Gene Information

Name : SPCG_0171 (SPCG_0171)
Accession : YP_001834888.1
Strain : Streptococcus pneumoniae CGSP14
Genome accession: NC_010582
Putative virulence/resistance : Resistance
Product : tetracycline resistance protein TetM
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0480
EC number : -
Position : 171705 - 173639 bp
Length : 1935 bp
Strand : +
Note : -

DNA sequence : 
ATGGAGGAAAATCACATGAAAATTATTAATATTGGAGTTTTAGCTCATGTTGATGCAGGAAAAACTACCTTAACAGAAAG
CTTATTATATAACAGTGGAGCGATTACAGAATTAGGAAGCGTGGACAAAGGTACAACGAGGACGGATAATACGCTTTTAG
AACGTCAGAGAGGAATTACAATTCAGACAGGAATAACCTCTTTTCAGTGGGAAAATACGAAGGTGAACATCATAGACACG
CCAGGACATATGGATTTCTTAGCAGAAGTATATCGTTCATTATCAGTTTTAGATGGGGCAATTCTACTGATTTCTGCAAA
AGATGGCGTACAAGCACAAACTCGTATATTATTTCATGCACTTAGGAAAATGGGGATTCCCACAATCTTTTTTATCAATA
AGATTGACCAAAATGGAATTGATTTATCAACGGTTTATCAGGATATTAAAGAGAAACTTTCTGCCGAAATTGTAATCAAA
CAGAAGGTAGAACTGTATCCTAATATGTGTGTGACGAACTTTACCGAATCTGAACAATGGGATACGGTAATAGAGGGAAA
CGATGACCTTTTAGAGAAATATATGTCCGGTAAATCATTAGAAGCATTGGAACTCGAACAAGAGGAAAGCATAAGATTTC
AGAATTGTTCTCTGTTCCCTCTTTATCATGGAAGTGCAAAAAGTAATATAGGGATTGATAACCTTATAGAAGTTATTACT
AATAAATTTTATTCATCAACACATCGAGGTCCGTCTGAACTTTGCGGAAAAGTTTTCAAAATTGAGTATTCGGAAAAAAG
ACAGCGTCTTGCATATATACGTCTTTATAGTGGCGTACTGCATTTGCGAGATTCGGTTAGAATATCGGAAAAGGAAAAAA
TAAAAATTACAGAAATGTATACTTCAATAAATGGTGAATTATGTAAAATTGATAAGGCTTATTCCGGGGAAATTGTTATT
TTGCAGAATGAGTTTTTGAAGTTAAATAGTGTTCTTGGAGATACAAAGCTATTGCCACAGAGAGAGAGAATTGAAAATCC
CCTCCCTCTGCTGCAAACGACTGTTGAACCGAGCAAACCTCAACAAAGGGAAATGTTACTTGATGCACTTTTAGAAATCT
CCGACAGTGACCCGCTTCTGCGATATTATGTGGATTCTGCGACACATGAAATCATACTTTCTTTCTTAGGGAAAGTACAA
ATGGAAGTGACTTGTGCTCTGCTGCAAGAAAAGTATCATGTGGAGATAGAAATAAAAGAGCCTACAGTCATTTATATGGA
AAGACCGTTAAAAAAAGCAGAGTATACCATTCACATCGAAGTTCCACCGAATCCTTTCTGGGCTTCCATTGGTCTATCTG
TAGCACAGCTTCCGTTGGGAAGTGGAATGCAGTATGAGAGCTCGGTTTCTCTTGGATACTTAAATCAATCATTTCAAAAT
GCAGTTATGGAAGGGATACGCTATGGCTGTGAACAAGGATTGTATGGTTGGAATGTGACGGACTGTAAAATCTGTTTTAA
GTATGGCTTATACTATAGCCCTGTTAGTACCCCAGCAGATTTTCGGATGCTTGCTCCTATTGTATTGGAACAAGTCTTAA
AAAAAGCTGGAACAGAATTGTTAGAGCCATATCTTAGTTTTAAAATTTATGCGCCACAGGAATATCTTTCACGAGCATAC
ACCGATGCTCCTAAATATTGTGCGAACATCGTAGACACTCAATTGAAAAATAATGAGGTCATTCTTAGTGGAGAAATCCC
TGCTCGGTGTATTCAAGAATATCGTAGTGATTTAACTTTCTTTACAAATGGACGTAGTGTTTGTTTAACAGAGTTAAAAG
GGTACCATGTTACTACCGGTGAACCTGTTTGCCAGCCCCGTCGTCCAAATAGTCGGATAGATAAAGTACGATATATGTTC
AATAAAATAACTTAG

Protein sequence : 
MEENHMKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQWENTKVNIIDT
PGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIK
QKVELYPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELEQEESIRFQNCSLFPLYHGSAKSNIGIDNLIEVIT
NKFYSSTHRGPSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVI
LQNEFLKLNSVLGDTKLLPQRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLGKVQ
MEVTCALLQEKYHVEIEIKEPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVAQLPLGSGMQYESSVSLGYLNQSFQN
AVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAY
TDAPKYCANIVDTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRPNSRIDKVRYMF
NKIT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SSU05_0922 YP_001198287.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 96
SSU98_0928 YP_001200485.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 96
tetO AFJ97266.1 truncated tetracycline resistant protein Not tested Not named Protein 2e-163 75
tet(W) YP_005160006.1 tetracycline resistance protein Not tested Not named Protein 0.0 69

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM M85225.gene.p01 Protein 0.0 98
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM X04388.gene.p01 Protein 0.0 97
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM NC_009782.5559075.p0 Protein 0.0 95
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM NC_002758.1120355.p0 Protein 0.0 95
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM AM180355.1.gene636.p Protein 0.0 93
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM L09756.gene.p01 Protein 0.0 79
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM AJ295238.gene.p01 Protein 0.0 72
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM AJ222769.gene.p01 Protein 0.0 69
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM DQ294299.gene.p01 Protein 0.0 69
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM AY485126.gene.p01 Protein 0.0 69
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM FN594949.1.gene24.p0 Protein 0.0 67
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM L42544.gene.p01 Protein 9e-126 44
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM AJ514254.gene.p01 Protein 6e-121 43
SPCG_0171 YP_001834888.1 tetracycline resistance protein TetM Z21523.gene.p01 Protein 2e-109 41