Gene Information

Name : SPH_1420 (SPH_1420)
Accession : YP_001694729.1
Strain : Streptococcus pneumoniae Hungary19A-6
Genome accession: NC_010380
Putative virulence/resistance : Resistance
Product : rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein)
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0030
EC number : 2.1.1.48
Position : 1317862 - 1318599 bp
Length : 738 bp
Strand : -
Note : identified by match to protein family HMM PF00398

DNA sequence : 
ATGAACAAAAATATAAAATATTCTCAAAACTTTTTAACGAGTGAAAAAGTACTCAACCAAATAATAAAACAATTGAATTT
AAAAGAAACCGATACCGTTTACGAAATTGGAACAGGTAAAGGGCATTTAACGACGAAACTGGCTAAAATAAGTAAACAGG
TAACGTCTATTGAATTAGACAGTCATCTATTCAACTTATCGTCAGAAAAATTAAAACTGAATACTCGTGTCACTTTAATT
CACCAAGATATTCTACAGTTTCAATTCCCTAACAAACAGAGGTATAAAATTGTTGGGAATATTCCTTACCATTTAAGCAC
ACAAATTATTAAAAAAGTGGTTTTTGAAAGCCGTGCGTCTGACATCTATCTGATTGTTGAAGAAGGATTCTACAAGCGTA
CCTTGGATATTCACCGAACACTAGGGTTGCTCTTGCACACTCAAGTCTCGATTCAGCAATTGCTTAAGCTGCCAGCGGAA
TGCTTTCATCCTAAACCAAAAGTAAACAGTGTCTTAATAAAACTTACCCGCCATACCACAGATGTTCCAGATAAATATTG
GAAGCTATATACGTACTTTGTTTCAAAATGGGTCAATCGAGAATATCGTCAACTGTTTACTAAAAATCAGTTTCATCAAG
CAATGAAACACGCCAAAGTAAACAATTTAAGTACCATTACTTATGAGCAAGTATTGTCTATTTTTAATAGTTATCTATTA
TTTAACGGGAGGAAATAA

Protein sequence : 
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLI
HQDILQFQFPNKQRYKIVGNIPYHLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAE
CFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLL
FNGRK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ermA BAC57474.1 rRNA methylase Not tested Type-IIIinv SCCmec Protein 6e-54 52
ermA BAA82205.1 rRNA adenine N-6-methyltransferase Not tested Type-II SCCmec Protein 6e-54 52
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 Not tested Type-II SCCmec Protein 8e-54 52
ermA NP_370576.1 rRNA methylase Not tested Type-II SCCmec Protein 8e-54 52
ermA NP_373288.1 rRNA methylase Not tested Type-II SCCmec Protein 8e-54 52
ermA-3 YP_190052.1 rRNA adenine N-6-methyltransferase Not tested Type-II SCCmec Protein 8e-54 52
unnamed BAB47663.1 rRNA adenine N-6-methyltransferase Not tested Type-III SCCmec Protein 1e-53 52
unnamed BAC53825.1 rRNA adenine N-6-methyltransferase Not tested SRImec-III and SCCmec-III region Protein 1e-53 52
ermC NP_273130.1 rRNA adenine N-6-methyltransferase Not tested IHT-A Protein 3e-57 51

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) AM903082.gene3.p01 Protein 9e-112 99
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) AM410044.gene14.p01 Protein 9e-112 99
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) AM180355.1.gene2259. Protein 9e-111 98
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) AM180355.1.gene2254. Protein 9e-111 98
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) M64090.gene.p01 Protein 2e-56 53
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002745.1122822.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002745.1124324.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002745.1125313.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) AJ313523.1.orf0.gene Protein 7e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_009782.5559087.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002758.1121630.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002952.2859615.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002745.1123579.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002745.1124852.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_009782.5559229.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002758.1120012.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_002952.2859614.p0 Protein 4e-54 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) V01278.gene.p01 Protein 2e-58 52
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) M15332.gene.p01 Protein 2e-53 51
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_010685.6295744.p0 Protein 1e-57 51
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_007209.3523503.p0 Protein 1e-57 51
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_007792.3912746.p0 Protein 4e-57 51
SPH_1420 YP_001694729.1 rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) NC_010686.6295746.p0 Protein 1e-57 51