Gene Information

Name : kpsC (EcSMS35_3223)
Accession : YP_001745206.1
Strain : Escherichia coli SMS-3-5
Genome accession: NC_010498
Putative virulence/resistance : Virulence
Product : polysialic acid capsule polysaccharide export protein KpsC
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG3563
EC number : -
Position : 3294939 - 3296972 bp
Length : 2034 bp
Strand : +
Note : identified by similarity to SP:P42217; match to protein family HMM PF05159

DNA sequence :
ATGATTGGCATTTACTCGCCTGGCATCTGGCGTATTCCGCATCTGGAGAAATTTCTGGCGCAACCGTGCCAGAAACTTTC
TCTGCTGCGTCCTGTTCCGCAAAACGTCGATGCTATCGCCGTGTGGGGACATCGTCCCAGCGCGGCGAAACCAGTCGCCA
TCGCCAAAGCCGCGGGAAAACCCGTCATTCGTCTGGAAGATGGATTTGTGCGTTCGCTGGGTCTTGGCGTCAATGGCGAG
CCGCCGCTTTCTCTGGTGGTGGATGATTGTGGCATTTACTACGATGCCAGCAAGCCTTCAGCACTGGAGAAACTGGTACA
GGATAAAGCCGGAAATACAGCTCTGATAAGCCAGGCCAGAGAAGCGATGCACACCATCGTGACCGGGGATTTGTCGAAAT
ATAACCTGGCACCTGCGTTTGTGGCTGATGAGTCTGAACGTTCAGACATCGTTCTGGTTGTCGATCAGACATTTAATGAT
ATGTCAGTGACGTATGGCAATGCTGGCCCGCATGAGTTTGCTGCCATGCTGGAAGCCGCGATGGCGGAAAATCCTCAAGC
CGAAATTTGGGTGAAGGTGCACCCAGATGTACTGGAAGGAAAAAAAACAGGTTATTTCGCCGATCTGCGCGCCACGCAAC
GAGTACGTTTAATTGCCGAGAATGTCAGCCCGCAGTCGCTGTTGCGACACGTTTCCCGGGTTTACGTCGTGACCTCCCAG
TACGGCTTTGAAGCCTTGCTGGCAGGAAAACCAGTAACATGTTTCGGCCAGCCCTGGTATGCAGGCTGGGGCTTAACCGA
CGATCGCCATCCGCAGTCCGCTTTGTTATCTGCCCGACGCGGTTCTGCCACGCTGGAGGAACTTTTTGCCGCTGCATACC
TGCGTTACTGTCGCTATATCTACCCGCAAACGGGAGAAGTAAGCAATCTATTTACCGTGCTGCAATGGCTGCAATTACAA
CGTCGACATCTGCAACAGCGTAATGGTTATTTATGGGCGCCAGGCTTAACGCTGTGGAAGTCAGCGATCCTGAAACCTTT
CTTGCAAACGGCAACAAACCGGCTGAGTTTTTCACGTCGCTGTACTGCGGCGAGCGCCTGCGTGGTATGGGGTGTAAAGG
GAGAACAGCAATGGCGAGCCGAAGCGCAGCGAAAATCACTGCCGTTATGGCGAATGGAAGATGGTTTTCTGCGTTCATCC
GGACTTGGCTCTGACCTGCTGCCGCCGCTATCGCTGGTGCTGGATAAACGCGGTATTTACTATGACGCCACGCGCCCCAG
CGATCTGGAAGTGCTGCTGAATCATAGCCAGCTAACGCTGGCGCAGAAGATGCGAGCTGAAAAATTACGCCAGCGACTGG
TTGAAAGCAAACTGAGTAAGTACAACCTGGGAGCCGATTTCTCTCTACCAGCCGAAGCCAAAGATAAAAAAGTTATCCTG
GTGCCGGGTCAGGTAGAAGACGATGCCTCAATTAAAACCGGCACCGTTTCTATTAAGAGCAACCTTGAGTTATTACGCAC
AGTACGCGAGCGTAATCCGCACGCTTACATTATTTATAAACCGCACCCGGATGTACTGGTGGGGAATCGCAAGGGCAATA
TTCCGACAGAACTAATTGCTGAACTCGCTGATTATCAGGCACTGGACGCAGATATTATTCAATGCATTCTGCGCGCAGAT
GAAGTGCACACCATGACATCATTGTCCGGGTTTGAAGCGTTATTACATGGCAAGCACGTACATTGTTACGGCCTGCCCTT
CTATGCCGGTTGGGGTTTAACCGTCGATGAACATCGCTGCCCGCGTCGCGAGCGAAAATTAACGTTAGCGGATTTGATCT
ATCAGGCGCTGATTGTTTATCCAACCTATATCCACCCAACATGGCTACAACCTATTACGGTAGAAGAAGCTGCGGAATAT
TTAATCAAGACGCCGCGCAAGCCGATGTTTATTACCCGAAAAAAAGCGGTAATACGCTATTACCGCAAATTAATTATGTT
CTGCAAGGTCAGATTTGGCCAAACAATTTCATAG

Protein sequence :
MIGIYSPGIWRIPHLEKFLAQPCQKLSLLRPVPQNVDAIAVWGHRPSAAKPVAIAKAAGKPVIRLEDGFVRSLGLGVNGE
PPLSLVVDDCGIYYDASKPSALEKLVQDKAGNTALISQAREAMHTIVTGDLSKYNLAPAFVADESERSDIVLVVDQTFND
MSVTYGNAGPHEFAAMLEAAMAENPQAEIWVKVHPDVLEGKKTGYFADLRATQRVRLIAENVSPQSLLRHVSRVYVVTSQ
YGFEALLAGKPVTCFGQPWYAGWGLTDDRHPQSALLSARRGSATLEELFAAAYLRYCRYIYPQTGEVSNLFTVLQWLQLQ
RRHLQQRNGYLWAPGLTLWKSAILKPFLQTATNRLSFSRRCTAASACVVWGVKGEQQWRAEAQRKSLPLWRMEDGFLRSS
GLGSDLLPPLSLVLDKRGIYYDATRPSDLEVLLNHSQLTLAQKMRAEKLRQRLVESKLSKYNLGADFSLPAEAKDKKVIL
VPGQVEDDASIKTGTVSIKSNLELLRTVRERNPHAYIIYKPHPDVLVGNRKGNIPTELIAELADYQALDADIIQCILRAD
EVHTMTSLSGFEALLHGKHVHCYGLPFYAGWGLTVDEHRCPRRERKLTLADLIYQALIVYPTYIHPTWLQPITVEEAAEY
LIKTPRKPMFITRKKAVIRYYRKLIMFCKVRFGQTIS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsC YP_854335.1 capsule polysaccharide export protein KpsC Not tested PAI I APEC-O1 Protein 0.0 97
kpsC AAZ04470.1 capsule polysaccharide export protein Virulence PAI I APEC-O1 Protein 0.0 97
kpsC CAE85214.1 KpsC protein Virulence PAI V 536 Protein 1e-174 93
lipA NP_273145.1 capsule polysaccharide modification protein Not tested IHT-A Protein 1e-126 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
kpsC YP_001745206.1 polysialic acid capsule polysaccharide export protein KpsC VFG0259 Protein 5e-127 51
kpsC YP_001745206.1 polysialic acid capsule polysaccharide export protein KpsC VFG0704 Protein 4e-104 47
kpsC YP_001745206.1 polysialic acid capsule polysaccharide export protein KpsC VFG0692 Protein 3e-117 47