Gene Information

Name : ureC (ABAYE2776)
Accession : YP_001714582.1
Strain : Acinetobacter baumannii AYE
Genome accession: NC_010410
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 2794396 - 2796096 bp
Length : 1701 bp
Strand : -
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGAAAATGTCACGTCGTGCATACGCAGAAATGTTTGGTCCAACGGTTGGTGATCGTATTCGTTTGGCTGATACAGCGCT
TTTTATTGAAGTTGAGCAAGACTTAACGACATATGGTGAAGAAGTTAAATTTGGTGGCGGAAAAGTTATTCGTGACGGGA
TGGGACAATCTCAGCTTCTAGCTGATGAAGTTGCCGATACAGTCATAACCAATGCTTTAATTGTGGATTGGTGGGGAATT
GTTAAAGCCGATGTGGGCTTAAAGAATGGACGAATCTGGAAAATTGGGAAAGCTGGAAACCCTGATATTCAACCCGACAT
TACCATTCCTTTAGGTGCTGCGACAGAAGTAATTGCAGGTGAAGGACAAATTTTAACAGCTGGTGGTATTGATACTCATA
TTCACTGGATCTGTCCTCAGCAAGTTGAAACCGCGCTGATGTCTGGGACAACGACAATGGTGGGGGGTGGGACAGGACCT
GCGGCAGGTACTTCGGCAACGACTGTGACTCCAGGGCCTTGGCATATTGCGACCATGTTGCAGGCGATTGATGATTTGCC
TATGAATATTGGTCTATTGGGTAAAGGGAATTTAAGTTTACCTGACCCCATTAGCGAGCAAATTAAAGCAGGAGTAATTG
GGTTAAAACTACACGAAGATTGGGGTTCAACACCTGCGGCTATTGATAACTGTTTGAGCGTTGCAGATGAGTATGATGTA
CAGGTCGCAATTCATACGGATACATTGAATGAAGGTGGTTTTTTAGAAGAAACGCTAGCGGCATTTAAAGACCGTACGAT
TCATACGTATCATACCGAAGGTGCGGGCGGCGGGCATGCTCCCGATATTTTAAAAGCAATTGGGCAAAGTAATGTCTTGC
CATCTTCGACCAACCCAACACGACCTTACACGATCAATACCATTGATGAGCATTTAGATATGCTCATGGTATGCCACCAT
TTAGACCCAGCAATTGCTGAAGATATTGCTTTTGCAGAAAGTCGTATTCGTCGTGAAACCATTGCTGCTGAAGATATTTT
ACAAGACTTAGGCGCAATTGCCATGATGTCATCTGACTCTCAGGCAATGGGACGTGTGGGTGAAGTGATTTTACGAACTT
GGCAAACTGCCCACAAAATGAAAGTACAACGTGGCCCATTAGAGGGTGATAATGAGTTTCATGATAACAATCGCGTTAAA
CGCTACATTGCCAAATATACAATTAACCCGGCAATTACCCATGGTTTAAGCCATGAAATTGGTTCGGTTGAAGTCGGAAA
ACTTGCTGATTTAGTGTTATGGAAGCCTGCGTTTTTTGGCGTGAAACCTTCCATGATCATTAAAGGTGGCATGATTGCAG
CAGCGCCGATGGGTGATATTAATGCCTCTATTCCGACACCTCAACCCGTGCATTATCGTCCAATGTTTGGGGCTTATCCG
CGTGGTGTACATAACACCTGTATAACCTTTTTATCTCAAGTCGCAATTGATGAAAAAGTTGCTGAGAAGCTAAACCTTAA
AAAGTTAATCAGTCCCTGTAAAAACACGCGTTCAATTACCAAAGCCGATATGAAACACAATACATATTGTCCTGTTATGC
AGGTTCATCCTGAGACTTACGAGGTGCGGGCCGATGGTGAATTATTAACGTGTGAACCTGCTGACGTATTACCGATGGCA
CAACGTTATTTCTTGTTTTAA

Protein sequence :
MKMSRRAYAEMFGPTVGDRIRLADTALFIEVEQDLTTYGEEVKFGGGKVIRDGMGQSQLLADEVADTVITNALIVDWWGI
VKADVGLKNGRIWKIGKAGNPDIQPDITIPLGAATEVIAGEGQILTAGGIDTHIHWICPQQVETALMSGTTTMVGGGTGP
AAGTSATTVTPGPWHIATMLQAIDDLPMNIGLLGKGNLSLPDPISEQIKAGVIGLKLHEDWGSTPAAIDNCLSVADEYDV
QVAIHTDTLNEGGFLEETLAAFKDRTIHTYHTEGAGGGHAPDILKAIGQSNVLPSSTNPTRPYTINTIDEHLDMLMVCHH
LDPAIAEDIAFAESRIRRETIAAEDILQDLGAIAMMSSDSQAMGRVGEVILRTWQTAHKMKVQRGPLEGDNEFHDNNRVK
RYIAKYTINPAITHGLSHEIGSVEVGKLADLVLWKPAFFGVKPSMIIKGGMIAAAPMGDINASIPTPQPVHYRPMFGAYP
RGVHNTCITFLSQVAIDEKVAEKLNLKKLISPCKNTRSITKADMKHNTYCPVMQVHPETYEVRADGELLTCEPADVLPMA
QRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 0.0 73
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 0.0 73
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-167 65
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-167 65
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 4e-167 65
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-167 65

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_001714582.1 urease subunit alpha VFG0270 Protein 1e-145 60