Gene Information

Name : Mext_4349 (Mext_4349)
Accession : YP_001641789.1
Strain : Methylobacterium extorquens PA1
Genome accession: NC_010172
Putative virulence/resistance : Resistance
Product : NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1052
EC number : -
Position : 4838371 - 4839381 bp
Length : 1011 bp
Strand : +
Note : PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: rpc:RPC_4634 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

DNA sequence :
ATGGACGTCACGATCTTCAGCACCAAGGCCTATGATCGGCGGTTCCTGGACGAGGCCAACGCGGCGGCGGGAGAGCCGCA
CCGGCTGCGCTATCTCGAAGCCCGGTTGACCCATGAGAGTGCGCCGCTGACGCAGGGAGCGCGAGCCGTGTGCGCCTTCG
TCAACGACGTGCTCGACCGGCCCGTTCTGGGGGTGCTGGCCGCCTCCGGCACGCGGATGGTGGCCCTGCGCAGCGCCGGC
TTCAACAATGTCGATCTTCCCGCCGCTGTGGAACTCGGCATCGCGGTCGGCCGCGTCCCGGCCTACTCGCCGGACGCGGT
CGCCGAGCATACGGTGGCCCTGATCCTCGCGCTCAATCGCAAGACCCACCGGGCCTATGCCCGCGTCCGCGAGGGAAACT
TCGCGCTCGAGGGGTTGCTGGGCTTCGATCTCAAGGGCCGCACAGTCGGCATCGTCGGAACCGGCAAGATCGGTCGCGCG
GTCGCGCGCATCCTCGCCGGCTTCGGCTGCCGCGTGCTGGCTTATGATCCCGTGCCCTCGGCCGAACTCGCCGGCTTCGG
CGCGGAGGCGGCGGGCCTCGACCGGCTTCTGGCCGAGGCGGACATCGTCTCCCTGCACTGCCCGCTGACGCGCGACACGC
ATCACATGATCGACCGTGCCGCGCTGGCGCGGATGAAGCGCGGCGTGATGCTGATCAATACGGGGCGCGGGGCGCTCGTC
GATACCGCGGCGCTGATCGAGGGTTTGAAATCAGGGGTGATCGGCGATCTTGGCCTCGACGTCTACGAGGAGGAAGGCGG
CCTCTTCTTCGAGGATCTGTCGAACCAGATCATCCGGGACGACGTCTTCTCGCGCCTGCTGACCTTCCCGAACGTGATCG
TGACGGGGCATCAGGCCTTCTTCACCGCCGAGGCGCTGGCGGCGATTGCCGCGACCACCATCGAGAACCTGTCCTGCTTC
GAGAAGCAGGGTGTTCCGCGGCATCCCGTATCGGTTGAGCGCCTCGCCTGA

Protein sequence :
MDVTIFSTKAYDRRFLDEANAAAGEPHRLRYLEARLTHESAPLTQGARAVCAFVNDVLDRPVLGVLAASGTRMVALRSAG
FNNVDLPAAVELGIAVGRVPAYSPDAVAEHTVALILALNRKTHRAYARVREGNFALEGLLGFDLKGRTVGIVGTGKIGRA
VARILAGFGCRVLAYDPVPSAELAGFGAEAAGLDRLLAEADIVSLHCPLTRDTHHMIDRAALARMKRGVMLINTGRGALV
DTAALIEGLKSGVIGDLGLDVYEEEGGLFFEDLSNQIIRDDVFSRLLTFPNVIVTGHQAFFTAEALAAIAATTIENLSCF
EKQGVPRHPVSVERLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
EF2295 NP_815952.1 D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 2e-36 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mext_4349 YP_001641789.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase NC_014475.1.orf2.gen Protein 1e-34 43
Mext_4349 YP_001641789.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase NC_005054.2598279.p0 Protein 1e-34 43
Mext_4349 YP_001641789.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase AF130997.1.orf3.gene Protein 2e-40 42
Mext_4349 YP_001641789.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase U35369.1.gene5.p01 Protein 3e-37 42
Mext_4349 YP_001641789.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase AF310956.2.orf4.gene Protein 6e-36 41