|
Name : ureC (SGR_846) Accession : YP_001822358.1 Strain : Streptomyces griseus NBRC 13350 Genome accession: NC_010572 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 999079 - 1000803 bp Length : 1725 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGCCCATCCTGCCCCGCAAGCAGTACACGGACATGTTCGGCCCGACCGTCGGCGACCGCTTCCACCTCGCCGACACCAA CCTCGTCGTCGAGGTCGAGAAGGACTACAGCGAGGGGCTGTACGGCGACGAGGTCGTCTACGGCGGCGGCAAGACCATGC GGGACGGCATGGCCTCCGACCCGCAGGCCACCTCCGCCCAGGGGGCCCTGGACACCGTCATCACCAACGTGGTGGTCATC GACCCGGTGGTGGGTGTCGTCAAGTGCGACATCGGCATCAAGGACGGCTTCATCGTCGGCATCGGCAAGTCGGGCAACCC GCAGACACAGAACAACGTCGACCCGGACCTGGTCATCGGACCCGGTACGGAGGCCATCGCGGGGGAGCACCTGATCGCCA CCGCCGGGGCCATCGACACCCACGTCCATCTGATCGCCCCGCAACAGGCCGAGCAGGCGCTGAGCAACGGCATCACCACC CTCATCGGCGGTGGCACCGGTCCGACCGACGGCTCCAACGGCACGACCTGCACTCCCGGCCCGTACAACATCGCCCGGCT GCTCCAGTCCGCCGAGACCCTTCCGGTCAACCTCGGCATCATGGCCAAGGGCAACGGCAGTCTGCCGGAGGCGATCAAGG AGCAGGTCGTCGCCGGCGCCTGCGCGCTCAAGGTGCACGAGGACTGGGGCGCCACCCCGGCCGTGATCGACAACGCGCTG AGCGTCGCGGACGAGCACGACGTCCAGGTGGCCATCCACACCGACAGCCTGAACGAAGGCGGCTTCTTCGAGGACACCCG CTCCGCGATCGACGGCCGGGCCATCCACACGTTCCACAGCGAGGGCGCGGGCGGCGGTCACGCCCCCGACATCCTGCGGA TCGCCGGTGAACCGAACGTCCTGCCGTCCTCCACCAACCCGACGCTGCCGTACACCAAGAACTCGGTGGACGAGCTGCTC GACATGGTCATGGTCTGCCACCACCTCAGCCACGACATCCCCGAGGACGTCTCCTTCGCCGACAGCCGGGTCCGGGCCGA GACGATCGCCGCCGAGTCGGTGCTCCACGACCTCGGCGTCATCAGCATGTTCTCCTCGGACTCCCAGGCCATGGGGCGGA TCGGGGAGTCCGTCACCCGGGCCTTCCAGACCGCACACCACTGCAAGGACAAGCTCGGCGTGCTGGAGGGCGACTCGGCG CGCAACGACAACCAGCGCGTGCTGCGCTACCTGGCCAAGGTCACCATCAACCCGGCCATCGCCTCGGGGATCTCCGACTA CGTGGGCTCGATCGAGAAGGGCAAGCTCGCCGACATCGTGCTGTGGCCCATCCACTCCTTCGCCGCGAAGCCCAAGATGA TCATCAAGGGCGGCATCGTCTCCTGGGCGCAGATGGGCGACCCCAACGCCTCGCTGCCGACCCCGCAGCCCGTCATCTAC CGGCCGATGTTCGGCCAGTACGGCAAGGCCCTGCAAGCGACCCACGCGACCTTCATGTCCCAGGCGGGCATCGCCGCCGG GGTCCCGGCCGAGCTCGGCCTGAACCGCAAGGTCCTGCCCGTGCGCCGTACGCGCACCATCGGCAAGCACAACATGATCC GCAACGACGCCCTCCCCGACATCAAGGTCGACCCGGAGACGTTCAAGGTCACGCTGAACGGCCGGGTCGCCACCATCGAC CCGGCCGAGACGCTGCCCCTCAACCACCTCTACTTCCTGGTCTAG Protein sequence : MPILPRKQYTDMFGPTVGDRFHLADTNLVVEVEKDYSEGLYGDEVVYGGGKTMRDGMASDPQATSAQGALDTVITNVVVI DPVVGVVKCDIGIKDGFIVGIGKSGNPQTQNNVDPDLVIGPGTEAIAGEHLIATAGAIDTHVHLIAPQQAEQALSNGITT LIGGGTGPTDGSNGTTCTPGPYNIARLLQSAETLPVNLGIMAKGNGSLPEAIKEQVVAGACALKVHEDWGATPAVIDNAL SVADEHDVQVAIHTDSLNEGGFFEDTRSAIDGRAIHTFHSEGAGGGHAPDILRIAGEPNVLPSSTNPTLPYTKNSVDELL DMVMVCHHLSHDIPEDVSFADSRVRAETIAAESVLHDLGVISMFSSDSQAMGRIGESVTRAFQTAHHCKDKLGVLEGDSA RNDNQRVLRYLAKVTINPAIASGISDYVGSIEKGKLADIVLWPIHSFAAKPKMIIKGGIVSWAQMGDPNASLPTPQPVIY RPMFGQYGKALQATHATFMSQAGIAAGVPAELGLNRKVLPVRRTRTIGKHNMIRNDALPDIKVDPETFKVTLNGRVATID PAETLPLNHLYFLV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 2e-136 | 58 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 2e-136 | 58 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 5e-135 | 55 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-135 | 55 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-135 | 55 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 6e-135 | 55 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_001822358.1 | urease subunit alpha | VFG0270 | Protein | 1e-134 | 55 |
