Gene Information

Name : thiC (NMCC_0147)
Accession : YP_001598318.1
Strain : Neisseria meningitidis 053442
Genome accession: NC_010120
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 147223 - 149124 bp
Length : 1902 bp
Strand : +
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGACTACGCCAAAAAAAACTGCCAAAACTTCCGGCAACGAAGCACGCGAGCTTGCCGACTTGAGCGAAGACATCGGCAT
CCGCTTCAAATATCCGAACTCGGAACGCGTGTATCTGCAAGGCAGCCGCGACGACATCCGCGTGCCTTTGCGCGAAATCC
GCCAGGACGACACCTACACGGCGCAAGGCACGGAAGCCAATCCGCCGATTCCCGTCTATGACACCAGCGGCGTGTACGGC
GATCCGGCGGCACACATCGATTTAAAACAAGGGCTGCCCCACATCCGCACGGCGTGGCTGGACGAACGCGGCGATACCGA
AATCCTGCCCAAACTCTCCAGCGAATACGGCATCGAACGCGCGCACGACCCGAAAACCGCCCATCTGCGTTTCAACCAAA
TCACCCGCCCGCGCCGCGCCAAAGCCGGACGCAACGTAACCCAATTACATTATGCCCGGCAAGGCATTATCACGCCCGAA
ATGGAGTTTGTCGCCATACGCGAACGTTTAAAATTAGACGAATTGTCCCAAAAACCGGAATACGCCAAGCTCTTGAAACA
ACACGCAGGGCAAAGTTTCGGCGCGAATATCCCGACCCATCCCGACCAAATCACGCCTGAATTCGTGCGCCGAGAAATCG
CCGCCGGACGCGCGATTATTCCCGCCAACATCAACCACCCCGAACTCGAACCGATGATTATCGGCCGCAACTTCCGCGTC
AAAATCAACGGCAATTTGGGCAACTCCGCCGTCACCTCCAGCCTGACCGAAGAAGTCGAAAAAATGGTGTGGTCGCTGCG
TTGGGGCGCGGACACGATTATGGATTTGTCCACCGGCGCGCACATCCATGAAACGCGCGAATGGATTATCCGCAACGCGC
CCGTCCCCATCGGCACCGTGCCGATTTACCAAGCGTTGGAAAAAACCGGCGGCATCGCCGAAGATTTGACTTGGGATTTG
TTCCGCGACACCCTCATCGAACAGGCGGAACAAGGCGTGGACTATTTCACCATACACGCGGGCGTGTTGCTGCGTTATGT
ACCGATGACCGCCAACCGCCTCACCGGCATCGTCTCGCGCGGCGGTTCGATTATGGCGAAATGGTGTTTGGCACATCATC
GGGAAAACTTCCTCTACACGCATTTCGACGAAATCTGCGAAATTATGAAAGCGTATGACGTATCGTTCAGCCTCGGCGAC
GGCCTGCGCCCCGGCTGCATTGCCGATGCCAACGACGAATCCCAATTCGCCGAGCTGCACACCTTGGGCGAATTGACCTC
CAAAGCGTGGAAACACGACGTACAGGTGATGATCGAAGGCCCCGGCCATGTACCGCTGCAACGCGTCAAAGAAAATATGA
CCGAAGAGTTGCAACACTGTTTTGAAGCACCGTTTTACACCCTCGGCCCGCTCGTTACCGACATCGCCCCCGGCTACGAC
CACATCACCTCGGGCATAGGCGCTGCCAATATCGGCTGGTACGGCACGGCGATGCTCTGTTACGTTACCCCCAAAGAACA
TTTGGGACTGCCCGACAAAGAAGACGTGCGTACCGGCATCATCACCTACAAACTCGCCGCCCACGCCGCCGACCTCGCCA
AAGGCTGGCCGGGCGCACAGTTGCGCGACAACGCCCTGAGCAAGGCGCGTTTCGAGTTCCGCTGGCGCGACCAGTTCCGC
CTAAGCCTCGACCCCGAACGCGCCGAAAGCTTCCACGACGAAACCCTGCCCGCCGAAGGCGCGAAAATCGCCCACTTCTG
TTCGATGTGCGGCCCCAAATTCTGCTCGATGAAAATCACGCAGGAAGTGCGCGACTACGCCGACAAGCAAAAAGCCCAAC
GGCAGGGCATGGAGGAAAAAGCGGTCGAGTTCGTCAAAAAAGGCGCGAAGATTTACAGTTGA

Protein sequence :
MTTPKKTAKTSGNEARELADLSEDIGIRFKYPNSERVYLQGSRDDIRVPLREIRQDDTYTAQGTEANPPIPVYDTSGVYG
DPAAHIDLKQGLPHIRTAWLDERGDTEILPKLSSEYGIERAHDPKTAHLRFNQITRPRRAKAGRNVTQLHYARQGIITPE
MEFVAIRERLKLDELSQKPEYAKLLKQHAGQSFGANIPTHPDQITPEFVRREIAAGRAIIPANINHPELEPMIIGRNFRV
KINGNLGNSAVTSSLTEEVEKMVWSLRWGADTIMDLSTGAHIHETREWIIRNAPVPIGTVPIYQALEKTGGIAEDLTWDL
FRDTLIEQAEQGVDYFTIHAGVLLRYVPMTANRLTGIVSRGGSIMAKWCLAHHRENFLYTHFDEICEIMKAYDVSFSLGD
GLRPGCIADANDESQFAELHTLGELTSKAWKHDVQVMIEGPGHVPLQRVKENMTEELQHCFEAPFYTLGPLVTDIAPGYD
HITSGIGAANIGWYGTAMLCYVTPKEHLGLPDKEDVRTGIITYKLAAHAADLAKGWPGAQLRDNALSKARFEFRWRDQFR
LSLDPERAESFHDETLPAEGAKIAHFCSMCGPKFCSMKITQEVRDYADKQKAQRQGMEEKAVEFVKKGAKIYS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 0.0 100
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 72
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 72