Gene Information

Name : guaA (MMAR_1148)
Accession : YP_001849461.1
Strain : Mycobacterium marinum M
Genome accession: NC_010612
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1378111 - 1379688 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGCAGAACCCGTTGACCTCGATGTGGCTGGACCGGTGGGCCGGCCGGTGTTGGTGGTGGATTTCGGTGCGCAGTATGC
GCAATTGATCGCCCGCCGGGTCCGGGAAGCGCGGGTGTTCTCGGAGGTGATCCCGCACACCACCTCGATCGAGGAGATCA
AGGCCCGTGACCCGCTGGCGCTGGTGCTTTCCGGGGGGCCGGCCAGCGTGTATGCGCCGGGCGCTCCGCAGCTTGATCCG
GCGCTGTTCGACCTGGGTCTGCCAGTGTTCGGTATTTGCTATGGCTTCCAGGTGATGGCACAGGCGCTCGGCGGAACGGT
CGCTCATACCGGGACCAGCGAGTACGGCCGGACGGAGCTGAAAGTCCTTGGCGGCGACTTGCATTCAGACTTGCCCGACA
TCCAGCCGGTCTGGATGAGCCACGGTGACGCGGTCACCGCGGCCCCGGACGGATTCGAGGTGGTGGCCAGCAGTGCCGGT
GCCGCGGTGGCCGCCTTCGAGAACCGGGAGCGACGCCTGGCCGGGGTGCAATATCACCCGGAGGTGATGCACACCCCGCA
CGGGCAACAGATCCTCGGCCGGTTTCTGCATGACTTCGCCGGGATCGGCGCCCGGTGGACCCCCGCCAATATCGCCAATG
CGCTGATCGAGCAGGTACGCACGCAGATCGGCGATGGCCACGCCATCTGCGGACTGTCCGGTGGGGTGGATTCCGCGGTG
GCCGCGGCGCTGGTGCAACGCGCCATCGGTGACCGGTTGACCTGTGTCTTCGTCGATCACGGGTTGTTGCGTGCCGGCGA
GCGTGCGCAGGTGGAGCGCGACTTCGTGGCCGCGACCAAGGCCAATCTGGTCACCGTCGACGTGGCCGACACCTTCCTGG
CGGCCTTGTCGGGTGTGACCGACCCCGAGGGCAAGCGCAAGATCATCGGTCGCCAGTTCATCCGGGCGTTCGAGGGCGCG
GTGCGCGATGTGCTGGATGGCCGCGACATCGAGTTTCTGGTGCAGGGCACGCTGTATCCGGACGTGGTGGAATCCGGCGG
AGGCAGCGGCACCGCCAACATCAAGAGCCACCACAATGTCGGCGGTCTGCCCGACGATCTGAAGTTCGCCCTGGTCGAGC
CGTTGCGGCTGCTGTTCAAGGACGAGGTGCGCGCGGTCGGGCGGGAGTTGGGTCTGCCGGAGGAGATCGTTGCGCGCCAA
CCTTTTCCGGGGCCGGGCCTGGGCATCCGGATCGTCGGGGAGGTCACCGGGCAGCGGCTGGACACGCTGCGTCGCGCCGA
CTCGATCGCACGCGAGGAGTTGACCGCGGCGGGCCTGGACAACCAGATCTGGCAGTGTCCGGTGGTGCTGCTGGCCGATG
TCCGCTCGGTCGGAGTGCAGGGCGACAACCGCACCTACGGGCATCCGATCGTGCTGCGGCCGGTGTCCAGCGAGGACGCC
ATGACCGCTGACTGGACCCGGGTGCCCTTCGAGGTGCTCGAGCGCATCTCGACCCGCATCACCAACGAGGTGCCCGAGGT
CAACCGCGTGGTGCTGGATGTCACCAGCAAGCCGCCGGGCACCATCGAGTGGGAATAA

Protein sequence :
MAEPVDLDVAGPVGRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTTSIEEIKARDPLALVLSGGPASVYAPGAPQLDP
ALFDLGLPVFGICYGFQVMAQALGGTVAHTGTSEYGRTELKVLGGDLHSDLPDIQPVWMSHGDAVTAAPDGFEVVASSAG
AAVAAFENRERRLAGVQYHPEVMHTPHGQQILGRFLHDFAGIGARWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAV
AAALVQRAIGDRLTCVFVDHGLLRAGERAQVERDFVAATKANLVTVDVADTFLAALSGVTDPEGKRKIIGRQFIRAFEGA
VRDVLDGRDIEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFALVEPLRLLFKDEVRAVGRELGLPEEIVARQ
PFPGPGLGIRIVGEVTGQRLDTLRRADSIAREELTAAGLDNQIWQCPVVLLADVRSVGVQGDNRTYGHPIVLRPVSSEDA
MTADWTRVPFEVLERISTRITNEVPEVNRVVLDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 77
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 6e-129 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-129 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-129 51