Gene Information

Name : tpx (LEPBI_I2904)
Accession : YP_001840249.1
Strain :
Genome accession: NC_010602
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 2998555 - 2999070 bp
Length : 516 bp
Strand : +
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGGCACAAGTAACACTCAAAGGAAATCCCGTTCCTCTAGAAGGATCCATCCCAAAACCTGGAGACAAAGCTCCTGATTT
TAAAGTCGCCAAACAAGATTTAAGTGATATTACGTTAAAAGATTTAGCAGGAAAGGTTAAAATCCTTGTTGCGGTTCCGA
GTCTTGACACTCCAGTCTGTGCCATTGAAACTAAAAAATTCAACGAAAAAGTCGCAAAGGAAAATGGAATCACAACACTC
ATCATTTCAGGTGATTTACCATTTGCGATGAAACGATTTTGTACGACGGAAGGGATCAATTCCGATAACCTGATCACAGG
TTCACAGTTTAAGGACTTTTCCTTTTCCAAAAACTATGGAACTCATATTTCTAGTGGGCCACTCGCAGGTCTATCGGCAA
GAGCAGTGTTTGTAGTGGACAAAGACGATGTTGTACGATACACGGAGCTTGTTCCTGAAATTGGAAGTGAGCCAAACTAC
GATACCGTACTTGCCGAAGCTAAGAAACTTGTTTAG

Protein sequence : 
MAQVTLKGNPVPLEGSIPKPGDKAPDFKVAKQDLSDITLKDLAGKVKILVAVPSLDTPVCAIETKKFNEKVAKENGITTL
IISGDLPFAMKRFCTTEGINSDNLITGSQFKDFSFSKNYGTHISSGPLAGLSARAVFVVDKDDVVRYTELVPEIGSEPNY
DTVLAEAKKLV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 4e-27 41
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 2e-27 41
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 3e-27 41
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 1e-27 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001840249.1 thiol peroxidase VFG0087 Protein 6e-28 41