Gene Information

Name : flu1 (EcSMS35_2249)
Accession : YP_001744298.1
Strain : Escherichia coli SMS-3-5
Genome accession: NC_010498
Putative virulence/resistance : Virulence
Product : antigen 43
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG3468
EC number : -
Position : 2267288 - 2270134 bp
Length : 2847 bp
Strand : -
Note : identified by match to protein family HMM PF03212; match to protein family HMM PF03797; match to protein family HMM TIGR01414

DNA sequence :
ATGAAACGACATCTGAACACCAGCTACAGGCTGGTATGGAATCACATTACGGGCACCCTGGTGGTGGCTTCCGAACTGGC
CCGCTCACGGGGAAAACGCGCCGGTGTGGCGGTTGCGCTGTCTCTTGCTGCTGTCACGCCAGTCCCGGCACTGGCTGCTG
ACACGGTTGTAGAGGCGGGAGAAACCGTGAACGGCGGAACACTGACAAATCATGACAACCAGATTGTCTTCGGTACGACC
AACGGAATGACCATCAGTACCGGGCTGGAGTATGGGACGGATAACGAGGCCAATACCGGCGGGCAATGGGTACAGGATGG
CGGCACAGCCAGTAATACCACCATCAGCAGCGGCGGGCTCCAGTTTGTAGGTGCCGGGGGAAAGGCTACAGACACAATAA
TCAATGAAGGAGGCGGACAAAGCCTGAAGGGACTGGCACTGAACACCACGCTGAATGGTGGCGAGCAGTGGATGCATGAA
GGTGCGATAGCCACAGGAACCGTCATTAATGATAAGGGCTGGCAGGTCGTCAAACCCGGCGCAGTGGCAACAGACACCGT
TGTGAATACCGGCGCAGAAGGAGGACCGGATGCAGAAAATGGTGATACCGGGCAGTTTGTTCGCGGAAATGCCGTACGTA
CCACCATCAATAAAAATGGTCGTCAGATTGTGACTGTTGAAGGAACAGCAAATACCACTGTGGTTTATGCCGGCGGCGAC
CAGACGGTACATGGCCACGCACTGGATACCACGCTGAATGGCGGTAACCAGTATGTACACAACGGCGGTACAACGTCTGA
CACTGTTGTGAACAGTGACGGCTGGCAGATTATCAAGGAAGGTGGTCTGGCGGATTTCACCACCGTTAACCAGAAAGGCA
AACTGCAGGTGAACGCCGGTGGTACAGCCACGAATGTCACCCTGAAGCAGGGAGGCGCACTGGTCACCAGTACGGCGGCA
ACCGTCACCGGCAGCAACCGTCTGGGCAATTTCGCGGTGGAAAACGGTAAGGCTGACGGTGTTGTTCTGGAGTCCGGCGG
TCGTCTGGATGTACTGGAGGGTCATTCAGCGCAGAAAACACGGGTGGATGACGGCGGTACCCTGGCAGTGTCTGCCGGTG
GTAAGGCGACAGGTGTCACCATGACATCCGGTGGTGCCCTGATTGCAGACAGTGGTGCCACTGTTGAGGGGACCAATGCC
AGCGGTAAGTTCAGTATTGATGGCATATCCGGTCAGGCCAGCGGCCTGCTGCTGGAAAATGGCGGCAGCTTTACGGTTAA
TGCCGGGGGACAGGCTGGCAACACCACTGTCGGACATCGTGGAACACTGACGCTGGCTGCCGGGGGAAGTCTGAGTGGCA
GAACACAGCTCAGTAAAGGCGCCAGCATGGTACTGAATGGTGATGTGGTCAGTACCGGCGATATTGTTAACGCAGGGGAG
ATTCGCTTTGATAATCAGACGACACAGGATGCCGTCCTGAGCCGTGCTGTTGCAAAAGGCGACGCCCCGGTAACGTTCCA
TAAACTGACCACCAGTAACCTCACCGGTCAGGGTGGCACCATCAATATGCGTGTTCGCCTTGATGGCAGCAATGCCTCTG
ACCAGCTGGTGATTAATGGTGGTCAGGCAACCGGCAAAACCTGGCTTGCGTTCACAAATGTCGGAAACAGTAACCTCGGG
GTGGCAACTTCCGGACAGGGTATCCGGGTTGTGGATGCACAGAATGGTGCCACCACAGAAGAAGGTGCGTTTGCCCTGAG
TCGCCCGCTTCAGGCCGGTGCCTTTAACTACACCCTGAACCGTGACAGCGATGAAGACTGGTACCTGCGCAGTGAAAATG
CTTATCGTGCTGAAGTCCCCCTGTATGCCTCCATGCTGACACAGGCAATGGACTATGACCGGATTCTGGCAGGCTCCCGC
AGCCATCAGACCGGTGTAAACGGTGAAAATAACAGCGTCCGTCTCAGCATTCAGGGCGGTCATCTCGGTCACGATAACAA
CGGCGGTATTGCCCGTGGGGCCACGCCGGAAAGCAGCGGCAGCTATGGCTTCGTCCGTCTGGAGAGTGACCTGCTGAGAA
CAGAGGTTGCCGGTATGTCTGTGACCGCGGGGGTATATAGTGCTGCTGGCCATTCTTCCGTTGATGTTAAGGATGATGAC
GGCTCCCGCGCCGGCACGGTCCGGGATGATGCCGGCAGCCTGGGCGGATACCTGAATCTGGTACACACGTCCTCCGGCCT
GTGGGCTGACATTATGGCACAGGGAACCCGCCACAGCATGAAAGCGTCATCGGACAATAACGACTTCCGCGCCCGGGGCT
GGGGCTGGCTGGGCTCACTGGAAACCGGTCTGCCCTTCAGTATCACTGACAACCTGATGCTGGAACCACAACTGCAGTAC
ACCTGGCAGGGACTTTCCCTGGATGACGGCCAGGATAACGCCGGTTATGTGAAGTTCGGGCATGGCAGTGCACAACATAT
GCGTGCCGGCTTCCGTCTGGGCAGCCACAACGATATGAGCTTTGGTGAAGGCACCTCATCCCGTGACACCCTGCGCGACA
GTGCAAAACACCGTGTGCGTGAACTGCCGGTGAACTGGTGGGTACAGCCTTCTGTTATCCGCACCTTCAGTTCCCGGGGT
GACATGAGCATGGGGACAGCCGCCGCCGGCAGTAACATGACGTTCTCACCGTCCCAGAATGGCACGTCACTGGACCTGCA
GGCCGGACTGGAAGCCCGTGTCCGGGAAAATATCACCCTGGGCGTTCAGGCCGGTTATGCCCACAGCGTCAGCGGCAGCA
GCGCCGAAGGCTATAACGGTCAGGCCACGCTGAATGTGACTTTCTGA

Protein sequence :
MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTPVPALAADTVVEAGETVNGGTLTNHDNQIVFGTT
NGMTISTGLEYGTDNEANTGGQWVQDGGTASNTTISSGGLQFVGAGGKATDTIINEGGGQSLKGLALNTTLNGGEQWMHE
GAIATGTVINDKGWQVVKPGAVATDTVVNTGAEGGPDAENGDTGQFVRGNAVRTTINKNGRQIVTVEGTANTTVVYAGGD
QTVHGHALDTTLNGGNQYVHNGGTTSDTVVNSDGWQIIKEGGLADFTTVNQKGKLQVNAGGTATNVTLKQGGALVTSTAA
TVTGSNRLGNFAVENGKADGVVLESGGRLDVLEGHSAQKTRVDDGGTLAVSAGGKATGVTMTSGGALIADSGATVEGTNA
SGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE
IRFDNQTTQDAVLSRAVAKGDAPVTFHKLTTSNLTGQGGTINMRVRLDGSNASDQLVINGGQATGKTWLAFTNVGNSNLG
VATSGQGIRVVDAQNGATTEEGAFALSRPLQAGAFNYTLNRDSDEDWYLRSENAYRAEVPLYASMLTQAMDYDRILAGSR
SHQTGVNGENNSVRLSIQGGHLGHDNNGGIARGATPESSGSYGFVRLESDLLRTEVAGMSVTAGVYSAAGHSSVDVKDDD
GSRAGTVRDDAGSLGGYLNLVHTSSGLWADIMAQGTRHSMKASSDNNDFRARGWGWLGSLETGLPFSITDNLMLEPQLQY
TWQGLSLDDGQDNAGYVKFGHGSAQHMRAGFRLGSHNDMSFGEGTSSRDTLRDSAKHRVRELPVNWWVQPSVIRTFSSRG
DMSMGTAAAGSNMTFSPSQNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSSAEGYNGQATLNVTF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AAL08472.1 putative autotransporter Not tested SRL Protein 0.0 94
unnamed CAE85197.1 antigen43 protein orthologue Not tested PAI V 536 Protein 0.0 94
Z1211 NP_286746.1 adhesin Not tested TAI Protein 0.0 88
Z1651 NP_287154.1 adhesin Not tested TAI Protein 0.0 88
S3195 NP_838479.1 outer membrane fluffing protein Not tested SHI-1 Protein 0.0 66
aec67 AAW51750.1 Aec67 Not tested AGI-3 Protein 0.0 66
aidA ADD91708.1 AidA Not tested PAI-I AL862 Protein 0.0 60
unnamed CAD66200.1 hypothetical protein Virulence PAI III 536 Protein 0.0 59
sap AAK00474.1 Sap Not tested SHI-1 Protein 0.0 59
SF2991 NP_708765.1 outer membrane fluffing protein Not tested SHI-1 Protein 0.0 59
flu CAI43838.1 antigen 43 Not tested LEE Protein 0.0 58

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
flu1 YP_001744298.1 antigen 43 VFG1063 Protein 0.0 94
flu1 YP_001744298.1 antigen 43 VFG1675 Protein 0.0 59
flu1 YP_001744298.1 antigen 43 VFG0655 Protein 0.0 59