Gene Information

Name : thyA (Pnec_0387)
Accession : YP_001797282.1
Strain : Polynucleobacter necessarius STIR1
Genome accession: NC_010531
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 344900 - 345694 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGCGTCAATATCACGATCTCATGAAGGAAGTCCTCACCAAAGGGGTGCAAAAGTCCGATAGAACTGGGACTGGCACAGT
CTCGGTATTTGGACATCAAATGCGCTTTAATTTGTTAGATGGCTTTCCAATGGTGACCACCAAAAAACTGCACTTAAAGT
CCATCATCTATGAACTACTGTGGTTTCTCAAGGGAAGCACGAATAACAACTGGCTTAAAGAGCGTGGCGTTTCCATTTGG
AATGAATGGGCTGCACCGGATGGTGATTTAGGTCCTATCTATGGATATCAGTGGCGCTCCTGGCCTACACCTAATGGTCA
GCACATTGATCAAATCTCCGAAGTAGTTGAGACCATCAAAAAGAATCCAGACTCACGTCGCATTATTGTTTCAGCATGGA
ACGTAGCAGATATTCCCCGCATGGCTTTAGCGCCTTGCCATGCCTTCTTTCAGTTTTATGTAGCTGATGGCAAGTTGTCA
TGCCAACTCTATCAACGTAGCGCTGATATCTTCTTAGGCGTGCCATTTAATACTGCTAGTTATGCCCTACTTACTCACAT
AATGGCGCAGCAGTGCAATCTAGAGGTTGGCGACTTTATCTGGACAGGCGGTGATTGCCATCTTTATAGCAATCACCTTG
AGCAAGTAGATCTTCAGTTGTCACGGGATTTCTTCCCATTGCCTAAACTCAATATTTTGCGCAAACCAGATTCTATTTTT
GAATATGAGTTTGAAGACTTCGAAATCACGGGTTATGAATCTCATCCTCACATTAAAGCTCCTGTAGCCATATAA

Protein sequence :
MRQYHDLMKEVLTKGVQKSDRTGTGTVSVFGHQMRFNLLDGFPMVTTKKLHLKSIIYELLWFLKGSTNNNWLKERGVSIW
NEWAAPDGDLGPIYGYQWRSWPTPNGQHIDQISEVVETIKKNPDSRRIIVSAWNVADIPRMALAPCHAFFQFYVADGKLS
CQLYQRSADIFLGVPFNTASYALLTHIMAQQCNLEVGDFIWTGGDCHLYSNHLEQVDLQLSRDFFPLPKLNILRKPDSIF
EYEFEDFEITGYESHPHIKAPVAI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 4e-87 65