Gene Information

Name : entE (SARI_02340)
Accession : YP_001571345.1
Strain : Salmonella enterica RSK2980
Genome accession: NC_010067
Putative virulence/resistance : Virulence
Product : enterobactin synthase subunit E
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 2263727 - 2265340 bp
Length : 1614 bp
Strand : -
Note : 'bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate

DNA sequence :
ATGATGCGTATACCTTTCACCCGTTGGCCGGATGAATTTGCCCGCCGTTATCGTGAAAAAGGCTACTGGCAAGACGTGCC
GTTGACCGACATTCTGACCCGCCACGCTGACAGCGACAAGACGGCGGTCATTGAAGGCGAGCGCGCATTCAGCTATCGCC
AGCTCAACCAGGCCGCGGATAATCTGGCCTGCAGTTTACGCCGTCAGGGCATCAAACCTGGCGAAACCGCTCTGGTGCAA
CTGGGGAATGTACCGGAACTGTATATCACCTTTTTCGCCCTGTTGAAGCTTGGCGTAGCGCCTGTTCTGGCGCTGTTTAG
CCATCAACGCACCGAACTTAACGCCTATGCGACGCAGATCGCGCCGACGCTGGTAATTGCCGATCGCCAACATACGCTGT
TCGCCGGGGAGGCCTTTCTCAACACGTTTGTGGCAGAGCACCGCTCTGTGCGGGTGGTATTATTGCGTAACGACGATGGC
GATCACAGCCTGGACGCGGCGATGCGTCAGACGGCGGAAGATTTCACCGCCACGCCATCACCTGCTGACGAGGTGGCCTA
CTTTCAGCTTTCCGGCGGTACTACCGGCACGCCAAAGCTTATTCCCCGTACCCATAACGACTATTACTACAGCGTGCGCC
GCAGCAATGAGATTTGCGGTTTCAACGAGGAGACGCGTTTTCTGTGCGCGATTCCCGCCGCGCATAACTACGCCATGAGT
TCGCCGGGCGCCCTGGGCGTCTTTCTCGCCAAAGGAACGGTAGTGCTGGCGACCGATCCCAGCGCCACGCTCTGTTTCCC
GCTGATCGAAAAACACCAGATTAATGCCACGGCGCTGGTGCCGCCAGCGGTCAGTCTATGGCTACAGGCTATCCAGGAGT
GGGGCGGCAATGCGCCACTGGCGTCATTAAGGTTATTGCAGGTTGGCGGCGCGCGGCTTTCCGCGACGCTGGCCGCCCGT
ATTCCGGCTGAAATTGGTTGTCAGTTGCAGCAGGTCTTCGGCATGGCGGAAGGGTTAGTGAACTATACCCGGCTGGACGA
TAGTCCGGAACGGATTATCCATACCCAGGGAAGACCCATGTGCCCGGACGACGAAGTGTGGGTGGCGGATGCCGACGGAA
ATCCTCTGCCGCCGGGCGAGATTGGCCGTCTGATGACGCGCGGCCCCTATACTTTCCGCGGCTATTTCAACAGTCCGCAA
CACAATGCCAACGCTTTTGACGCCAACGGCTTTTACTGTTCCGGCGATCTGATCTCCATTGATCAAGACGGTTACATCAC
CGTCCACGGACGTGAAAAAGATCAGATCAATCGGGGCGGCGAGAAGATAGCCGCCGAAGAGATAGAAAACTTGTTACTGC
GCCACCCGGCGGTGATCCATGCGGCGCTGGTCAGCATGGAAGATGAACTGCTGGGGGAAAAAAGTTGCGCATACCTGGTG
GTAAAAGAGCCGCTGCGTGCGGTACAGGTACGCCGTTTCCTGCGAGAGCAGGGAGTGGCGGAATTTAAATTACCGGATCG
CGTAGAGTGCGTTGCGTCACTGCCGCTGACGCCGGTTGGTAAAGTCGATAAAAAACAATTACGCCAGTGGTTGGTGTCCC
GTTCACCGCTCTGA

Protein sequence :
MMRIPFTRWPDEFARRYREKGYWQDVPLTDILTRHADSDKTAVIEGERAFSYRQLNQAADNLACSLRRQGIKPGETALVQ
LGNVPELYITFFALLKLGVAPVLALFSHQRTELNAYATQIAPTLVIADRQHTLFAGEAFLNTFVAEHRSVRVVLLRNDDG
DHSLDAAMRQTAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSNEICGFNEETRFLCAIPAAHNYAMS
SPGALGVFLAKGTVVLATDPSATLCFPLIEKHQINATALVPPAVSLWLQAIQEWGGNAPLASLRLLQVGGARLSATLAAR
IPAEIGCQLQQVFGMAEGLVNYTRLDDSPERIIHTQGRPMCPDDEVWVADADGNPLPPGEIGRLMTRGPYTFRGYFNSPQ
HNANAFDANGFYCSGDLISIDQDGYITVHGREKDQINRGGEKIAAEEIENLLLRHPAVIHAALVSMEDELLGEKSCAYLV
VKEPLRAVQVRRFLREQGVAEFKLPDRVECVASLPLTPVGKVDKKQLRQWLVSRSPL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-89 42
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-89 42
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-89 42
ybtE CAA21394.1 - Virulence HPI Protein 1e-89 42
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-89 42
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-89 42
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-89 42
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 2e-89 42
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-89 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
entE YP_001571345.1 enterobactin synthase subunit E VFG0932 Protein 0.0 87
entE YP_001571345.1 enterobactin synthase subunit E VFG0168 Protein 9e-117 46
entE YP_001571345.1 enterobactin synthase subunit E VFG1817 Protein 2e-90 41