Gene Information

Name : M446_5059 (M446_5059)
Accession : YP_001771820.1
Strain : Methylobacterium sp. 4-46
Genome accession: NC_010511
Putative virulence/resistance : Virulence
Product : L-lysine 6-monooxygenase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG3486
EC number : 1.14.13.59
Position : 5542694 - 5544022 bp
Length : 1329 bp
Strand : -
Note : KEGG: oan:Oant_3254 L-lysine 6-monooxygenase (NADPH)

DNA sequence :
GTGACCGGATCTCCGCTGGATCTCGCCGGCATCGGCATCGGTCCCTTCAACCTCAGTCTCGCGGCCCAGGCCGACGCGGT
CGGCGACCTCGACGCGCGCTTCTTCGAGCGCGAGCCGGCCTTCGACTGGCACCCCGGCATGATGCTGCCGGGGGTGAGCC
TGCAGACCTCCTTCCTGAAGGACCTCGTCACGGCGACGAACCCGACGAGCCCGTGGAGCTTCATGGCCTACCTCGTGGCG
CAGAAGCGCTTCTACGAGTTCCTGAACGCCGATTTCGCCGAGGTTCCGCGCCGGGAATTCGCCCGCTACCTCGCCTGGGT
GGCGGCGCGGCTGCCGTCCCTGCGCATCGGCACGGCGGTGCGCGAGGTGACCTTCGCGGAGGACAGCTTCGTGCTCGCCT
GCGACGGTCCGCGGGCCGGCGGGCCCGTGCGCGCGCGCAACCTCGCGCTCGGCGTCGGCCTGCGTCCGGCGGTTCCGGAC
TTCGCCGCGAAGCTGCCGGAGCCGCAATGGTTCCACGCCTCGAAGGCCGCCTTCGCCCTCGACCGCACGGCCGGCCGGCG
CGTCGCGGTGGTGGGCGGCGGCCAGAGCGGGGCGGAGATCGTCCTCGACCTTCTCGGGCGGGGCCGCGACGCGCCCGCGC
GGGTGGACTGGATCAGCCGGCGCCCGAACTTCCTCCCCCTCGACGCGACCCCCTTCACCAACGAAGTGTTCACCCCGCAC
TACGTGGAGCGCTTCCGCGACCTGCCGGAGCCGCGGCGGCGGGCCATCGTGGCCCGCCAGAAGCTCGCCGGGGACGGCAT
CTCGGCCGAGACCCTGCGGGCGCTCTACCGCCGGCTCTACGCCCTGCGGCACCTGGAGCCGGAGGGGCCCGCGGTCGGCC
TCCTGCCGCACCGCGACGTGCGCGACGCGGACGCGACCGGGGGCGTCCCGCGGCTCGTGATGCGCAACGGCTTCGACGGG
GGGATCGAGGTGCTTCGCACGGAGGTGGTCATCCTCGCGACCGGCTACCGCTACGCCCTGCCCGACTGCCTCGCCCCGAT
CCGGCACCGGCTCGCCCTCGACGCGGACGGGCGCCCGCAGCCCTCCGCGGATTTCGCGATCCGCTGGGACGGGCCCGACC
ATTGCCGGATCTTCGCGCTCAATGCCGGGCTGACGAGCCACGGGATCGCCGAGCCGCAGCTGAGCCTGATGGCGTGGCGC
AGCGCGGTGATCGTCAACGCGCTCGCGGGGCGCCCCTGCTTCGACCTCGCTCAAGGCCCATCGCCCGTCGCGTGGTCCGG
CCCGCCCGAGCGGGCCTGGCGCGTCGACGCGTCCTGCGCGGAGGAGTGA

Protein sequence :
MTGSPLDLAGIGIGPFNLSLAAQADAVGDLDARFFEREPAFDWHPGMMLPGVSLQTSFLKDLVTATNPTSPWSFMAYLVA
QKRFYEFLNADFAEVPRREFARYLAWVAARLPSLRIGTAVREVTFAEDSFVLACDGPRAGGPVRARNLALGVGLRPAVPD
FAAKLPEPQWFHASKAAFALDRTAGRRVAVVGGGQSGAEIVLDLLGRGRDAPARVDWISRRPNFLPLDATPFTNEVFTPH
YVERFRDLPEPRRRAIVARQKLAGDGISAETLRALYRRLYALRHLEPEGPAVGLLPHRDVRDADATGGVPRLVMRNGFDG
GIEVLRTEVVILATGYRYALPDCLAPIRHRLALDADGRPQPSADFAIRWDGPDHCRIFALNAGLTSHGIAEPQLSLMAWR
SAVIVNALAGRPCFDLAQGPSPVAWSGPPERAWRVDASCAEE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
iucD NP_709457.1 lysine:N6-hydroxylase Virulence SHI-2 Protein 3e-68 41
iucD AAK71634.1 IucD Virulence SHI-3 Protein 2e-67 41
iucD AAD44749.1 IucD Virulence SHI-2 Protein 2e-68 41
iucD YP_002414043.1 L-lysine 6-monooxygenase Virulence Not named Protein 3e-68 41
iucD NP_839220.1 lysine:N6-hydroxylase Virulence SHI-2 Protein 3e-68 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
M446_5059 YP_001771820.1 L-lysine 6-monooxygenase VFG1084 Protein 1e-67 41
M446_5059 YP_001771820.1 L-lysine 6-monooxygenase VFG0618 Protein 1e-68 41
M446_5059 YP_001771820.1 L-lysine 6-monooxygenase VFG0937 Protein 1e-68 41