Gene Information

Name : SPH_0449 (SPH_0449)
Accession : YP_001693859.1
Strain : Streptococcus pneumoniae Hungary19A-6
Genome accession: NC_010380
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease ATP-binding subunit ClpL
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 397277 - 399382 bp
Length : 2106 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGAATAACAACTTTAATAATTTTAACAACATGGATGATTTATTTAACCAATTGATGGGTGGTATGCGAGGATACAGTTC
TGAAAATCGCCGTTACTTGATTAATGGACGTGAAGTGACACCTGAGGAATTTGCTCACTATCGTGCAACTGGCCAATTGC
CAGGAAATGCAGAAGTTGATGGAAAAATGCCACAACAGGCTTCAAGTATGAAACAAGACGGTGTTCTTGCTAAACTAGGT
CGTAACCTGACAGCAGAAGCACGTGAGGGCAAGCTGGATCCTGTTATCGGACGAAACAAGGAAATTCAAGAAACATCTGA
AATTCTTTCACGCCGTACCAAGAACAATCCTGTTTTAGTCGGAGACGCTGGCGTTGGTAAGACAGCCGTTGTCGAAGGTC
TAGCACAAGCCATTGTGAACGGTGATGTTCCAGCTGCCATTAAGAATAAGGAAATTATTTCCATTGATATCTCTGGTCTT
GAGGCTGGGACTCAATACCGTGGTAGCTTTGAAGAAAACGTTCAAAACTTAGTCAATGAAGTAAAAGAAGCGGGAAATAT
CATTCTCTTCTTTGATGAAATTCATCAAATTCTCGGTGCTGGTAGCACTGGTGGAGATAGTGGATCTAAGGGACTTGCAG
ACATTCTTAAACCAGCTCTATCTCGTGGAGAATTGACAGTGATTGGGGCAACAACTCAAGACGAATACCGTAACACCATC
TTGAAGAATGCTGCTCTTGCTCGTCGTTTCAACGAAGTGAAGGTCAATGCTCCTTCGGCAGAGAATACTTTTAAAATTCT
TCAAGGAATTCGTGACCTCTATCAACAACACCACAATGTCATCTTGCCAGACGAAGTCTTGAAAGCAGCGGTGGATTATT
CTGTTCAATACATTCCTCAACGTAGCTTGCCAGATAAGGCTATTGACCTTGTCGATGTAACGGCTGCTCACTTGGCGGCT
CAACATCCAGTAACAGATGTGCATGCTGTTGAACGAGAAATCGAAACGGAAAAAGACAAGCAAGAAAAAGCAGTTGAAGC
AGAAGATTTTGAAGCAGCTCTAAACTATAAAACACGCATTGCAGAATTGGAAAAGAAAATCGAAAACCACACAGAAGATA
TGAAAGTGACTGCAAGTGTCAACGATGTGGCTGAATCTGTGGAACGAATGACAGGTATCCCAGTATCGCAAATGGGAGCT
TCAGATATCGAACGTTTGAAAGATATGGCTCATCGCTTGCAAGACAAGGTGATTGGTCAAGATAAGGCCGTAGAAGCTGT
AGCTCGTGCTATCCGTCGTAACCGTGCTGGTTTTGATGAAGGAAATCGCCCAATCGGCAGCTTCCTCTTTGTAGGGTCTA
CTGGGGTTGGTAAGACGGAGCTTGCTAAGCAATTGGCACTCGATATGTTTGGAACCCAGGATGCGATTATCCGTTTGGAT
ATGTCTGAATACAGTGACCGCACAGCTGTTTCTAAGCTAATTGGTACAACAGCAGGCTATGTGGGTTATGATGACAATAG
CAATACCTTAACAGAACGTGTTCGTCGCAATCCATACTCTATCATTCTCTTGGATGAAATTGAAAAGGCTGATCCTCAAG
TTATTACCCTTCTCCTCCAAGTTCTAGATGATGGTCGTTTGACAGATGGTCAAGGAAATACAGTAAACTTCAAGAATACT
GTCGTTATTGCGACCTCAAATGCTGGATTTGGCTATGAAGCCAATTTGACAGAAGATGCGGATAAACCAGAATTGATGGA
CCGTTTGAAACCCTTCTTCCGTCCAGAATTCCTCAACCGCTTTAATGCAGTCATCGAGTTCTCACACTTGACTAAGGAAA
ACCTTTCTAAGATTGTAGATTTGATGTTGGCTGAAGTTAACCAAACCTTGGCTAAGAAAGACATTGACTTGGTAGTCAGT
CAAGCGGCTAAAGATTATATCACAGAAGAAGGTTACGACGAAGTCATGGGGGTTCGTCCTCTCCGTCGCGTGGTTGAACA
AGAAATTCGTGATAAGGTGACAGACTTCCACTTGGATCATTTAGATGCTAAACATCTGGAAGCAGATATGGAAGATGGCG
TTTTGGTTATTCGTGAGAAAGCCTAA

Protein sequence :
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAEVDGKMPQQASSMKQDGVLAKLG
RNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAA
QHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELEKKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGA
SDIERLKDMAHRLQDKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VVIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKENLSKIVDLMLAEVNQTLAKKDIDLVVS
QAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 5e-137 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SPH_0449 YP_001693859.1 ATP-dependent Clp protease ATP-binding subunit ClpL VFG0080 Protein 3e-146 48
SPH_0449 YP_001693859.1 ATP-dependent Clp protease ATP-binding subunit ClpL VFG0079 Protein 4e-142 45