Gene Information

Name : merA (ACL_0780)
Accession : YP_001620771.1
Strain : Acholeplasma laidlawii PG-8A
Genome accession: NC_010163
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 816133 - 817767 bp
Length : 1635 bp
Strand : -
Note : this protein contains a single copy of the Heavy-Metal-Associated (HMA) domain

DNA sequence :
ATGAAAAAACTTAAGATGAAAATACAAGGGATGACTTGTAAAGGTTGCGAGGGTCACATAGTGGAAGCACTTGAAAAAAT
AGGTGCAATAAATGTTAAAGCAAGTTTTCACAATGGAGAAGCAATATTTGAACTTCCAAAAGATACTGATGTCGAACTTT
CAAAAATTGCGATAAATAATATTAAGTATCAAGCTGGAATGATAGAAGAAGTATCCTTTAATAAAAACGATAGTGAGGAT
AAGATTTATGATCTTATTATAATTGGATCTGGGGCTGCTGCTTTTTCTGCGGCAATTAAAGCAATAGAATACGGTGCAAC
AGTTGCTATTGTTGAACGTGGGGAAGTTGGAGGGACTTGTGTAAATGTAGGTTGCATTCCATCAAAAACGCTTCTTAGAG
CAGGAGAAATCAATCAAGCAGCAAAGTCTAATCCATTCATTGGCTTAAAAACAAATGCTCAAAAAGTGGATTTAGCAACT
TTAGTAAAACAAAAAGATGAATTAGTCAATGAGCTTCGTAGTCAGAAATATATAAATTTAATCGATGAATACGGTATTGA
TTTAGTTAAAGGTGAAGCGAGATTTATTAATAAAACAACAATTGAAGTTAATGATAATAGATATATTGCAAAAAATTATT
TAATTGCTACTGGAGCATCGTCTTATATACCTAAAATTCATGGACTTGAATTTGTTGATTATTTAACAAGCACAACATTA
CTTGATTTAAAAGAAACACCAAGACGATTAACAGTGATTGGATCAGGATATATTGGATTAGAACTGGGGCAACTTTTTCA
TAATTTAGGTTCAAAAGTCACGATTATCCAAAGGGGAAAACAACTTCTGAAAGACTATGATCCTGAAATTTCAGATACTG
TCGAAAAATCATTGATTGAACAAGGTATAGAACTTATTAAAGGTGTAGCTTACGAACGAATAGAACAAATTGGTGATATC
AAAAAGGTTTATATTACAGTTGATGGTAAAAATGAGATTATTGAATCAGAACAATTATTGATTGCAACAGGAAGAAAACC
TAATACAGACACTTTAAATTTAAGTGCTGCAGACGTTAATGTAGGAGAAAGCAATGAAATTATAATAGATGATTATGGAA
GAACGAGTAACAATAAAATCTATGCAGCTGGAGATGTTACTTTAGGACCACAATTTGTCTATGTGGCAGCATATGAAGGT
GGAATTGTTGCAGACAATGCTATAGGCGGATTAAATAAAAAAATCGATTTATCGACTGTACCTGCAGTTACTTTTACAAA
CCCAGCAATTGCAACCGTTGGATTAACAGAGAAAGAAGCTAAAAATATAGGCTATGAAGTAAAAACTTCTGTAATCAATT
TAAATTTAGTCCCCAGAGCAATAGTAAATCGTGAAACAACCGGCATATTTAAGTTGGTTGCAGATACAAGAACACATAGA
ATACTAGGTGCACATATTGTATCTGAAAATGCAGGAGATGTTATTTATGCAGCATTACTAGCGGTAAAACATGGACTTAC
TATTGAAAATCTTATAGATAGTCTTGCTCCATATTTAACAATGGCCGAGGGGTTAAAATTAGCAGCACTAGCGTTTGATA
AAGATGTTTCAAAATTATCTTGTTGTGCAGGATGA

Protein sequence :
MKKLKMKIQGMTCKGCEGHIVEALEKIGAINVKASFHNGEAIFELPKDTDVELSKIAINNIKYQAGMIEEVSFNKNDSED
KIYDLIIIGSGAAAFSAAIKAIEYGATVAIVERGEVGGTCVNVGCIPSKTLLRAGEINQAAKSNPFIGLKTNAQKVDLAT
LVKQKDELVNELRSQKYINLIDEYGIDLVKGEARFINKTTIEVNDNRYIAKNYLIATGASSYIPKIHGLEFVDYLTSTTL
LDLKETPRRLTVIGSGYIGLELGQLFHNLGSKVTIIQRGKQLLKDYDPEISDTVEKSLIEQGIELIKGVAYERIEQIGDI
KKVYITVDGKNEIIESEQLLIATGRKPNTDTLNLSAADVNVGESNEIIIDDYGRTSNNKIYAAGDVTLGPQFVYVAAYEG
GIVADNAIGGLNKKIDLSTVPAVTFTNPAIATVGLTEKEAKNIGYEVKTSVINLNLVPRAIVNRETTGIFKLVADTRTHR
ILGAHIVSENAGDVIYAALLAVKHGLTIENLIDSLAPYLTMAEGLKLAALAFDKDVSKLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 3e-164 63
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 5e-164 63

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_001620771.1 mercuric reductase BAC0224 Protein 8e-174 65
merA YP_001620771.1 mercuric reductase BAC0651 Protein 2e-164 63
merA YP_001620771.1 mercuric reductase BAC0650 Protein 4e-78 43