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Name : ureC (SGR_236) Accession : YP_001821748.1 Strain : Streptomyces griseus NBRC 13350 Genome accession: NC_010572 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 252842 - 254545 bp Length : 1704 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGGCCCAGCTGACCCGCGCCGCCTACGCGTCGCTCTACGGCCCCACCACCGGGGACCGGATCCGCCTCGCCGACACCGA CCTCTGGATCGAGGTGGAGGAGGACCGGTGCTTCGGCGGCGACGAAGCCGTCTTCGGAGGCGGCAAGTCCATTCGCGAGT CGATGGCCCAGGCCACCGCGTCCCGCGCCGAGGGCGCCCCCGACCTGGTCATCACCAACGCCGTCGTCCTGGACCACTGG GGCGTCGTCAAGACCGACGTCGGTGTCCGCGACGGGCGGATCGTCGCCCTCGGCCGCTCCGGCAACCCCGACATCAGCGA CGGCGTGCACCCGGACCTGGTGATCGGCCCGGGCACCGACGTGATCTCCGGCGAGGGGCGCATCCTCACCGCCGGAGCCG TCGACACCCACGTCCACTTCCTGATGCCGGAGACCCTCCACGAGGCGCTCGCCACCGGCACCACCACCGTCATCGGGGGC GGCACCGGCGCCACCGAGGGCTCCAAGGCCACCACCGTCACCCCCGGCGCCTGGAACCTCGCCATGATGCACCGGTCCCT GGACCGCGTCCCGCTCAACGTCATGCTGTTCGGCAAGGGTTCCACCGTCGGCGAGGAAGCCCTGCGCGAGGCGGCCCTCA GCGGCGCCGGCGGCTACAAGGTCCACGAGGACTGGGGCGCCACCCCGGCCGCGATCGACGCCGCGCTGCGGGCGGCCGAC GCCTACGGCCTCCAGGTGGCGCTGCACGCGGACAGCCTCAACGAGGTCGGCTACGTCGAGGGCACCCTGGACGCCATCGC CGGACGCGGCATCCACGTCTTCCACGCCGAGGGCGCGGGCGGCGGCCACGCTCCCGACATCATCACCGTGGCCTCACACC CCAACATCCTCCCCGCGTCCACCAACCCGACGCTCCCGCACACCGTCAACACCGTCGCCGAGCACCTCGACATGCTGATG GTGTGCCACCACCTCAACCCCCGGGTCCCCGAGGACCTCGCGTTCGCCGAGTCCCGGATCCGGGCCACCACCATCGCCGC CGAGGACGTGCTGCACGACATCGGCGCACTCTCCATCACCTCCTCCGACGCCCAGGCGATGGGCCGCATCGGCGAGGTCG TCTGCCGCACCTGGCAGGTCGCCCACGTCATGAAGCAGCGTTTCGGCGACCGCGACAGCGAACTGCCCGCCGACAACGAG CGGGCGCGCCGGTACGTCGCCAAGTACACGATCTGCCCGGCCGTCGCCCACGGCATCGACCACGTCGTCGGCTCCGTGGA GCCCGGCAAGCTCGCCGACCTGGTGCTCTGGGACCCCGCCTTCTTCGGGATCCGGCCCGCCGCCGTCATCAAGGGCGGCA TGGCCGTGTACGCGCCGCTCGGCGACGCGGGCGCGGCGATCCCCACCACCCAGCCGGTCCTCCTGCGCGCCACCTCCGCC GCCGAGGCCGCGCCGCACCTCTCGGTCAGCTTCGTCTCCCCGCTGGCCCTGGCCGACGGACTGGCCGAACGACTCGGCCT CGAACGCGAGTTGGTGGCCATACGCCCCACCCGGCATCTCACCAAGGCGGACCTGCCGAACAACACGGCGCTCCCGGCCA TCGACGTGGACCCCGAGACCTTCGCCATCCGCATCGACGGGGAGCTCGTCGAGCCCGCCCCCGCCGCCGAACTGCCGCTG GCCCAGCGGTACAGCATGTTCTGA Protein sequence : MAQLTRAAYASLYGPTTGDRIRLADTDLWIEVEEDRCFGGDEAVFGGGKSIRESMAQATASRAEGAPDLVITNAVVLDHW GVVKTDVGVRDGRIVALGRSGNPDISDGVHPDLVIGPGTDVISGEGRILTAGAVDTHVHFLMPETLHEALATGTTTVIGG GTGATEGSKATTVTPGAWNLAMMHRSLDRVPLNVMLFGKGSTVGEEALREAALSGAGGYKVHEDWGATPAAIDAALRAAD AYGLQVALHADSLNEVGYVEGTLDAIAGRGIHVFHAEGAGGGHAPDIITVASHPNILPASTNPTLPHTVNTVAEHLDMLM VCHHLNPRVPEDLAFAESRIRATTIAAEDVLHDIGALSITSSDAQAMGRIGEVVCRTWQVAHVMKQRFGDRDSELPADNE RARRYVAKYTICPAVAHGIDHVVGSVEPGKLADLVLWDPAFFGIRPAAVIKGGMAVYAPLGDAGAAIPTTQPVLLRATSA AEAAPHLSVSFVSPLALADGLAERLGLERELVAIRPTRHLTKADLPNNTALPAIDVDPETFAIRIDGELVEPAPAAELPL AQRYSMF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 3e-133 | 59 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 3e-133 | 59 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 8e-123 | 55 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-123 | 55 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 4e-123 | 55 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-123 | 55 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_001821748.1 | urease subunit alpha | VFG0270 | Protein | 3e-118 | 52 |
