Gene Information

Name : clpC (CLK_2956)
Accession : YP_001788851.1
Strain : Clostridium botulinum Loch Maree
Genome accession: NC_010520
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence MecB/ClpC
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : 3.4.21.-
Position : 3838857 - 3841292 bp
Length : 2436 bp
Strand : -
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGATGTTTGGAAGATTTACAGAAAGAGCTCAGAAAGTACTTATGAATGCTCAGGAAGAAGCAGAAAAATTTAAACATGG
ATATGTAGGCACAGAACATATTCTTTTAGGAATTTTAATAGAAGATGGAGTAGCTAAACAATTATTAAATAATTTTAGTA
TAACAGAAGATAAAGTTAGACAGTTAATAGAAAGATATGAAGGAAAAGGGGAAATGGATCTTTCTAAAAATGAGATTCCA
CTTACACCAAGAACAAAAAGGTTACTTGAAATGAGTTTATTAGAAGCTAGAAATTTAAATCATAATTATATAACCCCAGA
ACATATATTATTGGGATTAATAAGAGAAGCTGAAGGGGTAGCCTTTACCATTCTTTCTAATTTAGGCTTAGATGCTGAAA
GATTAAAAAAAGAGTTAATAAAGAATTTATCTGGGCAAGAAACCCCTAAAGATGAAGATAGTAAAAAAAGTTCTAAAAGC
TCTACTCCTACATTAGATCAATTTGGAAGAGATCTAACTGAAATGGCAGAAGAAGGGAAGGTTGACCCTGTTATTGGAAG
GGATAAAGAAACCCAGAGAGTTTTAGAAATATTATGTAGAAGAACTAAGAACAATCCTTGCTTAATAGGTGAACCAGGAG
TTGGAAAAACAGCAATAGCCGAAGGACTAGCTCAAAATATAATTAATGGAAATATACCAGAAATATTAAAAAGTAAAAGA
GTAGTTACATTAGATTTAACATCTATGATAGCAGGGGCTAAGTATAGGGGTGAATTTGAGGATAGATTAAAGAAAATAAT
GGAGGAAGTAAGAAGTTCTAAAGATACAATATTGTTTATAGATGAAATTCATACAATAGTTGGAGCTGGGGCAGCAGAAG
GTGCTATAGATGCGGCAAACATATTAAAACCAGCATTAGCGAGAGGAGAAATTCAATGCATAGGTGCAACTACACTAGAT
GAATATAGAAAGTATATAGAAAAGGATTCTGCTTTGGAGAGAAGATTCCAGCCTATAAACGTAGGAGAACCTACAAAAGA
AGAAACAATAGAAATTTTAAAAGGATTAAGAGATAAGTATGAAGCACATCATAGAGTTAAATTTACAGATGATGCTATAT
ATGCAGCAGTTAATTTATCTGATAGATATATAAGAGATAGATTTTTGCCAGATAAAGCGATAGATCTGATGGATGAAGCT
GGTTCCAAGGTTAGAATACAAAATTTAATTGCACCACCAGATTTGAAGAATATAGAAGAACAACTAGATAAAGTTGTTAA
AGAAAAAGAAGATGCAATAAGAGTACAGGATTTTGAAAAAGCTGCTAATTTAAGAGATAAAGAAAAAGAATTGAAAGAAA
AGTTAGAAGGATTGAAAAAGGATTGGAATGCAGAAAAAGAGGGTTCTAATCTAATTGTATCAGAACAACAAATAGCAGCA
GTAGTTTCAAATTGGACTAATATACCAGTTAATAAGCTTACTGAAAAGGAATCTGAAAGACTCTTAAAATTAGAAGATAT
TCTTCATAATAGGGTAATTGGCCAAGAAGAAGCTATTAAATCAGTATCAAGATCTGTAAGAAGAGCAAGAGTAGGCTTGA
AAGATCCAAAGAGACCAATAGGTTCATTTATATTTTTGGGACCAACAGGTGTAGGGAAAACTGAATTAACTAAAGCCTTA
GCAGAAGCTATGTTTGGAAATGAAAATAATATGATTAGGGTTGACATGTCAGAATATATGGAAAAACATTCAGTATCTAG
ATTAATAGGATCGCCCCCAGGATATGTAGGGCACGATGAAGGCGGTCAATTAACAGACAAGGTAAGGACAAATCCATATT
CAGTTGTTTTATTTGATGAAATAGAAAAAGCTCATCCAGAAGTGTTTAATATATTACTTCAAATATTAGAAGATGGAAGG
CTTACAGATGGAAAAGGAAAAACAGTAGATTTTAGAAATACTATAATCATAATGACATCTAATGTGGGAGCATCAACTAT
AAGTAGGCAAAAGACATTAGGTTTTAATACCTCCATAGAAGAAGAAAGAGAAACAGAATATGAAAAAATGAAGGATAACA
TTATGAATGAATTAAAACATTCATTTAGGCCAGAATTCTTAAATAGAATAGATGATATAATAGTTTTCCATCAATTAAGA
GAAGAGCATATTAGAGAAATAGTTAAACTTATGCTAAAAACTGTATCAAATAGAGTCAAAGATCAAGGAATAAAATTAGA
GTTTACAGAAGAAGCAGAAAAAATATTAGCAAAAGAAGGATACGATACTAATTATGGAGCGAGACCTTTAAGAAGAGCTA
TAACTAAAATTGTAGAAGATAAATTGTCAGAAGAAATATTAAAGGGAAATATTAAAAAAGGTGATTCAGTTAAAGTTAAT
ACAATTGAAGATGAATTAAATTTTTGTAAGATGTAA

Protein sequence :
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKQLLNNFSITEDKVRQLIERYEGKGEMDLSKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLKKELIKNLSGQETPKDEDSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIINGNIPEILKSKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLEDILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYVGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDELNFCKM

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 55

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_001788851.1 negative regulator of genetic competence MecB/ClpC VFG0079 Protein 0.0 59
clpC YP_001788851.1 negative regulator of genetic competence MecB/ClpC VFG0080 Protein 2e-150 52