Gene Information

Name : metB (APJL_0679)
Accession : YP_001651692.1
Strain : Actinobacillus pleuropneumoniae JL03
Genome accession: NC_010278
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : -
Position : 743947 - 745083 bp
Length : 1137 bp
Strand : -
Note : catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity

DNA sequence :
ATGACCAAATACAGTAACATTGAAACCACATTAGTACAGTTAGGCAACCGCACCGACCCTAGAACGGGAGCGGTAGCCAC
ACCGATTGTTTTATCGACCGCTTATGGTCGTGACGGTTTGGGCGAATCGACCGGTTGGGATTATATTCGTACCAAAAACC
CGACCCGTGCCGTGTTAGAGCAAGGTATTGCTGATTTCGAGGGGGGAGATGCCGGTTTTGCAATGGCATCGGGTATGGCG
GCAATTCAGTTAGTGATGTCATTGTTTAAAGCGCCTGATGAGTGGATTATTTCAAGTGATGTATATGGCGGCTCTTACCG
TTTATTCGATTTCAGTCATAAACACCACAATACAGTAAAACCGGTTTATGTAAATACCGCAGATTTGGCGGCGATTGAAG
CGGCAATTACCCCAAACACTAAAGCGATTTTTGTTGAAACACCGTCAAACCCATTAATGGAAGAGTGTGATGTTGATGCA
ATTTCTAAAATTGCGAAAAAACATAACTTAATGTTAATTGTGGATAATACCTTCTTAACGCCGATTTTATTCCGTCCGAT
TGAACACGGTGCGGATATCGTGATTCACAGTGCAACGAAATACCTTTCCGGTCATAATGATGTGTTAGCCGGTTTAATCG
TTGCGAAAGATTCGGAAGCAACCAAAAACGAAGCGGGTCAAAAGCTTTCGGAACGTTTATTCTACTTCCAAAACTGTGCC
GGTGCGGTGCTTTCGCCGTTTGATTCTTACCTTGCGGTGCGTGGCTTAAAAACCCTTGCGTTACGTATGGAACGCCACCA
ATCGAATGCTACGGAATTAGCGAGATTCTTAAGCGAGCAACCGGAGATTGAGAGCGTACTTTATTCAGGTAAGAGCGGTA
TGCTTTCATTCCGTTTACAAAAAGAAGAGTGGGTACCGAAATTCTTAAAAGCGATTAAGTTGATTACCTTTGCGGAAAGT
TTAGGCGGTACGGAAAGTTTTATCACTTATCCGTCCACTCAAACACATATGGATATTCCGGAAGCGGAGCGTATTGCACG
TGGTATCACCAATAACTTACTGCGTTTCTCAGTTGGCTTGGAACATGTTGAAGATTTAAAAGCGGATTTACGCCAAGCGT
TCGGACAACTAAAATAA

Protein sequence :
MTKYSNIETTLVQLGNRTDPRTGAVATPIVLSTAYGRDGLGESTGWDYIRTKNPTRAVLEQGIADFEGGDAGFAMASGMA
AIQLVMSLFKAPDEWIISSDVYGGSYRLFDFSHKHHNTVKPVYVNTADLAAIEAAITPNTKAIFVETPSNPLMEECDVDA
ISKIAKKHNLMLIVDNTFLTPILFRPIEHGADIVIHSATKYLSGHNDVLAGLIVAKDSEATKNEAGQKLSERLFYFQNCA
GAVLSPFDSYLAVRGLKTLALRMERHQSNATELARFLSEQPEIESVLYSGKSGMLSFRLQKEEWVPKFLKAIKLITFAES
LGGTESFITYPSTQTHMDIPEAERIARGITNNLLRFSVGLEHVEDLKADLRQAFGQLK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-63 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-64 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_001651692.1 cystathionine gamma-synthase BAC0207 Protein 5e-51 42