Gene Information

Name : guaA (HSM_0746)
Accession : YP_001784084.1
Strain : Haemophilus somnus 2336
Genome accession: NC_010519
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 858746 - 860317 bp
Length : 1572 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAAATATCCATCACCATAAAATCCTCATTTTAGATTTCGGTTCACAATATACGCAACTTATCGCACGTCGTGTACG
TGAAATCGGGGTGTATTGCGAGCTTTGGGCTTGGGACGTTACGGAAGAACAAATTCGTGAGTTTAACCCAACAGGAATTA
TTCTTTCAGGCGGACCGGAAAGTACGACTGAAGCGAATAGTCCACGTGCAACTGAATACGTTTTCAATGCAGGTGTACCT
GTTTTAGGTATTTGCTACGGCATGCAAACCATGGCAATGCAGTTGGGCGGTTTAACAGAAACTTCTACGCATCGTGAGTT
TGGCTATGCTGAAGTTTCTCTACAAAATCCGACCGCACTTTTTGCAGATTTAAACGATGATCTGACCGCTTGCGATCCAA
AATTGGACGTTTGGATGAGCCACGGCGATAAAGTGACTCGCCTACCTGATAATTTCCAAATTACAGGCATGACCTCGACT
TGCCCGATCGCGGCTATGTCAGATGAAAGCCGTCGTTTCTATTGCGTGCAATTCCACCCCGAAGTTACCCACACAAAGTG
CGGTCAAAAATTACTGCAAAATTTTGTGGTAGATATTTGCGGTTGCGAAACCAATTGGACCGCAGAAAATATCATCGAAG
ATGCAGTGGCTCGCATTAAAGCACAAGTGGGCGATGATGAAGTAATTTTAGGCTTGTCAGGTGGCGTGGATTCATCTGTT
ACCGCACTTTTATTGCATCGTGCCATCGGTAAAAATTTACATTGTGTCTTTGTCGATAACGGCTTACTCCGTCTAAATGA
AGGCGATCAGGTCATGGAAATGTTCGGTGATAAATTCGGCTTGAATATTATTCGAGTAGAAGCAGAAGATCGCTTTTTAG
AAGCATTAAAAGGAATTGATGAACCGGAAGCAAAACGCAAAACTATCGGTAAAGTATTCGTTGATGTATTCGATGATGAA
GCAAAAAAATTAACTGACGTAAAATGGTTAGCTCAAGGTACGATTTACCCTGATGTTATCGAATCGGCAGCAAGCAAAAC
CGGAAAAGCCCATGTTATCAAATCTCACCACAATGTAGGGGGATTACCCGATTATATGAAATTAGGTTTAGTTGAGCCGT
TGCGTGAACTCTTCAAAGATGAAGTGCGTAAAATCGGCTTGGCACTCGGCTTGCCTGCGGAAATGCTTAACCGCCACCCA
TTCCCAGGCCCTGGATTAGGTGTACGTGTACTGGGTGAAATCAAAAAAGAATATTGCGATTTACTGCGTAAAGCCGATGC
AATTTTTATCGAAGAACTGCATAAAGCAGATTGGTACTACAAAGTCAGCCAAGCGTTCGGTGTCTTCTTGCCGGTAAAAT
CTGTTGGGGTAATGGGCGACGGTCGTAAATATGATTGGGTTATTAGCCTAAGAGCGGTCGAAACCATTGACTTTATGACC
GCACATTGGGCAAACCTACCTTATGATTTATTAGGCAAAATCTCAAATCGCATTATCAACGAAGTCAACGGCATCTCCCG
TGTAGTTTATGACATCTCAGGAAAACCACCAGCAACGATTGAGTGGGAGTAG

Protein sequence :
MTNIHHHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEEQIREFNPTGIILSGGPESTTEANSPRATEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSTHREFGYAEVSLQNPTALFADLNDDLTACDPKLDVWMSHGDKVTRLPDNFQITGMTST
CPIAAMSDESRRFYCVQFHPEVTHTKCGQKLLQNFVVDICGCETNWTAENIIEDAVARIKAQVGDDEVILGLSGGVDSSV
TALLLHRAIGKNLHCVFVDNGLLRLNEGDQVMEMFGDKFGLNIIRVEAEDRFLEALKGIDEPEAKRKTIGKVFVDVFDDE
AKKLTDVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHP
FPGPGLGVRVLGEIKKEYCDLLRKADAIFIEELHKADWYYKVSQAFGVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
AHWANLPYDLLGKISNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-129 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-129 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-129 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-110 48