Gene Information

Name : guaA (lhv_0258)
Accession : YP_001576789.1
Strain : Lactobacillus helveticus DPC 4571
Genome accession: NC_010080
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 262776 - 264260 bp
Length : 1485 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGATTACTCGACGCATTCGTGACTTCGGTATTTATTCAGAACTTTTACCTCACGATCTTTCTATTGCCAAGATTAAAGA
AATGCATCCCAAGGGCATTATTTTTTCTGGTGGTCCTAACAGTGTTTATGATGATGGTGCATTAAAAGTAGATCCAGAAA
TCTTCAAGTTGGGTATCCCAATTTTAGGTATTTGTTATGGAATGCAGCTCATGTCATATGACTTAGGCGGTAAGGTTGAA
CAGGCTGAGAACAAAGAATATGGTCGTGCTAATATTACCGTTGAAGATCCTGATAGTGCATTGTTTAAGGGCCTGCCAAG
TAAGCAATATGTTTGGATGAGTCATGGTGATTTGGTAACTAAGGCTCCTAACGGCTTTGAGGTAGCTGCTTCAAGCAAGA
ACTGTCCAATTGCTGCTATTGCTAATCCAGATAAAAAGTTTTACGGTATTCAATTCCACGCAGAAGTACGTAATTCAGAA
TATGGTTTAGACATCTTGAAGCACTTTGCCTTTGATGTTTGTGGTGCTGATGCTAACTGGACCATGAACGACTTTATCGA
CATGAAGGTTGACGATATTCGTAAAGAAGTTGGCGACAAGAAGGTTATCTTAGGACTTTCAGGCGGTGTGGATTCCAGCG
TTACTGCTACTCTTTTACACAAAGCAATTGGCGATCAATTGACTGCAATTTTCGTTGATCACGGGATGCTGCGTAAAGAT
GAAGGCGACCAAGTAATGCAAGCCTTGAATAAGGATCTTGGCGTCAACATTATTCGCGTTAACGCACAAAAGAGATTTTT
GGACAAGTTAAAGGGTGTTACTGATCCTGAACAAAAGCGTAAGATCATCGGTAAGGAATTTATCGAAGTCTTCAATGAAG
AAGCTAAGAAGTTAAAGGATGTAAACTTCTTAGCTCAAGGTACGCTTTATACTGATGTCATTGAATCAGGGACTAACACT
GCCCAAACTATCAAGTCTCACCACAACGTTGGTGGCCTTCCTAAGGACATGCACTTCAAGTTAATTGAACCCCTTCGTAA
GTTGTTCAAGGATGAAGTTCGTGAACTTGGTGAAAGATTAGGCATTCCACATGACTTAGTATGGCGTCAGCCATTCCCAG
GTCCAGGTCTTGGTATTCGCGTGCTTGGCGAAGTTACAGAAGACAAGCTCAAGATTGTGCGTGATTCCGATGCGATTTTG
CGTGAAGAAATCAAGAAGGCTGGTTTGCAAGAAAAGATCTGGCAATACTTCACAGTTTTACCAGGTATTCGTTCAGTTGG
CGTTATGGGTGACGGCCGTACTTATGACTACACCATTGGTATTCGTGCCGTTACTTCAATTGATGGGATGACTGCTGATT
TTGCCCAAATTCCATGGGATGTACTTGGTCATATTTCAGATAGAATCGTCAATGAAGTAGATAACGTTAACCGTGTAGTC
TACGATGTGACGAGTAAGCCACCTTCAACTATTGAATGGGAATAA

Protein sequence :
MITRRIRDFGIYSELLPHDLSIAKIKEMHPKGIIFSGGPNSVYDDGALKVDPEIFKLGIPILGICYGMQLMSYDLGGKVE
QAENKEYGRANITVEDPDSALFKGLPSKQYVWMSHGDLVTKAPNGFEVAASSKNCPIAAIANPDKKFYGIQFHAEVRNSE
YGLDILKHFAFDVCGADANWTMNDFIDMKVDDIRKEVGDKKVILGLSGGVDSSVTATLLHKAIGDQLTAIFVDHGMLRKD
EGDQVMQALNKDLGVNIIRVNAQKRFLDKLKGVTDPEQKRKIIGKEFIEVFNEEAKKLKDVNFLAQGTLYTDVIESGTNT
AQTIKSHHNVGGLPKDMHFKLIEPLRKLFKDEVRELGERLGIPHDLVWRQPFPGPGLGIRVLGEVTEDKLKIVRDSDAIL
REEIKKAGLQEKIWQYFTVLPGIRSVGVMGDGRTYDYTIGIRAVTSIDGMTADFAQIPWDVLGHISDRIVNEVDNVNRVV
YDVTSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-169 68
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-169 68
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-169 68
guaA NP_938969.1 GMP synthase Not tested Not named Protein 7e-126 51