Gene Information

Name : murD (EcSMS35_0093)
Accession : YP_001742210.1
Strain : Escherichia coli SMS-3-5
Genome accession: NC_010498
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : 6.3.2.9
Position : 103720 - 105036 bp
Length : 1317 bp
Strand : +
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGGCTGATTACCAGGGTAAAAATGTCGTCATTATCGGCCTGGGCCTCACCGGGCTTTCTTGCGTGGACTTTTTCCTCGC
TCGCGGTGTGACGCCGCGCGTTATGGATACGCGTATGACACCGCCTGGCCTGGATAAATTACCCGAAGCTGTAGAACGCC
ACACGGGCGGTCTGAATGATGAATGGCTGATGGCGGCCGATCTGATTGTCGCCAGTCCCGGTATTGCACTGGCGCATCCA
TCCTTAAGCGCTGCCGCTGATGCCGGAATCGAAATCGTTGGCGATATCGAGCTGTTCTGTCGTGAAGCACAAGCACCGAT
TGTGGCGATCACCGGTTCTAACGGCAAAAGCACGGTCACCACGCTAGTGGGTGAAATGGCGAAAGCGGCGGGGGTTAACG
TTGGTGTGGGTGGCAATATTGGCCTGCCTGCGTTGATGCTGCTGGATGATGAGTGCGAACTGTACGTGCTGGAGCTGTCG
AGCTTCCAGCTTGAAACCACCTCCAGTTTACAGGCGGTAGCAGCGACCATTCTGAACGTAACTGAAGATCATATGGATCG
CTATCCGTTTGGTTTACAACAGTATCGTGCAGCAAAACTGCGCATTTACGAAAACGCAAAAATTTGCGTGGTTAATGCTG
ATGATGCCTTAACAATGCCGATTCGCGGTGCGGATGAACGCTGCGTCAGCTTTGGCGTCAACATGGGTGACTATCACCTG
AATCATCAGCAGGGTGAAACCTGGCTGCGGGTGAAGGGCGAGAAAGTGCTGAACGTGAAAGAAATGAAACTTTCCGGGCA
GCATAACTACACCAATGCACTGGCAGCTCTGGCACTGGCAGATGCCGCTGGTTTGCCGCGCGCCAGCAGCCTGAAAGCGT
TAACCACATTCACTGGTCTGCCGCATCGCTTTGAAGTTGTGCTGGAGCATAACGGTGTGCGCTGGATTAACGATTCAAAA
GCGACCAACGTCGGCAGTACGGAAGCGGCACTGAATGGCCTGCACGTAGACGGCACGCTGCATTTGTTGCTGGGCGGCGA
TGGTAAATCGGCAGATTTTAGCCCACTGGCGCGTTACCTGAATGGCGATAACGTACGTCTGTATTGTTTCGGTCGGGACG
GCGCGCAGCTGGCGGCGCTACGCCCGGAAGTGGCAGAACAAACCGAAACCATGGAACAGGCGATGCGCTTGCTGGCTCCG
CGTGTTCAGCCGGGCGATATGGTTCTGCTCTCCCCGGCCTGTGCCAGCCTTGATCAGTTCAAGAACTTTGAACAACGAGG
CAATGAGTTTGCCCGTCTGGCGAAGGAGTTAGGTTGA

Protein sequence :
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGGLNDEWLMAADLIVASPGIALAHP
SLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELS
SFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKICVVNADDALTMPIRGADERCVSFGVNMGDYHL
NHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSK
ATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAP
RVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 3e-53 45
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 3e-53 45