Gene Information

Name : thyA (Bsph_2692)
Accession : YP_001698362.1
Strain : Lysinibacillus sphaericus C3-41
Genome accession: NC_010382
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2666028 - 2667005 bp
Length : 978 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGACGCATCCAGAAATGGCGTACTTAAATTTACTACAACATATATTAGAAAATGGCACGAAAAAAGAGGATCGAACTGG
GACGGGGACATATAGCGTCTTTGGTTATCAAATGCGTTTTGATTTAAGCAAAGGGTTTCCACTTTTAACGACAAAGCGCG
TACCTTTTAAGCTTGTCGCGAGCGAATTGTTATGGTTCATTAAAGGGGATACGAATATCCGTTATCTATTGCAACATAAT
AATCATATTTGGGATGAATGGGCATTTAAAAGATGGGTGGAATCAGATGATTATACTGGCCCGGATATGACCGATTTTGG
TCGACGTTGTTTAGTCGATGACGCATTTAATACCATGTACCAACAAGAGTTAGCCTCTTTTTGTGAGCGTGTTTTAGCCG
ATGATGATTTTGCTCAAAAATATGGAGAGCTTGGTAATGTCTATGGCAAGCAATGGCGTCATTGGTCAACTTCTACTGGG
GAAAGTATCGACCAGTTACAGGATGTCATTCATCAAATAAAGCATAATCCAGATTCACGTCGGATTATTGTCAATGCGTG
GAACCCTGAGGATGTAATCAATGCAGGTGCGAAGGGCAGTAAAGCCGCATTGCCACCATGTCATGTTATGTTCCAATTTT
ATGTATCTAATGGCAAATTAAGCTGTCAGCTTATGCAAAGAAGCTTAGACACTTTATTAGGCTGTCCTTTTAATATAGCT
TCTTACGCATTGTTAACTCATTTAATTGCACATGAGTGTGGATTAGAGGTGGGTGAATTTATTCATAGCATTGGGGATGC
TCATATTTATGCGAACCATGTAGAACAAGTAAAAGAACAGCTTGCTCGGGAGCCAAAGGACCTACCGACATTACACATCA
ATCCAAATAAAACTTCGATTTTTGATATCGAGCTTGAGGATTTATCAATCGAGGGCTATGACCCACATCCCGCTATTAAA
GCGCCGATTGCCGTCTAA

Protein sequence :
MTHPEMAYLNLLQHILENGTKKEDRTGTGTYSVFGYQMRFDLSKGFPLLTTKRVPFKLVASELLWFIKGDTNIRYLLQHN
NHIWDEWAFKRWVESDDYTGPDMTDFGRRCLVDDAFNTMYQQELASFCERVLADDDFAQKYGELGNVYGKQWRHWSTSTG
ESIDQLQDVIHQIKHNPDSRRIIVNAWNPEDVINAGAKGSKAALPPCHVMFQFYVSNGKLSCQLMQRSLDTLLGCPFNIA
SYALLTHLIAHECGLEVGEFIHSIGDAHIYANHVEQVKEQLAREPKDLPTLHINPNKTSIFDIELEDLSIEGYDPHPAIK
APIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 1e-98 64