Gene Information

Name : MAB_2247c (MAB_2247c)
Accession : YP_001702982.1
Strain : Mycobacterium abscessus ATCC 19977
Genome accession: NC_010397
Putative virulence/resistance : Virulence
Product : Bifunctional enzyme MbtA : salicyl-AMP ligase + salicyl-S-ArCP synthetase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 2274357 - 2276009 bp
Length : 1653 bp
Strand : -
Note : Similar to P71716_MYCTU 0.0

DNA sequence :
ATGACTCAGCCCAGATCGACCACCACCGCGTCGTCAGCCGCAACCCCCGCACTGGATGGTTTCGTCCCGTTTCCCTCGGT
ACGCGCCGACGAATATCGCCGGGCCGGGTACTGGACGGGCAACACCGTCGAATCGCTGCTTCGCGTGTCCGCGGCCAGGC
GGCCATGCCATCCGGCTGTGATCGACGAACACCGCGCGCTGAGCTATCGAGAACTGGACGAGGCAGCCGACAATGCCGCA
CACGCCTTCCTCCGGCTGGGGATAGCGCCCGGCGATCGGGTGCTGCTCCAACTCCCCAATCGGGCATCGTTTGCCGTCGC
GCTATTCGGCTTGATGCGTGCCGGCGCAATACCCGTGATGTGCCTTCCCGGGCACCGGGCCGCCGAACTGTCCCACTTCA
TCGAGGTGGCCGACGCTGTCGGATTGGTTATCCCCGATTCGGCCGGTGGATTCGATTACCGCGCGCTGGCGGTCGCGCTG
TCCCAGCGGCATCCGCGCCTGCGCACGGTGGTCGTGGAGGGTGATGCGGGCCCCTTCGCATCCTGGACGTCGCTGCTGAA
AAGTGTTGAGCCGCAGGGTCCGCTACCTACCGTGCAGACGGACACTCCTGCCCTACTGCTGGTGTCCGGCGGCACCACCG
CAGCACCCAAGCTGATCCCTCGCACCCACGAGGACTACGTCTACAACGCCACACAGGCAGCACGGGTCTGCGGTCTGACC
CAGGACGACGTTTACCTCGTGGCACTGCCCGCCGGCCATAATTTCCCCCTGGCTTGCCCGGGCTTGCTTGGTGCGATAAG
CACCGGTGCGACCACGGTTTTCCTCTCGGATCCGAGTCCGGAGTCGGCTTTCGCGACCATCGCTCGCCATCGAGTGTCGG
TGACGGCAGTGGTGCCATCGCTTGCACAGCTATGGGCTCAAGCCACCGCGTGGGAGCCGGTGCTGCCGGAAACACTGAGG
CTGCTCCAGGTTGGTGGCGCCAAACTCGGCGCCGACGACGCACGAGCGGTACGAGAGTCGCTCACCCAGGGACTGCAACA
GGTTTTCGGCATGGCAGAGGGCCTGTTATGCCTCACACAGCCAGGCGATCCCACCGATATCCTGGATAACAGCCAGGGCC
GTCCCATGTGCGACGCGGACGAGGTGCGCATAGTCGACGAGGACGGCGCCGACGTCCCCGCCGGAGAAACCGGGGAACTG
CTCGTGCGTGGGCCATACACCCTCAACGGGTACTACCGCGCCGACGCCGACAACATGCGCTCGTTCACTGTCGACGGTTT
CTATCGCAGCGGTGACCGGGTACGCGCACTACCGGGCGGTTATCTGGAAGTCACCGGACGCATCAAGGATGTCATTCTCC
GTGGCGGGGAATCCATCGCCGCGTTGGATCTCGAATCGCACTTGCAGACCCATCCGGCGGTCTACGCCGCAGCGGCGGTG
GGCCTTCCCGATCAGTATCTTGGCGAGATTGTCTGTGCTGCAATTGTTTTCAAGGGAAAACCGGTCGCCGCCGCCGAACT
CAATCAGCATCTGCAAGCCCGTGGCGCCGCGACCCATTCACGCGTCGACAAACTGGTCGCCGTTTCCGCACTGCCACTGA
CCGCTGTGGGCAAGATCGACAAGCGAGCGCTGCTGGCCTCCCTGACGGGCTAG

Protein sequence :
MTQPRSTTTASSAATPALDGFVPFPSVRADEYRRAGYWTGNTVESLLRVSAARRPCHPAVIDEHRALSYRELDEAADNAA
HAFLRLGIAPGDRVLLQLPNRASFAVALFGLMRAGAIPVMCLPGHRAAELSHFIEVADAVGLVIPDSAGGFDYRALAVAL
SQRHPRLRTVVVEGDAGPFASWTSLLKSVEPQGPLPTVQTDTPALLLVSGGTTAAPKLIPRTHEDYVYNATQAARVCGLT
QDDVYLVALPAGHNFPLACPGLLGAISTGATTVFLSDPSPESAFATIARHRVSVTAVVPSLAQLWAQATAWEPVLPETLR
LLQVGGAKLGADDARAVRESLTQGLQQVFGMAEGLLCLTQPGDPTDILDNSQGRPMCDADEVRIVDEDGADVPAGETGEL
LVRGPYTLNGYYRADADNMRSFTVDGFYRSGDRVRALPGGYLEVTGRIKDVILRGGESIAALDLESHLQTHPAVYAAAAV
GLPDQYLGEIVCAAIVFKGKPVAAAELNQHLQARGAATHSRVDKLVAVSALPLTAVGKIDKRALLASLTG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 5e-98 45
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-98 45
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 7e-98 45
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-98 45
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-98 45
ybtE CAA21394.1 - Virulence HPI Protein 7e-98 45
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 6e-98 45
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-96 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 9e-97 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MAB_2247c YP_001702982.1 Bifunctional enzyme MbtA : salicyl-AMP ligase + salicyl-S-ArCP synthetase VFG1817 Protein 3e-163 63
MAB_2247c YP_001702982.1 Bifunctional enzyme MbtA : salicyl-AMP ligase + salicyl-S-ArCP synthetase VFG0168 Protein 3e-90 42
MAB_2247c YP_001702982.1 Bifunctional enzyme MbtA : salicyl-AMP ligase + salicyl-S-ArCP synthetase VFG0932 Protein 1e-83 41