW
IDSCRELIQNAAQAANGAPVAMRPAGGGRLEPVDISGVWAVKTVHDAVSEALGEQIDADTDLATLRRLADAARIPYRAQW
DAGAVVLELYEHLVESRTEQPTFYLDFPTSVSPLTRPHRSKPGIAERWDLVAWGVELGTAYSELTDPVEQRLRLEEQSLL
AAGGDPEAMQLDEDFLQAMEYAMPPTGGLGMGVDRVVMLITGRSIRETLPFPLAKPH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lysS1 YP_005686365.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 8e-154 44
lysS1 YP_005682181.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 2e-153 44
lysS1 YP_005684273.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 8e-154 44
lysX YP_003784331.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 8e-154 44