Gene Information

Name : smpB (SGR_4561)
Accession : YP_001826073.1
Strain : Streptomyces griseus NBRC 13350
Genome accession: NC_010572
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 5359164 - 5359652 bp
Length : 489 bp
Strand : +
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGGCCAAGGAAAAAGACACCGGGCGCAAGATGATCGCGCAGAACAAGAAGGCGCGGCACGACTACACGATCCTCGACAC
CTACGAGTGCGGCCTCGTGCTCATGGGCACGGAGGTCAAGTCCCTGCGCATGGGGCGGGCCTCCCTGGTCGACGGCTTCG
TCCAGATCGACGACCACGAGGCATGGCTCCACAACATCCACGTACCCGAGTACGTCCAGGGCACCTGGACCAACCACGCG
GCCAAGCGGAAGCGGAAGCTGCTGCTGCACCGGGCCGAGATCGACAAGCTGGAGTCGAAGTCGCAGGAGACGGGCCACAC
GATCGTGCCGCTCGCGCTGTACTTCAAGGACGGCCGGGTCAAGGTCGAGATCGCGCTCGCGAAGGGCAAGAAGGAGTACG
ACAAGCGGCAGACGCTCCGCGAGAAGCAGGACACGCGGGAGACGAACCGCGCCATCGCGGCGGCCCGCCGGCGGCAGCGC
AGCGCCTGA

Protein sequence :
MAKEKDTGRKMIAQNKKARHDYTILDTYECGLVLMGTEVKSLRMGRASLVDGFVQIDDHEAWLHNIHVPEYVQGTWTNHA
AKRKRKLLLHRAEIDKLESKSQETGHTIVPLALYFKDGRVKVEIALAKGKKEYDKRQTLREKQDTRETNRAIAAARRRQR
SA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 2e-40 58
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 5e-31 51
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 2e-19 41