Gene Information

Name : ureC (UPA3_0451)
Accession : YP_001752517.1
Strain : Ureaplasma parvum ATCC 27815
Genome accession: NC_010503
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 493578 - 495374 bp
Length : 1797 bp
Strand : -
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGTTTAAAATTTCAAGAAAAAATTATTCAGATTTATACGGTATTACAACTGGTGATAGCGTTAGATTAGGAGATACAAA
TCTTTGAGTTAAAGTTGAAAAAGACTTAACTACTTATGGTGAAGAATCTGTTTTTGGTGGTGGAAAAACCCTACGTGAAG
GTATGGGAATGAATTCTACTATGAAGTTAGATGATAAATTAGGTAATGCTGAAGTAATGGATTTAGTTATTACAAATGCA
CTAATTGTTGATTATACAGGTATTTATAAAGCAGATATTGGTATTAAAAATGGAAAAATTGCTGCGATTGGTAAATCTGG
AAATCCACATTTAACAGATAATGTTGATATGATTGTGGGTATCTCAACTGAAATTTCAGCTGGTGAGGGTAAAATTTATA
CAGCTGGTGGTTTAGATACTCACGTTCACTGACTAGAACCAGAAATAGTTCCTGTTGCATTAGATGGTGGTATTACAACT
GTTATTGCTGGTGGTACAGGTATGAATGATGGTACAAAAGCCACAACTGTTTCACCTGGTAAATTTTGAGTTAAATCAGC
TTTACAAGCAGCTGATGGATTATCAATTAATGCCGGTTTTTTAGCTAAAGGTCAAGGTATGGAAGATCCAATTTTTGAGC
AAATTGCTGCTGGAGCTTGTGGACTTAAAATCCATGAAGACTGAGGGGCAACAGGAAATGCGATTGATTTAGCATTAACA
GTTGCTGATAAAACTGATGTAGCTGTTGCTATTCATACAGATACATTAAATGAAGCTGGATTTGTAGAACATACAATTGC
AGCTATGAAAGGGCGAACAATTCATGCTTATCATACAGAAGGTGCTGGTGGAGGGCATGCTCCAGATATTCTAGAAACTG
TTAAATATGCCCATATTTTACCAGCTTCTACAAACCCAACAATTCCTTATACAGTAAATACAATTGCTGAACATTTAGAT
ATGTTAATGGTATGTCACCACTTAAATCCTAAGGTTCCAGAAGATGTTGCTTTTGCTGATTCACGTATTCGTAGCCAAAC
AATTGCAGCTGAAGACTTATTGCACGATATGGGTGCAATTTCAATTATGTCATCAGATACATTAGCTATGGGACGTATTG
GCGAAGTTGCAACTCGTACATGACAAATGGCTCACAAAATGAAAGCACAATTTGGATCATTAAAAGGTGATAGTGAATTC
AGTGATAACAATCGTGTAAAACGTTATATTTCTAAATATACAATTAACCCAGCTATTGCACATGGTGTTGATTCTTATAT
TGGTTCACTAGAAGTTGGTAAATTAGCTGATATTGTTGCTTGAGAACCTAAATTCTTTGGTGCAAAACCTTATTATGTTG
TAAAAATGGGTGTAATCGCTCGTTGTGTAGCAGGTGATCCAAATGCTTCAATTCCAACATGCGAACCTGTAATTATGCGT
GACCAATTTGGAACTTATGGACGTTTGTTAACTAATACATCAGTAAGTTTTGTTTCAAAAATTGGGTTAGAAAATGGCAT
TAAAGAGGAATATAAATTAGAAAAAGAATTATTACCAGTTAAAAATTGCCGTTCAGTAAATAAAAAGAGTATGAAATGAA
ACTCTGCGACTCCAAATTTAGAAGTTGATCCGCAAACTTTTGATGCTGCTGTTGATTTTAATGATTTAGAAAATTGACTA
GAACAATCAGCTTCTGAATTAGCTAAAAAATTAAAAAAGACTTCAAGTGGCAAATATATACTTGATGCTGAACCTTTAAC
AGAAGCGCCATTAGCACAAAGATATTTCTTATTTTAA

Protein sequence :
MFKISRKNYSDLYGITTGDSVRLGDTNLWVKVEKDLTTYGEESVFGGGKTLREGMGMNSTMKLDDKLGNAEVMDLVITNA
LIVDYTGIYKADIGIKNGKIAAIGKSGNPHLTDNVDMIVGISTEISAGEGKIYTAGGLDTHVHWLEPEIVPVALDGGITT
VIAGGTGMNDGTKATTVSPGKFWVKSALQAADGLSINAGFLAKGQGMEDPIFEQIAAGACGLKIHEDWGATGNAIDLALT
VADKTDVAVAIHTDTLNEAGFVEHTIAAMKGRTIHAYHTEGAGGGHAPDILETVKYAHILPASTNPTIPYTVNTIAEHLD
MLMVCHHLNPKVPEDVAFADSRIRSQTIAAEDLLHDMGAISIMSSDTLAMGRIGEVATRTWQMAHKMKAQFGSLKGDSEF
SDNNRVKRYISKYTINPAIAHGVDSYIGSLEVGKLADIVAWEPKFFGAKPYYVVKMGVIARCVAGDPNASIPTCEPVIMR
DQFGTYGRLLTNTSVSFVSKIGLENGIKEEYKLEKELLPVKNCRSVNKKSMKWNSATPNLEVDPQTFDAAVDFNDLENWL
EQSASELAKKLKKTSSGKYILDAEPLTEAPLAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 5e-142 56
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 5e-143 56
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 5e-143 56
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 5e-143 56
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 7e-130 55
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 7e-130 55

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_001752517.1 urease subunit alpha VFG0270 Protein 1e-130 60