Gene Information

Name : mxcE (sce3880)
Accession : YP_001614520.1
Strain : Sorangium cellulosum So ce 56
Genome accession: NC_010162
Putative virulence/resistance : Virulence
Product : (2,3-dihydroxybenzoyl)adenylate synthase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 5399428 - 5401086 bp
Length : 1659 bp
Strand : +
Note : High confidence in function and specificity

DNA sequence : 
ATGAGCGCTCCGGAGGAGAGCCGGCAGGCGCGACCGCAGGCGCTCGACGGCTGGACTCCCTGGCCGGCCGAGATGGCCGA
TCTCTACCGGCGCGCCGGCTACTGGCGCGGCGAGACCCTCGGGCGCCTGCTCCGCGAGCGGGCCGCGCGTCACCCGGATC
GGATCGCGCTCGTCAGCGGCGATCGCCGGCTGAGCTACGGGGAGCTCGATCGGCGCGCCGATCGCCTCGCCGCGGGCCTG
CTGCACCTCGGGCTCCGGCCGGGGGATCGCGTCGTCGTCCAGCTCCCGAACATCGCGGAGTTCTTCGAGGTGTGCTTCGC
GCTGTTCCGGCTCGGGGCGCTCCCCGTACTGGCCCTGCCCGCGCACCGGCGCGCCGAGATCGCGTACTTCTGCGAGCACA
CCGAGGCGGTCGCGTACGTCATCGCCGACCGGGACGGCGGGTTCGATTACCGCGCGCTGGCGAGCCAGATCCGGCGCGAC
GTCGGGACCTTGCGGCACGTGCTCGTGGCCGGCGAGCCGGGCGAGCACACGGCGCTCTCCAGCCTGGACCGGGAGCCCGT
CGAGCTCCCGGAGCCCGCCGCGGGGGACGTCGCGTTCTTCCAGCTGTCCGGCGGGAGCACCGGCGTACCGAAGCTCATCC
CGCGGACGCACGACGACTACCTCTACAGCGTGCGGGCCAGCGCGGAGATCTGCGGGCTCGACGAGGGCAGCGTTTACCTC
GCCGTCCTCCCCGTCGCGCACAACTTCACGCTCAGCTCACCCGGGAGCCTGGGCGTGCTCCACGCCGGCGGCCGCGTGGT
GCTCTGCCGCCGCCCCAGCCCGGACGAGGCGTTGCCGTGGATCGAGCGGGAGCGGGTCACGATGACCGCGCTCGTGCCGC
CGCTGGCCTCGGTCTGGCTGGAAGCGGCCCGGGCGGCGCGGCACGACCTGTCGAGCTTGAAGGTGCTCCAGGTGGGCGGC
GCCAGGCTCCCCGCGGAGGTCGCGCGCCGCGTGGGGCCGGCCCTGGGCTGCAAGGTGCAGCAGGTGTTCGGGATGGCGGA
GGGGCTCGTGAACTACACCCGCCTCGACGACCCCGACGCCATCGCGCTCGAGACGCAGGGGCGGCCCATCTCGCCCCACG
ACGAGGTCCGCGTCGTGGACGACGACGACCGCGACGTCGAGCCCGGGCAGGTCGGTCACCTGCTCACGCGAGGGCCCTAC
ACGATCCGCGGCTATTACAGGGCCGACGCGCACAACGAGAAGGCCTTCACGCGCGACGGCTTCTACCGCACGGGCGATCT
CGTGCGGCGGACCCGAGAGGGCTACCTCGTCGTGGAGGGCCGCGCCAAGGATCAGATCAACCGCGGCGGCGAGAAGATCG
CGGCCGAGGAGGTCGAGAACCACGTCCTCGCCCACCCGGCGGTGCGCGACGCGGCGCTCGTCGCCATGCCGGACGCCCAC
CTCGGCGAGCGCTCGTGCGCGTTCCTCGTGGCCCGCGGGCAGCCGCCGCCGGCGAGGGAGATCAACGCCTTCCTGCGCGA
GCGCGGCGTCGCCCAGTTCAAGGTGCCCGATCGCATCGAGTGGCTCGACGCCCTCCCGACGACGAGCGTCGGCAAGGTGG
ACAAGAAGGCGCTCCGCCGGTGGATCGCCGACAGGCTCGCGCAGGGCGCGCGCGCCTGA

Protein sequence : 
MSAPEESRQARPQALDGWTPWPAEMADLYRRAGYWRGETLGRLLRERAARHPDRIALVSGDRRLSYGELDRRADRLAAGL
LHLGLRPGDRVVVQLPNIAEFFEVCFALFRLGALPVLALPAHRRAEIAYFCEHTEAVAYVIADRDGGFDYRALASQIRRD
VGTLRHVLVAGEPGEHTALSSLDREPVELPEPAAGDVAFFQLSGGSTGVPKLIPRTHDDYLYSVRASAEICGLDEGSVYL
AVLPVAHNFTLSSPGSLGVLHAGGRVVLCRRPSPDEALPWIERERVTMTALVPPLASVWLEAARAARHDLSSLKVLQVGG
ARLPAEVARRVGPALGCKVQQVFGMAEGLVNYTRLDDPDAIALETQGRPISPHDEVRVVDDDDRDVEPGQVGHLLTRGPY
TIRGYYRADAHNEKAFTRDGFYRTGDLVRRTREGYLVVEGRAKDQINRGGEKIAAEEVENHVLAHPAVRDAALVAMPDAH
LGERSCAFLVARGQPPPAREINAFLRERGVAQFKVPDRIEWLDALPTTSVGKVDKKALRRWIADRLAQGARA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 7e-102 53
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-102 53
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-102 53
ybtE CAA21394.1 - Virulence HPI Protein 7e-102 53
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 7e-102 53
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 6e-101 53
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 5e-102 53
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-101 53
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-102 53
irp2E YP_005134497.1 siderophore biosynthetic protein Virulence Not named Protein 7e-74 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mxcE YP_001614520.1 (2,3-dihydroxybenzoyl)adenylate synthase VFG0168 Protein 8e-128 58
mxcE YP_001614520.1 (2,3-dihydroxybenzoyl)adenylate synthase VFG0932 Protein 3e-112 50
mxcE YP_001614520.1 (2,3-dihydroxybenzoyl)adenylate synthase VFG1817 Protein 1e-101 49