Gene Information

Name : spaP (PMI2688)
Accession : YP_002152389.1
Strain : Proteus mirabilis HI4320
Genome accession: NC_010554
Putative virulence/resistance : Virulence
Product : surface presentation of antigens protein SpaP
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4790
EC number : -
Position : 2939875 - 2940534 bp
Length : 660 bp
Strand : -
Note : part of a type III secretory system probably involved in invasion into eukaryotic cells

DNA sequence : 
ATGGAAAGCTCAACACAATTAATCTTGATCCTAGCTCTTGCCACATTGGCTCCTTTTATTATTGCTGCAGGAACTTGTTA
TTTAAAGTTTTCTATCGTTTTAGTCATGACTCGTAATGCATTAGGTGTACAGCAAGTTCCTTCTAATATGGTACTTAATG
CTATCGCTTTAATGATGGCTCTTTTTGTTATGACACCAATTACTAAAAACATTTGTTACTATATTATTGAAAATAAAGTG
GATATGTCATCTCCAGATGCGATTGAGTCATTTTCAAATGAGGCGTTAGGCGATTATAAAAAATACCTTTATCATTACTC
AGATCCTGATTTATTAGCTTTTTTTGAACAAGCGCAAGAGAATAGACCGAATAGTGATGGTGATAAAGAAAACATAGAAA
ATTCACTCTTATCATTATTACCGGCATATGCACTTAGTGAGATAAAATCTGCTTTTATTATAGGTTTCTATCTTTATTTG
CCTTTTATTGTTATTGACTTAGTTGTCTCATGCATTTTATTAGCATTAGGTATGATGATGATGAGCCCTATTACATTATC
TGTACCTTTAAAACTTATTTTATTTATCGCTATGGATGGTTGGGGACTGTTATCTAAGGGACTCATTAATCAATATCTTG
ATTTGATGGCGGTGAACTAG

Protein sequence : 
MESSTQLILILALATLAPFIIAAGTCYLKFSIVLVMTRNALGVQQVPSNMVLNAIALMMALFVMTPITKNICYYIIENKV
DMSSPDAIESFSNEALGDYKKYLYHYSDPDLLAFFEQAQENRPNSDGDKENIENSLLSLLPAYALSEIKSAFIIGFYLYL
PFIVIDLVVSCILLALGMMMMSPITLSVPLKLILFIAMDGWGLLSKGLINQYLDLMAVN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
spaP NP_311752.1 surface presentation of antigens protein SpaP Not tested LIM Protein 1e-50 57
spaP NP_461811.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 3e-42 55
spaP NP_457284.1 secretory protein (associated with virulence) Virulence SPI-1 Protein 3e-42 55
spaP NP_806493.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 3e-42 55
spaP YP_217809.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 3e-42 55
epaP AAZ31293.1 EpaP Virulence ETT2 Protein 5e-49 55
ysaR AAS66846.1 YsaR Not tested SSR-1 Protein 3e-47 54
spaP AAS66865.1 SpaP Not tested SSR-2 Protein 9e-48 53
hrcR AAB06005.2 HrcR Virulence Hrp PAI Protein 4e-31 44
escR AAC38369.1 EscR Virulence LEE Protein 5e-30 43
escR AAK26700.1 EscR Virulence LEE Protein 9e-31 43
escR YP_003223490.1 T3SS structure protein EscR Virulence LEE Protein 1e-30 43
escR AAL57527.1 EscR Virulence LEE Protein 9e-31 43
escR YP_003232138.1 type III secretion system protein Virulence LEE Protein 1e-30 43
escR CAC81847.1 EscR protein Virulence LEE II Protein 9e-31 43
escR YP_003236103.1 T3SS structure protein EscR Virulence LEE Protein 1e-30 43
escR CAI43889.1 EscR protein Virulence LEE Protein 9e-31 43
escR NP_290283.1 type III secretion system protein Virulence LEE Protein 1e-30 43
escR AAC31528.1 L0049 Virulence LEE Protein 8e-31 43
escR AFO66317.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 1e-27 43
ECs4583 NP_312610.1 type III secretion system protein Virulence LEE Protein 1e-30 43
escR ACU09473.1 type III secretion system protein EscR Virulence LEE Protein 8e-31 43
escR AFO66400.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 1e-27 43
hrcR ABQ88359.1 HrcR Virulence Hrp PAI Protein 1e-24 42
hrpW AAB05075.1 HrpW Virulence Hrp PAI Protein 1e-24 42
unnamed AAL06354.1 EscR Virulence LEE Protein 8e-30 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
spaP YP_002152389.1 surface presentation of antigens protein SpaP VFG1773 Protein 3e-54 61
spaP YP_002152389.1 surface presentation of antigens protein SpaP VFG2455 Protein 7e-53 60
spaP YP_002152389.1 surface presentation of antigens protein SpaP VFG1012 Protein 2e-46 59
spaP YP_002152389.1 surface presentation of antigens protein SpaP VFG0551 Protein 9e-43 55
spaP YP_002152389.1 surface presentation of antigens protein SpaP VFG0827 Protein 4e-31 43
spaP YP_002152389.1 surface presentation of antigens protein SpaP VFG0715 Protein 3e-30 43
spaP YP_002152389.1 surface presentation of antigens protein SpaP VFG0044 Protein 4e-31 41