Gene Information

Name : SPH_1266 (SPH_1266)
Accession : YP_001694589.1
Strain : Streptococcus pneumoniae Hungary19A-6
Genome accession: NC_010380
Putative virulence/resistance : Resistance
Product : chloramphenicol O-acetyltransferase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG4845
EC number : 2.3.1.28
Position : 1174416 - 1175066 bp
Length : 651 bp
Strand : +
Note : identified by match to protein family HMM PF00302

DNA sequence : 
ATGAACTTTAATAAAATTGATTTAGACAATTGGAAGAGAAAAGAGATATTTAATCATTATTTGAACCAACAAACGACTTT
TAGTATAACCACAGAAATTGATATTAGTGTTTTATACCGAAACATAAAACAAGAAGGATATAAATTTTACCCTGCATTTA
TTTTCTTAGTGACAAGGGTGATAAACTCAAATACAGCTTTTAGAACTGGTTACAATAGCGACGGAGAGTTAGGTTATTGG
GATAAGTTAGAGCCACTTTATACAATTTTTGATGGTGTATCTAAAACATTCTCTGGTATTTGGACTCCTGTAAAGAATGA
CTTCAAAGAGTTTTATGATTTATACCTTTCTGATGTAGAGAAATATAATGGTTCGGGGAAATTGTTTCCCAAAACACCTA
TACCTGAAAATGCTTTTTCTCTTTCTATTATTCCATGGACTTCATTTACTGGGTTTAACTTAAATATCAATAATAATAGT
AATTACCTTCTACCCATTATTACAGCAGGAAAATTCATTAATAAAGGTAATTCAATATATTTACCGCTATCTTTACAGGT
ACATCATTCTGTTTGTGATGGTTATCATGCAGGATTGTTTATGAACTCTATTCAGGAATTGTCAGATAGGCCTAATGACT
GGCTTTTATAA

Protein sequence : 
MNFNKIDLDNWKRKEIFNHYLNQQTTFSITTEIDISVLYRNIKQEGYKFYPAFIFLVTRVINSNTAFRTGYNSDGELGYW
DKLEPLYTIFDGVSKTFSGIWTPVKNDFKEFYDLYLSDVEKYNGSGKLFPKTPIPENAFSLSIIPWTSFTGFNLNINNNS
NYLLPIITAGKFINKGNSIYLPLSLQVHHSVCDGYHAGLFMNSIQELSDRPNDWLL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
catA2 ACF06176.1 chloramphenicol acetyltransferase II Not tested Tn5036-like Protein 1e-36 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SPH_1266 YP_001694589.1 chloramphenicol O-acetyltransferase NC_010427.6155852.p0 Protein 3e-88 100
SPH_1266 YP_001694589.1 chloramphenicol O-acetyltransferase NC_010426.6155849.p0 Protein 3e-88 100
SPH_1266 YP_001694589.1 chloramphenicol O-acetyltransferase NC_010111.5787932.p0 Protein 1e-53 55
SPH_1266 YP_001694589.1 chloramphenicol O-acetyltransferase CP001581.1.gene2168. Protein 5e-41 43
SPH_1266 YP_001694589.1 chloramphenicol O-acetyltransferase CP004022.1.gene799.p Protein 6e-37 42