Gene Information

Name : thyA (LAF_0887)
Accession : YP_001843703.1
Strain : Lactobacillus fermentum IFO 3956
Genome accession: NC_010610
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : -
Position : 1038989 - 1039948 bp
Length : 960 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGACGGTAAATCATAATGAAGAACAGTACCTAGACCTGGCGCGCCACGTCCTGGAATTCGGTGACCAAAAGGGGGACCG
GACCGGAACCGGAACTAAGTCGGTCTTCGGCTACCAGATGCGCTTTAACCTGCAGGAAGGTTTCCCGATCCTGACGACCA
AGAAGGTGGCCTTTGGGCTGGTCAAAAGCGAGCTCCTCTGGTTCTTACGCGGCGACACCAACATCCGCTTTCTCTTGGAA
CACAAAAACCACATCTGGGACGAGTGGGCCTTTAAGAAGTGGGTCGAAAGCGACGAGTATACGGGCCCGGACATGACCGA
CTTTGGCCGCCGTTCCTTGGTGGATGCCGCATTTAACGAAGAGTACAAAAAGGAAAAGCGGGCCTTTTGCCAGCGGATCT
TAGAGGATGACGACTTTGCTAAGCAGTACGGCAACCTAGGTTTGGTGTACGGCTCCCAGTGGCGGAGTTGGCAAACGCCA
AACGGCCCGGTTGACCAAATCAAAAAGGTGATCGAGCAGATTAAGACCAATCCCGATTCTCGGCGGTTGATCGTAACGGC
TTGGAACCCGGCCGACGTCGATAACATGGCCCTGCCACCGTGCCACACCATGTTCCAGTTTTACGTGAACAACGGCAAGC
TGTCTTGCCAGCTTTACCAGCGCAGTGCCGACATCTTCTTAGGGGTACCGTTTAACATCGCCTCTTACGCCTTACTGACC
CACATGATTGCGCACCAGTGCGGGCTGGAAGTTGGGGAATTTGTCCACACCTTGGGGGACGCTCACATCTACTTAAACCA
CCTCGATCAGATTAAAGAACAGCTCAGCCGCCCAGTTCACCAGGCACCGCAGCTGATCTTGCCGGCGGAGGCCAAGCCAA
TTGACGAGTACCAAATGGAAGACATCAAGCTGGAGGGCTACGAACACGAAGACGCCATTAAGGCCCCGGTAGCGGTCTAA

Protein sequence :
MTVNHNEEQYLDLARHVLEFGDQKGDRTGTGTKSVFGYQMRFNLQEGFPILTTKKVAFGLVKSELLWFLRGDTNIRFLLE
HKNHIWDEWAFKKWVESDEYTGPDMTDFGRRSLVDAAFNEEYKKEKRAFCQRILEDDDFAKQYGNLGLVYGSQWRSWQTP
NGPVDQIKKVIEQIKTNPDSRRLIVTAWNPADVDNMALPPCHTMFQFYVNNGKLSCQLYQRSADIFLGVPFNIASYALLT
HMIAHQCGLEVGEFVHTLGDAHIYLNHLDQIKEQLSRPVHQAPQLILPAEAKPIDEYQMEDIKLEGYEHEDAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 1e-98 64