Gene Information

Name : guaA (SARI_00366)
Accession : YP_001569445.1
Strain : Salmonella enterica RSK2980
Genome accession: NC_010067
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 365137 - 366714 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAGACAATATTCATAAACATCGCATTCTCATCCTGGATTTCGGTTCCCAGTACACTCAGTTGGTGGCGCGTCGCGT
GCGTGAACTGGGCGTTTACTGCGAACTGTGGGCGTGGGATGTCACGGAAGCGCAGATTCGCGAATTTAATCCCAGCGGGA
TTATCCTTTCCGGCGGCCCGGAAAGCACCACTGAAGAAAATAGCCCGCGCGCGCCGCAGTATGTGTTTGAGGCGGGCGTG
CCGGTGTTTGGCGTCTGCTACGGTATGCAGACTATGGCGATGCAGCTTGGCGGTCATGTGGAAGGTTCTAATGAGCGTGA
ATTTGGCTATGCGCAGGTCGAAGTGCTGACCGATAGCGCACTGATTCGCGGTATTGAAGACTCTCTGACCGCTGACGGCA
AACCATTGCTGGATGTTTGGATGAGCCATGGTGATAAAGTGACGGCGATTCCGTCCGACTTTGTGACGGTTGCCAGCACT
GAAAGCTGCCCGTTCGCAATCATGGCGAACGAAGAAAAACGCTTCTACGGCGTGCAGTTCCACCCGGAAGTGACCCATAC
TCGTCAAGGGATGCGTATGCTGGAGCGTTTTGTACGCGATATTTGCCAGTGTGAAGCGTTGTGGACTCCGGCGAAGATCA
TCGACGATGCCGTAGCCCGCATTCGCGAGCAGGTAGGCGACGATAAAGTTATTCTCGGCCTCTCCGGCGGCGTGGACTCC
TCCGTCACCGCAATGCTGCTGCACCGCGCCATCGGTAAAAATCTGACCTGTGTTTTCGTCGATAACGGCCTGCTGCGCCT
CAACGAAGCCGAGCAGGTGATGGACATGTTTGGCGACCATTTTGGTCTGAACATTGTTCACGTACCGGCAGAAGATCGCT
TCCTGTCCGCGTTGGCTGGCGAGAACGATCCGGAAGCCAAGCGTAAGATCATTGGCCGTGTTTTCGTGGAAGTGTTCGAT
GAAGAAGCGCTTAAGCTGGAAGATGTGAAATGGCTGGCGCAGGGGACTATCTATCCTGATGTGATCGAATCTGCCGCCTC
CGCAACCGGTAAAGCGCATGTCATCAAATCTCACCACAATGTCGGCGGCCTGCCGAAAGAGATGAAGATGGGGCTGGTTG
AACCGCTGAAAGAGCTGTTCAAAGATGAAGTACGTAAGATTGGTCTGGAGCTGGGCCTGCCGTATGACATGCTGTATCGC
CATCCGTTCCCGGGGCCGGGCCTCGGCGTGCGCGTACTGGGCGAAGTGAAGAAAGAGTACTGTGACCTGCTGCGTCGCGC
AGACGCTATCTTCATTGAAGAGCTGCGCAAAGCGGATCTGTACGACAAAGTGAGTCAGGCGTTTACTGTCTTCCTGCCGG
TCCGTTCCGTAGGCGTCATGGGTGATGGGCGTAAGTACGATTGGGTGGTCTCCCTGCGTGCCGTCGAAACTATCGACTTT
ATGACCGCGCACTGGGCGCATCTGCCGTATGGCTTCCTGGGACGCGTTTCCAACCGCATCATCAATGAAGTCAACGGGAT
TTCCCGTGTGGTGTATGACATCAGCGGTAAACCACCGGCAACAATTGAGTGGGAATAA

Protein sequence :
MTDNIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGPESTTEENSPRAPQYVFEAGV
PVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALIRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVAST
ESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDS
SVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFD
EEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYGFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-127 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-127 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-128 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-110 47