Gene Information

Name : guaA (PMI1545)
Accession : YP_002151276.1
Strain : Proteus mirabilis HI4320
Genome accession: NC_010554
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1638027 - 1639604 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAGCAAATATCCATAATCATCGCATTCTTATCCTTGATTTCGGTTCGCAATATACACAACTTATTGCTCGCCGTAT
TCGCGAAATCGGCGTTTATTGTGAACTCTGGGCATGGGATGTTACCGAAGAACAAATTCGTGAATTTAACCCCAATGGTA
TTATTCTGTCTGGTGGCCCTGAAAGTACTACAGAAGACAATAGCCCACGCGCTCCGGAATACGTCTTTAATGCGGGGGTG
CCGGTATTAGGCATCTGCTATGGCATGCAAACTATGTCTATGCAATTAGGCGGTGATGTTGAAGTCTCAGGTGAACGTGA
ATTTGGTTATTCACAAGTTGAGATCCGCGAAACCTGCGAACTGTTCCGTGATATTCAAGACTCCGTAAGTGAAGATGGCA
AACCTTTATTAGATGTATGGATGAGCCACGGTGATAAAGTTACGGCTATTCCCGCTGATTTTGTCACTATTGCTAGCACT
GAAACTTGCCCATTTGCGATTATGGCAAATGAAGAGAAGCGTTTCTATGGTGTACAGTTCCACCCAGAAGTTACCCATAC
CCATCAAGGTTTAGCCATTTTAAAACGCTTTGTGTTAGATATCTGTGGTTGTGACGCATTATGGACATCCGCGGCGATTA
TTGAAGATACTGTTGCTCGTTTAAAACAACAAATTGGCGACGATCACGTTATTCTCGCGCTATCGGGTGGTGTAGACTCT
TCTGTTACCGCATTATTATTAAATCGTGCCATTGGTAAACGCTTAACCTGTGTATTTGTTGATAATGGCTTATTACGCCT
TAACGAAGCCGAACAAGTTATGGCGATGTTTAAAGGCAAATTTGACCTCAATATTATCCATGTTGAAGCTGAAGATCGTT
TCTTAACTGCGCTAAAAGGTGAAAACGATCCGGAGAAAAAACGCAAAATTATCGGTCATACCTTCATTGAAATCTTTGAT
GAAGAAGCGGTTAAATTACCGCAAGTCAAATGGCTAGCACAAGGCACAATCTATCCTGATGTGATTGAATCAGCCGCATC
TGCAACAGGTAAAGCGCATGTGATCAAATCACACCATAACGTAGGTGGCTTACCTGAAGATATGAAGTTAGGTTTAGTGG
AGCCATTAAAAGAACTATTTAAAGATGAAGTGCGTAAAATCGGACTTGAGTTAGGTTTACCTTACGACATGCTATACCGT
CATCCATTCCCAGGACCAGGTTTAGGGGTGCGCGTATTGGGTGAAATCAAGAAAGAGTATTGTGATTTACTACGTCGTGC
TGACGCTATCTTTATTGAAGAGCTACATAAAGCCGATTTATACAATAAAGTCAGCCAAGCATTTACAGTATTCCTACCTG
TCCGTTCAGTGGGTGTTATGGGCGATGGCCGTAAATACGACTGGGTAGTTTCATTACGTGCTGTAGAAACCGTAGACTTT
ATGACTGCACATTGGGCACACCTACCTTACGATTTCTTAGGCCGTGTTTCTAACCGCATTATCAATGAAGTAAATGGTAT
TTCTCGCGTGGTTTATGATATCAGCGGAAAACCACCAGCAACGATTGAGTGGGAATAA

Protein sequence :
MTANIHNHRILILDFGSQYTQLIARRIREIGVYCELWAWDVTEEQIREFNPNGIILSGGPESTTEDNSPRAPEYVFNAGV
PVLGICYGMQTMSMQLGGDVEVSGEREFGYSQVEIRETCELFRDIQDSVSEDGKPLLDVWMSHGDKVTAIPADFVTIAST
ETCPFAIMANEEKRFYGVQFHPEVTHTHQGLAILKRFVLDICGCDALWTSAAIIEDTVARLKQQIGDDHVILALSGGVDS
SVTALLLNRAIGKRLTCVFVDNGLLRLNEAEQVMAMFKGKFDLNIIHVEAEDRFLTALKGENDPEKKRKIIGHTFIEIFD
EEAVKLPQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPEDMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEIKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-127 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-127 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-127 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-110 47