Gene Information

Name : SARI_00079 (SARI_00079)
Accession : YP_001569174.1
Strain : Salmonella enterica RSK2980
Genome accession: NC_010067
Putative virulence/resistance : Virulence
Product : ATP synthase SpaL
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : -
Position : 77019 - 78314 bp
Length : 1296 bp
Strand : +
Note : Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase

DNA sequence :
ATGAAAACACCTCGTTTACTTCAGTATCTGGCCTACCCACAAAAAATAACGGGCCCAATCATTGAGGCGGAGTTGCGCGA
TGTAGCTATTGGCGAGCTGTGTGAAATACGCCGTGGCTGGCACCAAAAACAGGTCGTTGCGCGTGCGCAGGTGGTTGGCT
TACAACGGGAACGCACCGTGCTGAGCCTTATCGGCAATGCCCAGGGGCTGACCCGCGATGTCGTGCTTTATCCTACTGGG
CGCGCGTTATCGGCGTGGGTGGGATATTCGGTATTAGGCGCGGTATTGGACCCGACGGGGAAAATCGTTGAGCGTTTTAC
CACTGAAGTAGCGCCGATTAGCGAAGAACGCGTTATTGATGTCGCACCGCCTCCTTACGCCTCGCGTGTTGGCGTCCATG
AACCGCTGATTACCGGCGTGCGTGCGATCGACGGGTTATTGACCTGTGGCGTAGGTCAGCGAATGGGCATTTTTGCCTCC
GCAGGATGTGGTAAGACCATGCTGATGCATATGCTGATCGAGCAAACAGAGGCGGATGTCTTTGTTATCGGTCTTATCGG
TGAACGAGGCCGTGAAGTCACTGAATTTGTGGATATGTTGCGCGCCTCGCATAAGAAAGAAAAATGCGTGCTGGTTTTTG
CCACCTCCGATTTCCCCTCGGTAGATCGCTGTAATGCGGCACAACTGGCGACAACCGTAGCGGAATATTTTCGTGACCAG
GGAAAAAGGGTCGTGCTCTTTATCGATTCTATGACCCGTTATGCGCGCGCTTTGCGAGACGTAGCTTTGGCGTCAGGGGA
GCGTCCGGCTCGACGCGGTTATCCGGCCTCCGTATTCGATAATTTGCCACGCCTGCTGGAACGCCCCGGCGCGACCGGCG
ATGGAAGCATTACCGCCTTTTATACGGTGCTGCTGGAAAGCGAGGAAGAGGCGGACCCAATGGCGGATGAAATTCGCTCT
ATTCTTGACGGACACCTGTATCTGAGCAGAAAGCTGGCAGGGCAGGGGCATTACCCGGCTATTGATGTACTGAAAAGCGT
AAGCCGCGTTTTTGGACAAGTCACAACGGCGACACATGCTAAGCAGGCGTCTTCTGTGCGTAAATTAATGACGCGTCTGG
AAGAGCTCCAGCTTTTCATTGACTTAGGCGAATATCGTCCTGGCGAAAATATTGATAACGATCGGGCGATGCAAATGCGC
GATAGCCTGAAAGCCTGGTTATGCCAGCCAGTAACGCAATATTCATCTTTTGATGACACATTGAGCGGTATGAATGCATT
CGCTGACCAGGATTAA

Protein sequence :
MKTPRLLQYLAYPQKITGPIIEAELRDVAIGELCEIRRGWHQKQVVARAQVVGLQRERTVLSLIGNAQGLTRDVVLYPTG
RALSAWVGYSVLGAVLDPTGKIVERFTTEVAPISEERVIDVAPPPYASRVGVHEPLITGVRAIDGLLTCGVGQRMGIFAS
AGCGKTMLMHMLIEQTEADVFVIGLIGERGREVTEFVDMLRASHKKEKCVLVFATSDFPSVDRCNAAQLATTVAEYFRDQ
GKRVVLFIDSMTRYARALRDVALASGERPARRGYPASVFDNLPRLLERPGATGDGSITAFYTVLLESEEEADPMADEIRS
ILDGHLYLSRKLAGQGHYPAIDVLKSVSRVFGQVTTATHAKQASSVRKLMTRLEELQLFIDLGEYRPGENIDNDRAMQMR
DSLKAWLCQPVTQYSSFDDTLSGMNAFADQD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 0.0 98
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 0.0 98
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 0.0 98
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 0.0 98
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 8e-132 64
invC AAS66861.1 InvC Not tested SSR-2 Protein 1e-131 62
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 1e-111 57
escN AAC38383.1 EscN Virulence LEE Protein 1e-72 49
escN CAC81862.1 EscN protein Virulence LEE II Protein 2e-71 48
escN CAI43874.1 EscN protein Virulence LEE Protein 2e-71 48
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 4e-71 48
escN AAK26715.1 EscN Virulence LEE Protein 6e-71 48
escN AAL57542.1 EscN Virulence LEE Protein 6e-71 48
escN YP_003223475.1 translocator EscN Virulence LEE Protein 2e-71 48
escN NP_290268.1 hypothetical protein Virulence LEE Protein 4e-72 48
escN AAC31513.1 L0034 Virulence LEE Protein 3e-72 48
ECs4568 NP_312595.1 EscN Virulence LEE Protein 4e-72 48
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 3e-72 48
escN YP_003236088.1 translocator EscN Virulence LEE Protein 2e-72 48
lscN AAO18044.1 LscN Virulence TTSS locus Protein 3e-84 47
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 5e-83 46
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 3e-71 46
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 2e-71 46
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-71 46
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-71 46
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 3e-71 46
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 9e-82 45
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 6e-82 45
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 9e-75 45
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 7e-83 44
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 7e-83 44
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-82 44
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 9e-83 44
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-81 44
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-81 44
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 8e-69 44
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 4e-69 44
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 2e-69 44
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 1e-71 44
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 1e-68 44
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 3e-59 43
unnamed AAL06369.1 EscN Virulence LEE Protein 7e-71 43
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 3e-62 42
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-70 42
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-70 42
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 2e-62 42
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 7e-64 41
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 6e-64 41
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 6e-61 41
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 6e-61 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG0555 Protein 0.0 98
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG2459 Protein 4e-118 59
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG1008 Protein 2e-120 58
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG1778 Protein 9e-108 58
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG0730 Protein 6e-73 49
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG0812 Protein 2e-72 48
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG0390 Protein 9e-88 46
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG0192 Protein 3e-83 46
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG0515 Protein 1e-71 46
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG0048 Protein 8e-83 45
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG2144 Protein 1e-68 42
SARI_00079 YP_001569174.1 ATP synthase SpaL VFG1254 Protein 9e-64 42