Gene Information

Name : guaA (Nmar_1573)
Accession : YP_001582907.1
Strain : Nitrosopumilus maritimus SCM1
Genome accession: NC_010085
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1440119 - 1441642 bp
Length : 1524 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGACAAGATTGTAGTTTTAGATTTTGGATCACAGTATAGTCATTTGATTTGTAGAAGAATAAGAGAATTTTCAGTATA
TGCAGAACTAGTTCCTTTTGATATTAGCTATGAAGAGTTGCAAAAACACAATCCAAAAGGAATAATTTTTTCAGGCGGTC
CATCTAGTGTTTATAGTTCTGATGCACCAGTTCCAGAAAGTAAAATTTTTGATATGAATTTACCGTTACTTGGAATTTGT
TACGGTCATCAATTAATTGTAAACAAGTACGGAGGTAAAGTAAAAAGAGCAAACAAAGAATACGGTTCCTCATTACTAAC
AATTGACAATGATAAAGATTTGCTAAATGGTGTCGGTGAATCAGTAAGGGCATGGATGAGTCACGGGGATGAAGCTGAAG
AAATTCCTCCAGGATTCCAAGTCATAGGACATACAGAAAGTGCAAAAGCAGCTGCAATAGCATCAGATGAAAAATCAGTT
TATGGAATTCAATTCCATCCAGAAGTTGTTCACACAGAACAAGGTACAGAAATTCTCAAAAATTTTGTGTTAAAAGTTTG
TGGGGCAAAACAAGACTGGACAATGGAGGGTTTTATCGATTCGGCAGTAGAAAAAATCTCAAAAATTGAGGGTAACGTGC
TTTGTGGAGTCAGCGGAGGCATAGATTCCACTGTAGCGGCATTGTTAATTCACAAAGCCATAGGAGACAGACTCAAGTGT
GTTTTTGTCAATAATGGATTGCTTAGACTAAACGAAGAAACAGAGATTGAAACTATGTTCAAAGATAATTTCAATGTAAA
TTTTACATCAATTAACGCAGTAGATAGTTTTCTTGACAAGCTCAAAGGAGTTGAAGACCCAGAAAAGAAGAGAAAGATTG
TTGGTGAAGAATTTGTTAATGTATTTACAGAATTTGCTGAAAAGAACGGTCCATTCAAATGGTTAGCTCAAGGAACTCTA
TATCCAGATGTGATTGAAAGCGGAGTTTCAAAAGGACCAGCTGATGTAATAAAATCACATCACAATGTAGGAGGACTACC
TGACTGGCTCAATTTAGAAATTTTAGAGCCATTAAGAGAACTATACAAAGATGAAGTAAGAATGATTGCAAAAATTCTTG
AAGTTCCAGAAAAACTTTTCATGAGACATCCTTTCCCAGGACCAGGATTGGCTGTAAGAATCATCGGAGAAGTTACACCA
ACAAAACTCCAAATCTCAAAAGTTGCAAGTAAAATTGTAGAAGACGAACTAGTTGAAGCCGGTCTGTATGGAAAAGTTTG
GCAAGCTTATGCAGCAGTAGGAGATGATAGGGCAGTAGGTGTTGTTGGAGATGAGAGAAAATACGGAAATATTGTAATGA
TCAGAGTTGTTGATTCAATTGATGCAATGACTGCAGATTGGACAAGATTACCACACGGATTGTTAGAAAAGATGAGCAAC
AGAATAACAAATGAGATTGAAGATGTAACTTGGGTGACATATACTATATCAAGCAAGCCTCCTGCCACAATTGAGCCTCA
ATAG

Protein sequence :
MDKIVVLDFGSQYSHLICRRIREFSVYAELVPFDISYEELQKHNPKGIIFSGGPSSVYSSDAPVPESKIFDMNLPLLGIC
YGHQLIVNKYGGKVKRANKEYGSSLLTIDNDKDLLNGVGESVRAWMSHGDEAEEIPPGFQVIGHTESAKAAAIASDEKSV
YGIQFHPEVVHTEQGTEILKNFVLKVCGAKQDWTMEGFIDSAVEKISKIEGNVLCGVSGGIDSTVAALLIHKAIGDRLKC
VFVNNGLLRLNEETEIETMFKDNFNVNFTSINAVDSFLDKLKGVEDPEKKRKIVGEEFVNVFTEFAEKNGPFKWLAQGTL
YPDVIESGVSKGPADVIKSHHNVGGLPDWLNLEILEPLRELYKDEVRMIAKILEVPEKLFMRHPFPGPGLAVRIIGEVTP
TKLQISKVASKIVEDELVEAGLYGKVWQAYAAVGDDRAVGVVGDERKYGNIVMIRVVDSIDAMTADWTRLPHGLLEKMSN
RITNEIEDVTWVTYTISSKPPATIEPQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-120 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-120 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-120 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-112 46