Gene Information

Name : dhfrV (EcSMS35_A0121)
Accession : YP_001740004.1
Strain :
Genome accession: NC_010488
Putative virulence/resistance : Resistance
Product : dihydrofolate reductase type 5
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0262
EC number : 1.5.1.3
Position : 91389 - 91871 bp
Length : 483 bp
Strand : +
Note : identified by similarity to SP:P11731; match to protein family HMM PF00186

DNA sequence :
ATGAGAACCTTGAAAGTATCATTGATGGCTGCGAAAGCGAAAAACGGCGTGATTGGTTGCGGTCCAGACATACCCTGGTC
CGCGAAAGGGGAGCAGCTACTTTTTAAAGCATTGACCTACAATCAGTGGCTTCTGGTGGGTCGCAAGACGTTTGAATCTA
TGGGCGCACTCCCCAATAGGAAATACGCGGTCGTTACCCGCTCAGGTTGGACATCAAATGATGACAATGTAGTTGTATTT
CAGTCAATCGAAGAGGCCATGGACAGGCTAGCTGAATTCACCGGTCACGTTATAGTGTCTGGTGGCGGAGAAATTTACCG
AGAAACATTACCCATGGCCTCTACGCTCCACTTATCGACGATCGACATCGAGCCAGAGGGGGATGTTTTCTTCCCGAGTA
TTCCAAATACCTTCGAAGTTGTTTTTGAGCAACACTTTACTTCAAACATTAACTATTGCTATCAAATTTGGAAAAAGGGT
TAA

Protein sequence :
MRTLKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRSGWTSNDDNVVVF
QSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDIEPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dfrA5 AFG30110.1 dihydrofolate reductase Not tested PAGI-2 Protein 6e-63 91
dfrA5 AET25387.1 dihydrofolate reductase Not tested PAGI-2(C) Protein 6e-63 91
dfrA1 ADZ05803.1 trimethoprim-insensitive dihydrofolate reductase Not tested AbaR3 Protein 4e-65 90
unnamed AEL12695.1 DfrA5 Not tested AbaR21 Protein 4e-65 90
dfrA15 AGK07099.1 DfrA15 dihydrofolate reductase Not tested SGI1 Protein 6e-55 75
dfrA1 AAX48777.1 DfrA1 trimethoprim-insensitive dihydrofolate reductase Not tested SGI2 Protein 1e-53 72
dfrI CAJ77029.1 dihydrofolate reductase type I Not tested AbaR1 Protein 1e-53 72
dfrA1 AGF34987.1 DfrA1 dihydrofolate reductase Not tested SGI1 Protein 1e-53 72