Gene Information

Name : thiC (COXBURSA331_A0437)
Accession : YP_001596278.1
Strain : Coxiella burnetii RSA 331
Genome accession: NC_010117
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 373106 - 374752 bp
Length : 1647 bp
Strand : +
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGCGGCTGCATCGCACTTTCCTTCTGCGTGTTTATTTGAAGGAGAGTGCTGTGATTACTTATCCTGCTTCCAAAAAGAT
TTATTGCCAAGGCAAGATTTTCCCCACTATTCGCGTAGGAATGCGTGAAATTCAATTGACGAACGGTGATTCGCTAACCC
TTTACGATACCTCAGGTCCGTATTCTGACCCGAATATCTCTATCAAATCGCCGCAGGGACTTCCCCGCTTGCGCGAGCCT
TGGATTAAAGTGCGCCCGAGGAAAACGCAATTGGCTTTCGCAAAAGAAGGCGTCATTACACCAGAAATGGAATACGCTGC
GATTCGTGAAAATCAAAAAAGAGAGTTGAAGAAAAACACGGATCAAGAACGCAAACGTCGTTTGCAAGGAAATTCGTTGA
GTGCGCGAATTCCTAACCCAATTACGCCGGAATTTATTCGAAATGAAATCGCGTGCGGTCGTGCCATCTTGCCTGCGAAT
ATTAATCATCCCGAAAGCGAGCCTATGATTATTGGTCGCCATTTTTTAGTTAAAGTAAACGCGAATATTGGGAACTCGTC
GCTTACGTCATCTGTGGAGGAAGAAGTTGAAAAATTAATTTGGGCATTGCGTTGGGGGGCGGATACGGTGATGGATCTAT
CGACGGGAAAAAAAATCAAAGAAATTCGTGAAACAATTCTTCGTCATTCTCCGGTACCTATCGGTACCGTGCCGTTGTAT
GAAGCATTGGAAAAAGTGGATGGAGATGTAAAAGCCCTAACCTGGGAAATTTTCCGCGACACCTTAATTTCGCAAGCTGA
ACAAGGAGTTGATTATTTCACGATTCATGCAGGTGTTTTAAATCGTTTTATTCCATTGACCCAAAAACGCGTCACGGGAA
TTGTTTCTCGCGGTGGCTCTCTCATGGCCAAATGGTGTCTTTTGCACCGAGAGGAGAATTTTCTTTATACGCATTTTACT
GAGATTTGTGAAATTATGCGCGCTTATGATGTGAGCTTTTCGCTAGGGGATGGGTTGCGCCCAGGCTCTATTGCTGATGC
CAATGATGAAGCGCAATTTGCAGAATTGAAAATTCAAGGCGAATTAAATCGCATTGCGTGGAAATACGGTGTGCAGGTGA
TGAATGAAGGACCAGGGCATATCCCTCTAAACCTCATCGAAGAAAATATGACGAAACAGTTGGCTTATTGCCGGGAAGCG
CCATTTTATACCCTGGGACCATTAACTACCGATATTGCGCCTGGTTATGATCATATCGGTAGCGCTATTGGCGCTGCTTT
TATCGCTTGGCAAGGGTGCGCGCTCTTGTGCTATGTCACGCCGAAAGAACATTTGGGATTACCGAACAAACAAGACGTCA
AAGAAGGACTGATTGCTTATAAAATTGCGGCCCATGCCGCAGATTTAGCAAAAGGACACCCAGCGGCTCGACAGCGAGAT
TATTTATTATCGCAAGCGCGGTTTGAATTCCGCTGGCACGATCAATTTAATTTAGCGTTAGACGCTGAAACAGCGCGCCT
TTTTCATGATGAGACTTTGCCAAAAGAGGCTGCTAAACACGCTCATTTTTGTTCATTGTGCGGCCCTAAATTTTGCGCTT
ACAAAACGAGCCACGAGGTTAGGGATACCTTACAAAAGGTAACGTAA

Protein sequence :
MRLHRTFLLRVYLKESAVITYPASKKIYCQGKIFPTIRVGMREIQLTNGDSLTLYDTSGPYSDPNISIKSPQGLPRLREP
WIKVRPRKTQLAFAKEGVITPEMEYAAIRENQKRELKKNTDQERKRRLQGNSLSARIPNPITPEFIRNEIACGRAILPAN
INHPESEPMIIGRHFLVKVNANIGNSSLTSSVEEEVEKLIWALRWGADTVMDLSTGKKIKEIRETILRHSPVPIGTVPLY
EALEKVDGDVKALTWEIFRDTLISQAEQGVDYFTIHAGVLNRFIPLTQKRVTGIVSRGGSLMAKWCLLHREENFLYTHFT
EICEIMRAYDVSFSLGDGLRPGSIADANDEAQFAELKIQGELNRIAWKYGVQVMNEGPGHIPLNLIEENMTKQLAYCREA
PFYTLGPLTTDIAPGYDHIGSAIGAAFIAWQGCALLCYVTPKEHLGLPNKQDVKEGLIAYKIAAHAADLAKGHPAARQRD
YLLSQARFEFRWHDQFNLALDAETARLFHDETLPKEAAKHAHFCSLCGPKFCAYKTSHEVRDTLQKVT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 2e-167 64
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 2e-167 64
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 4e-156 60