Gene Information

Name : ureC (Lcho_1076)
Accession : YP_001790110.1
Strain : Leptothrix cholodnii SP-6
Genome accession: NC_010524
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 1145498 - 1147225 bp
Length : 1728 bp
Strand : -
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGGCAACGATCCCCCGCCGCGCCTATGCCGAGATGTTCGGCCCCACGATCGGCGACCGTCTGCGGCTGGCCGATACCGA
GCTGATCCTCGAGGTCGAGGACGATCTGACGCTGCGCGCCGGCGGCTACGGCGAAGAAGTCAAGTTCGGCGGCGGCAAGA
CCATCCGCGACGGCATGGGCCAGGGCCAGCGCGTCAACGGACCGGGCGCCGCCGACGCGGTCGACTGCGTCATCACCAAC
GCGCTGATCGTCGACCACTGGGGCATCGTCAAGGCCGACATCGGCCTGCGTGGCAACCGCATCGCCGCCATCGGCAAGGC
CGGCAACCCGGACATCCAGCCCGGCGTGGACATCGTCATCGGCCCGGGCACCGAGGTGATCGCAGCCGAGGGGCTGATCG
TCACGGCCGGCGGCATCGACAGCCACATCCACTGGATCTGCCCGCAGCAGATCGACGAGGCGCTGGCCTCGGGCGTGACC
ACCATGCTCGGCGGCGGCACCGGCCCGGCCACCGGCACCTTCGCCACCACCTGCACGCCCGGCCCCGAGAACATCGCGCG
CATGCTGCAGGCGGCCGACGCCTTCCCGATGAACCTGGGCTTCTTCGGCAAGGGCAACGCCAGCCGGCCCGAGGCGCTGC
GCCAGCAGGTCGACGCCGGCGCGATCGCGCTCAAGCTGCACGAGGACTGGGGCACCACGCCGGCGGCGATCGACTGCTGC
CTGAGCGTGGCCGAGCAGACCGACATCCAGGTCGCGATCCACACCGACACGCTCAACGAATCGGGCTTCGTCGAGGACAC
CGTGGCCGCGTTCAAGGGCCGCACCATCCACACCTTCCACACCGAAGGCGCCGGTGGCGGCCACGCGCCCGACATCATGA
AGGTGGTCGGCGAGGCCAACGTGCTGCCGTCGTCGACCAACCCGACGCGACCGTACACGGTCAACACGCTCGACGAACAC
CTCGACATGCTGATGGTGTGCCACCACCTCGACGCCGGCATCGCCGAGGACCTGGCCTTTGCCGAAAGCCGCATCCGCCG
CGAGACGATTGCCGCCGAGGACATCCTGCACGACCTGGGCGCCATCAGCATGATGAGCAGCGACAGCCAGGCGATGGGCC
GGGTCGGCGAGGTGGTGATCCGCACCTGGCAGACGGCGCACAAGATGAAGGTGCAGCGCGGCAAGCTGCCGGGTGACACC
GACCGCCACGACAACGCACGCATCAAGCGCTACATCGCCAAGTACACGATCAACCCGGCGCTGGCTCACGGCATGAGCCA
CGAGGTCGGCTCGATCGAGGTCGGCAAGTGGGCCGACCTGGTGTTCTGGAAACCGGCGTTCTTCGGCGTCAAGCCCAGCC
TGGTGCTCAAGGGCGGCTTCATCGCGCTGGCCGCGATGGGCGACCCCAACGCCAGCATCCCGACGCCGCAGCCGGTGCAC
TACCGGCCGATGTTCGGCAGTTTCGGCGGCGCGCTGGCGCGCACCTCGCTGACCTTCCTGTCACAGGCCGCACTGGCCGA
CGACGTGGGCACGCGCTACGGCCTGCACAAGCGGCTCGCCGCGGTGCGTGGCATCCGCAGCGTCAAGAAGGCCGACATGA
TCCACAACGGCGCCACGCCGGTGATGGAGATCGACGCGCAGACCTACAGCGTGCGCGCCGACGGCCAGCTGCTGACCTGC
GAACCGGCCCAGGTGCTGCCGATGGCGCAGCGTTATTTCCTGTTCTGA

Protein sequence :
MATIPRRAYAEMFGPTIGDRLRLADTELILEVEDDLTLRAGGYGEEVKFGGGKTIRDGMGQGQRVNGPGAADAVDCVITN
ALIVDHWGIVKADIGLRGNRIAAIGKAGNPDIQPGVDIVIGPGTEVIAAEGLIVTAGGIDSHIHWICPQQIDEALASGVT
TMLGGGTGPATGTFATTCTPGPENIARMLQAADAFPMNLGFFGKGNASRPEALRQQVDAGAIALKLHEDWGTTPAAIDCC
LSVAEQTDIQVAIHTDTLNESGFVEDTVAAFKGRTIHTFHTEGAGGGHAPDIMKVVGEANVLPSSTNPTRPYTVNTLDEH
LDMLMVCHHLDAGIAEDLAFAESRIRRETIAAEDILHDLGAISMMSSDSQAMGRVGEVVIRTWQTAHKMKVQRGKLPGDT
DRHDNARIKRYIAKYTINPALAHGMSHEVGSIEVGKWADLVFWKPAFFGVKPSLVLKGGFIALAAMGDPNASIPTPQPVH
YRPMFGSFGGALARTSLTFLSQAALADDVGTRYGLHKRLAAVRGIRSVKKADMIHNGATPVMEIDAQTYSVRADGQLLTC
EPAQVLPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 3e-176 71
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 3e-176 71
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-156 62
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-156 62
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-156 62
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-156 62

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_001790110.1 urease subunit alpha VFG0270 Protein 4e-141 59