Gene Information

Name : YPK_3906 (YPK_3906)
Accession : YP_001722624.1
Strain : Yersinia pseudotuberculosis YPIII
Genome accession: NC_010465
Putative virulence/resistance : Virulence
Product : type III secretion system ATPase
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : 3.6.3.15
Position : 4305085 - 4306422 bp
Length : 1338 bp
Strand : -
Note : KEGG: ypi:YpsIP31758_3818 type III secretion apparatus H+-transporting two-sector ATPase; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit doma

DNA sequence :
ATGAAACTGCCTGATATCGCGCGGTTAACCCCCCGCCTGCAACAACAACTCACGCGACCGTCGGCACCACCGGAGGGCTT
GCGTTACCGTGGGCCGATTGTGGAGATTGGGCCGACCTTGTTACGAGCCAGCCTACCCAATGTGGCGCAGGGTGAATTAT
GCCGCATTGAACCGCAAGGGATGTTAGCTGAAGTGGTATCGATTGAGCAGGAAATGGCCTTGTTATCCCCCTTTGCCTCT
TCAGATGGCCTGCGTTGTGGGCAATGGGTGACGCCACTTGGACACATGCACCGGGTACAGGTGGGGGCTGATTTGGCCGG
GCGGATCTTGGATGGCCTAGGTGCTCCGATAGACGGCGGCCCCCCGCTGACGGGGCAGTGGCGTGAACTGGATTGCCCCC
CGCCTAGCCCATTAACCCGCCAGCCGGTAGAGCAAATGTTGACCACCGGGGGCCGCGCGATTGATGGGATATTGAGCTGT
GGCGAGGGCCAGCGTATTGGTATTTTTGCCGCCGCTGGCGTTGGGAAAAGTACTTTATTGAGCATGTTATGTGCTGATAG
TGCGGCCGATGTGATGGTGCTAGCACTGATTGGTGAGCGTGGGCGGGAGGTGCGCGAATTTCTTGAACAGGTGCTGACTC
CGGAGGCGCGTGCGCGCACCGTGGTGGTGGTGGCGACCTCTGACCGGCCAGCATTGGAGCGGTTGAAGGGGCTGTCTACT
GCCACCACGGTGGCGGAGTATTTTCGCGAACGTGGATTGAAGGTGTTGTTACTGGCGGATTCACTGACCCGCTATGCCCG
TGCCGCCCGTGAAATTGGTCTGGCGGCAGGTGAGCCACCGGCTGCTGGCAGTTTCCCCCCAAGTGTTTTTGCCAACTTAC
CCCGTCTGTTGGAGCGAACGGGTAACAGTGATCGCGGCAGCATTACGGCTTTTTATACCGTGCTGGTGGAGGGAGATGAC
ATGAATGAACCGGTAGCCGATGAAGTGCGTTCGCTGTTGGATGGGCACATCGTTTTATCACGACGGTTGGCCGGTGCTGG
GCATTATCCGGCGATTGATATTGCCGCCAGCGTCAGCCGTATCATGCCGCAAATCGTCAGTGCCGGGCAGTTGGCGATGG
CACAAAAACTACGGCGAATGCTGGCCTGTTATCAGGAGATCGAGCTGTTGGTGCAGATTGGTGAATATCAGGCAGGAGAA
GACCTACAGGCTGATGAAGCCTTACAACGCTATCCGGCAATATGCGCCTTTTTACAACAAGACCACAGCCTAACGCGTGA
CCCAGATACTGCTCATCTTGATACCACTCTGGAACACCTGGCGCAGGTTGTCGGTTGA

Protein sequence :
MKLPDIARLTPRLQQQLTRPSAPPEGLRYRGPIVEIGPTLLRASLPNVAQGELCRIEPQGMLAEVVSIEQEMALLSPFAS
SDGLRCGQWVTPLGHMHRVQVGADLAGRILDGLGAPIDGGPPLTGQWRELDCPPPSPLTRQPVEQMLTTGGRAIDGILSC
GEGQRIGIFAAAGVGKSTLLSMLCADSAADVMVLALIGERGREVREFLEQVLTPEARARTVVVVATSDRPALERLKGLST
ATTVAEYFRERGLKVLLLADSLTRYARAAREIGLAAGEPPAAGSFPPSVFANLPRLLERTGNSDRGSITAFYTVLVEGDD
MNEPVADEVRSLLDGHIVLSRRLAGAGHYPAIDIAASVSRIMPQIVSAGQLAMAQKLRRMLACYQEIELLVQIGEYQAGE
DLQADEALQRYPAICAFLQQDHSLTRDPDTAHLDTTLEHLAQVVG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 0.0 99
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-111 59
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 7e-111 59
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 5e-111 59
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 3e-111 59
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 3e-111 59
lscN AAO18044.1 LscN Virulence TTSS locus Protein 2e-98 56
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 8e-95 52
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 8e-95 52
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 6e-98 52
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 6e-98 52
unnamed AAL06369.1 EscN Virulence LEE Protein 3e-98 52
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-93 51
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 1e-93 51
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 7e-95 50
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 3e-95 50
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 3e-95 50
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-94 50
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 4e-95 50
escN AAL57542.1 EscN Virulence LEE Protein 2e-100 50
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 8e-101 50
escN CAC81862.1 EscN protein Virulence LEE II Protein 7e-101 50
escN YP_003223475.1 translocator EscN Virulence LEE Protein 5e-101 50
escN CAI43874.1 EscN protein Virulence LEE Protein 3e-101 50
escN AAK26715.1 EscN Virulence LEE Protein 2e-100 50
escN AAC38383.1 EscN Virulence LEE Protein 1e-100 50
escN NP_290268.1 hypothetical protein Virulence LEE Protein 2e-100 50
escN AAC31513.1 L0034 Virulence LEE Protein 2e-100 50
ECs4568 NP_312595.1 EscN Virulence LEE Protein 2e-100 50
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 2e-100 50
escN YP_003236088.1 translocator EscN Virulence LEE Protein 2e-100 50
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 5e-75 49
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 2e-82 49
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 1e-74 48
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 1e-74 48
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 1e-75 48
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 4e-77 48
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 2e-78 48
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 4e-79 48
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 7e-77 47
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 9e-76 47
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 2e-75 47
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 5e-78 47
invC AAS66861.1 InvC Not tested SSR-2 Protein 1e-69 47
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-70 45
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-70 45
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-70 45
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 1e-70 45
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 7e-68 43
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 6e-68 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG0515 Protein 3e-111 59
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG0192 Protein 2e-98 57
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG0390 Protein 4e-97 56
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG2331 Protein 1e-75 53
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG0048 Protein 6e-96 52
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG0730 Protein 8e-101 50
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG0812 Protein 1e-100 50
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG2144 Protein 2e-83 50
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG1254 Protein 4e-83 50
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG2499 Protein 3e-76 50
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG1778 Protein 2e-69 47
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG2459 Protein 5e-74 45
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG0555 Protein 6e-71 45
YPK_3906 YP_001722624.1 type III secretion system ATPase VFG1008 Protein 5e-68 44