Gene Information

Name : EcSMS35_3128 (EcSMS35_3128)
Accession : YP_001745142.1
Strain : Escherichia coli SMS-3-5
Genome accession: NC_010498
Putative virulence/resistance : Virulence
Product : bifunctional enterobactin receptor/adhesin protein
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG4771
EC number : -
Position : 3214175 - 3216262 bp
Length : 2088 bp
Strand : -
Note : IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor

DNA sequence :
ATGCGAGTAACCACTCTGGCTTCAGTAGCCATCCCTTGTCTCGGGTTTTCAGTCAGCAGTATGGCTGCGGAAGATGTGAT
GGTAGTCACGGCGTCTGGCTATGAAAAAAAATTAACCAGTGCAGCTGCGAGTGTTTCAGTGATCAGCCAGGAGGATTTGC
GATCCAGCCAGTATCATGATCTGGGGGAGGCACTGAGATCCGTAGAGGGGGTGGATGTTGAAAGCGGTACGGGTAAAACA
GGTGGGCTGGAAATCAGCATCCGCGGAATGCCTGCCAGTTATACGCTGATACTGATCGATGGTGTCCGTCAGGGCGGGAG
CAGTGACGTAACCCCAAACGGTTATGCTGCCATGAATACGGGTTTTATGCCACCTCTGGCCGCCATCGAACGTATTGAGA
TTATCAGGGGCCCCATGTCCACTCTGTACGGCTCTGATGCCATGGGGGGCGTGGTGAATATCATCACCAAAAAGAATGCA
GACAAATGGCGCTCTTCGGTTAATGCCGGGCTGAACCTGCAGGAAAGTAACAAATGGGGGAACAGCAGCCAGTTTAATTT
CTGGAGCAGCGGTCCCCTTGTGGATGATTCACTCAGCCTTCAGGTACGTGGCAGCACACAGCAGCGTCAGGGCTCATCGG
TCACATCACTGAGCGACACCTCAGCTACGCGTATCCCTTATCCCACGGAATCACAGAATTATAATGCAGGTGGTCGTCTT
GACTGGAAAGCGACGGACAAGGATGTACTCTGGATTGATATGGATATCGCCCGGCAGCGTTATGATAACCGAGATGGCCA
GCTGGGCAGTCTGACGGGCGGTTATGATCGCACCCTGCGCTATGAGCGTAATAAAATTTCAGCAGGCTATGATCATACAT
TCACCTTCGGAGCCTGGAAGTCATCCCTGAACTGGAATGAGACGGAAAATAAAGGCCGTCAGCTTGTACGTAGCGTACTG
CAGCGTGATAAATGGGGGCTTGCCGGCCAGCCGAGGGAGCTTAAGGAGTCGAATCTTATCCTGAGCTCATTACTGTTTGC
ACCTCTGGGGGAATCACACAAGGTTACCGTCGGTGGTGAGTATCAGAACTCCTCCATGAAAGACGGGGTTGTTCTCGCCA
GTACTGGTGAAACCTTCCGTCAGAAAAGCTGGTCGGCATTTGTTGAGGATGAGTGGTATATCACGGATGCATTTGCACTG
ACTGCGGGTAGCCGCTATGAACGCTATGAGGTGTTCGGAGGACACTTCAGTCCCCGGGCATATATGGTCTGGGATGTGAC
TGATGCGTGGACGCTGAAAGGTGGGGTGACCACGGGATATAAGGCGCCCAGCATGGGGCAGTTACATAAGGGGATCAGCG
GTGTGTCCGGTCAGGGGCGTACGAATCTTCTCGGTAACCCGGACCTGAAGCCGGAGGAGAGTGTCAGTTATGAAGCGGGC
GTGTATTACGATAATCATGCCGGTCTGAACGCCAATATCACGGGCTTTATGACAGAATTCTCCAACAAGATCGTATCTTA
TTCCATTGATGATAATACCCGCAGCTACACAAACAGCGGAAAGGCCAGGACTCAGGGCGTGGAATTTGCCGGCACACTGC
CTCTGTTGTCAGAGGATGTGACTCTGTCTCTGAATTATACCTGGACGCAGAGTGAACAACGGGATGGGGATAATAAAGGT
GCACCACTGAGTTACACCCCTGAGCATATGGTGAATGCGAAACTGAACTGGCAGATTACTGAAGAGGTGACATCATGGCT
GGGTGCCCGTTACCGCGGGAAAACGCCACGTTTCACCCAGAATTATTCGTCACTCTCAGCTGTACAGAAGAAAGTGTATG
ATGAGAAAGGTGAATATCTGAAAGCCTGGACGGTACTGGATGCGGGCATGTCGTGGAAAGTGACGGATGCACTGATGCTG
AATGCAGCGGTGAATAATGTGCTTAACAAGGATTACAGTGACGTAAGTCTGTATCGTGCCGGCAGTGGTACGCTTTATGC
GGGTGATTACTTCCAGACGGGGGCATCGACAACGGGTTATGTGATACCTGAGAGAAATTACTGGATGTCGCTGAACTATC
AGTTCTGA

Protein sequence :
MRVTTLASVAIPCLGFSVSSMAAEDVMVVTASGYEKKLTSAAASVSVISQEDLRSSQYHDLGEALRSVEGVDVESGTGKT
GGLEISIRGMPASYTLILIDGVRQGGSSDVTPNGYAAMNTGFMPPLAAIERIEIIRGPMSTLYGSDAMGGVVNIITKKNA
DKWRSSVNAGLNLQESNKWGNSSQFNFWSSGPLVDDSLSLQVRGSTQQRQGSSVTSLSDTSATRIPYPTESQNYNAGGRL
DWKATDKDVLWIDMDIARQRYDNRDGQLGSLTGGYDRTLRYERNKISAGYDHTFTFGAWKSSLNWNETENKGRQLVRSVL
QRDKWGLAGQPRELKESNLILSSLLFAPLGESHKVTVGGEYQNSSMKDGVVLASTGETFRQKSWSAFVEDEWYITDAFAL
TAGSRYERYEVFGGHFSPRAYMVWDVTDAWTLKGGVTTGYKAPSMGQLHKGISGVSGQGRTNLLGNPDLKPEESVSYEAG
VYYDNHAGLNANITGFMTEFSNKIVSYSIDDNTRSYTNSGKARTQGVEFAGTLPLLSEDVTLSLNYTWTQSEQRDGDNKG
APLSYTPEHMVNAKLNWQITEEVTSWLGARYRGKTPRFTQNYSSLSAVQKKVYDEKGEYLKAWTVLDAGMSWKVTDALML
NAAVNNVLNKDYSDVSLYRAGSGTLYAGDYFQTGASTTGYVIPERNYWMSLNYQF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
iha AAF36432.2 adhesin Virulence TAI Protein 0.0 91
c3610 NP_755485.1 bifunctional enterobactin receptor/adhesin protein Not tested PAI I CFT073 Protein 0.0 91
ECUMN_3356 YP_002414032.1 bifunctional enterobactin receptor/adhesin protein Virulence Not named Protein 0.0 91
Z1178 NP_286713.1 bifunctional enterobactin receptor/adhesin protein Virulence TAI Protein 0.0 91
Z1617 NP_287121.1 bifunctional enterobactin receptor/adhesin protein Not tested TAI Protein 0.0 91
r4 AAC61730.1 exogenous ferric siderophore receptor R4 Not tested PAI I CFT073 Protein 0.0 91
unnamed CAC39288.1 hypothetical protein Not tested LPA Protein 0.0 90

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
EcSMS35_3128 YP_001745142.1 bifunctional enterobactin receptor/adhesin protein VFG1731 Protein 0.0 91