Gene Information

Name : HSM_1021 (HSM_1021)
Accession : YP_001784351.1
Strain : Haemophilus somnus 2336
Genome accession: NC_010519
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1167566 - 1169005 bp
Length : 1440 bp
Strand : -
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
ATGTCTAGAAGACTAAGAAGAACAAAAATAGTATGTACACTGGGACCATCCACAGATCGAGGTAATAATTTAGAAAAAAT
TATTGTAGCCGGTGCAAATGTTGTTCGTATGAATTTTTCTCATGGTACACCAGAAGATCATCTTGCTCGTGCTGAAAAAG
TTCGTGAAATTGCTAAAAAATTAGGTAAAACTGTTGCAATTTTAGGAGATCTACAAGGTCCAAAAATTCGGGTATCTACT
TTTAAAGAGGGTAAAATTTTCTTAAATATTGGTGATAATTTTACTTTAGATGCTGATTTACCCAAAGGTGAAGGTAATCA
AGAAGCCGTAGGACTGGATTATAAAACATTACCACAAGATGTTGTTCCGGGCGATATTTTATTATTAGATGACGGACGTG
TTCAGTTAAAAGTGTTATCGACAGACAATACTAAAGTATTTACAGAAGTAATTGTTGGCGGTCCATTATCAAATAATAAA
GGTATCAATAAATTAGGTGGTGGGTTATCTGCTAACGCACTGACAGAAAAAGACAAAGAAGACATTATTTTAGCTGCACG
TATTGGTGTTGATTATCTTGCTGTTTCTTTCCCTCGTTCCAGTGCTGATTTAAATTATGCTCGTGAATTAGCTCAACAAG
CTGGTTTAAAAGCCAAAATTGTGGCTAAAGTTGAAAGAGCGGAGACTGTTATTGACGATGAGGCAATGGACGATATTATT
TTAGCTTCTGATGTAATTATGGTTGCTCGTGGTGATTTGGGTGTTGAAATTGGTGATCCGGAATTAGTCGGAATACAGAA
AAAATTAATTCGTCGTTCACGTCAGCTAAATCGTGTAGTGATTACCGCAACACAAATGATGGAATCTATGATTAGCAATC
CTATGCCAACTCGTGCCGAGGTGATGGATGTTGCCAATGCTGTATTAGATGGCACTGATGCCGTCATGCTTTCTGCGGAA
ACAGCAGCAGGTCAATACCCTTCAGAAACTGTTTCAGCAATGGCTAAAGTTTGTTTAGGTGCTGAAAAAATGCCTAGTGT
AAATATTTCTCGGCATCGCTTAGATAAAGAATTTGATACGATTGAAGAAACTATTGCGATGTCTACGATGTTTGCAGCCA
ACCATATGAAAGGTGTTGCAGCCATCATCGCAATGACAAGTAGTGGTCATACTGCAAAATTGATGTCTCGCATTAGTTCC
GGACTACCAATTTTTGCCCTTTCTCGAAATGAAAGTACGTTAAATTTATGTGCATTGTATCGTGGTGTTATTCCAATTCA
TTTTGATCAGGATAGTCGTACGCTTGAAGGATTAAAAGCAGCAATACAATCGCTAAAAGATAAAGGTTATTTAGTTTCCG
GTGATTTGGTTTTATTAACTCAAGGAGACCATTTAACATCAAATGGTACGACTACTTGCCGTGCTTTAGTGGTTGAATGA

Protein sequence :
MSRRLRRTKIVCTLGPSTDRGNNLEKIIVAGANVVRMNFSHGTPEDHLARAEKVREIAKKLGKTVAILGDLQGPKIRVST
FKEGKIFLNIGDNFTLDADLPKGEGNQEAVGLDYKTLPQDVVPGDILLLDDGRVQLKVLSTDNTKVFTEVIVGGPLSNNK
GINKLGGGLSANALTEKDKEDIILAARIGVDYLAVSFPRSSADLNYARELAQQAGLKAKIVAKVERAETVIDDEAMDDII
LASDVIMVARGDLGVEIGDPELVGIQKKLIRRSRQLNRVVITATQMMESMISNPMPTRAEVMDVANAVLDGTDAVMLSAE
TAAGQYPSETVSAMAKVCLGAEKMPSVNISRHRLDKEFDTIEETIAMSTMFAANHMKGVAAIIAMTSSGHTAKLMSRISS
GLPIFALSRNESTLNLCALYRGVIPIHFDQDSRTLEGLKAAIQSLKDKGYLVSGDLVLLTQGDHLTSNGTTTCRALVVE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 7e-78 49
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 2e-57 41
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-56 41
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-56 41
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-56 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HSM_1021 YP_001784351.1 pyruvate kinase VFG0479 Protein 4e-57 41