Gene Information

Name : guaA (Tneu_1516)
Accession : YP_001794886.1
Strain : Pyrobaculum neutrophilum V24Sta
Genome accession: NC_010525
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1349057 - 1350574 bp
Length : 1518 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGAGAAGGTTCTCGTCGTCAACTTCGGCGGGCAGTACGCACACCTTATAGCTAGGAGACTGCGGGAGAGGGCGATCTA
CACGGAGGTTGTAGCTCCCGAGGACGCCGTAGAGGCGGCCAAGTCGCAGGAGGTAAAGGCCGTAGTTCTCTCGGGAGGCC
CCAGCTCGGTGTACCAAGAAGGGGCGCCCGACGTCTCAAACGACCTTTTTGCCCTGGGGAAGCCCATCTTAGGCATCTGC
TACGGCCACCAGCTGATTGCCAAGAAGTTCGGGGGGGTGGTGGAGAGAGGTAAGGGCGAGTACGGGAAAACTCTGGTCAA
GGTTCTCGAGGACGACGTCATATTCAGAGGTTGGGAAAGGGAGGAGGTCGTCTGGATGAGCCACAGCGACTACGTGGCGA
AGCCCCCAGAGGGCTTCAAGGTGCTGGCGGTAAGCGAAAATGGGTATATAGCCGCCATGAAGAAAGGCAATATCTACGGC
GTGCAGTTCCACCCTGAGGTATCCCACACCCCCAAGGGCGGCCTTCTTCTGGAGAGGTTCGCCAGGGAGGTGGCTCGGGT
AGAGTCCATGTGGAGGCCGGAGGATCAGATTGGGAGAATCGTGAGCCAGATAAGGGAGGAGGTGAAAGACGGCGATGTGA
TCATAGGGGTGAGCGGGGGGATAGATAGCACGGTCACAGCCATCCTTGTCCACATGGCGGTTGGGGATAGGGCCAAGGCC
GTGTTTATCGACCACGGGCTCTTCAGAGAGGGGGAGCCGGAGAGGGTCGTGGCCCTGTTGAGCTCCCTCGGCATAAAAAC
CCACTATGTAGACGCCAGAGAGCGCTTCCTCGCCAGGCTAGAGGGCGTCTCAGACTGCGAGGAGAAGCGTAGGATTATCG
GGGAGACCTTCGCCGAGGTCTTCGCAGAGGCCATATCTCTCTTCCCGCAGGCGAAATACCTAGCCCAGGGCACGCTTTAC
CCCGACGTCATCGAGAGCGGGGCGGTAAAGGGGGCCGATAAGATCAAGAGCCACCACAACGTGGGTGGGATGCCGAAGTG
GTTCACCTTAAAGCTTGTGGAGCCGCTGAGGGAGTTCTACAAAGACGAGGTAAGGAGGTTGGCCAAGGCTCTTGGTCTAC
CCGACGAGGTGGTGTACCGACATCCCTTTCCAGGGCCTGGCCTTGCCGTGAGGATCATAGGCCCCTTTACCAGGGAAAAG
CTGGATATTGTGAGGAAGGCGTCTAAGATAGTGGAGGAGGAGCTCGGTAAAGAGGGGCTCCTCAGAGGCGTCTGGCAAGC
CTTCGCGGTCGTGGGCGACGATAGGTGGGTAGGGGTAAAGGGCGATAAACGCGCCCTCGGCTACGTCGTCACTGTCAGAG
TTGTAGAAAGCGAAGACGCTATGACCGCCGACTGGTCGCGGCTCCCCTACGAGGTGCTGGAGAGGATATCGGCGCGGATA
ACCTCGGAGATACCCCAAGTGACAATGGTGACCTACGCCATCACCACGAAACCTCCTTCCACAATAGAGCCCTGTTGA

Protein sequence :
MEKVLVVNFGGQYAHLIARRLRERAIYTEVVAPEDAVEAAKSQEVKAVVLSGGPSSVYQEGAPDVSNDLFALGKPILGIC
YGHQLIAKKFGGVVERGKGEYGKTLVKVLEDDVIFRGWEREEVVWMSHSDYVAKPPEGFKVLAVSENGYIAAMKKGNIYG
VQFHPEVSHTPKGGLLLERFAREVARVESMWRPEDQIGRIVSQIREEVKDGDVIIGVSGGIDSTVTAILVHMAVGDRAKA
VFIDHGLFREGEPERVVALLSSLGIKTHYVDARERFLARLEGVSDCEEKRRIIGETFAEVFAEAISLFPQAKYLAQGTLY
PDVIESGAVKGADKIKSHHNVGGMPKWFTLKLVEPLREFYKDEVRRLAKALGLPDEVVYRHPFPGPGLAVRIIGPFTREK
LDIVRKASKIVEEELGKEGLLRGVWQAFAVVGDDRWVGVKGDKRALGYVVTVRVVESEDAMTADWSRLPYEVLERISARI
TSEIPQVTMVTYAITTKPPSTIEPC

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 6e-102 47
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-102 47
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-102 47
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-100 47