Gene Information

Name : Cphy_1227 (Cphy_1227)
Accession : YP_001558344.1
Strain : Clostridium phytofermentans ISDg
Genome accession: NC_010001
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1549735 - 1550889 bp
Length : 1155 bp
Strand : +
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cbh:CLC_0782 cystathionine beta-lyase

DNA sequence :
ATGGACAAATTTAATAAGATTTCAACAACATTAATTCATGGAGGTATTGACGGAGATGAGAGAACTGGAGCAGTGAATGT
TCCAATCTATCAGACGTCAACTTATAAACAGGAAGGGTTAGGAAAGCATAAGGGATATGAATATTCGAGAACCGGAAATC
CCACTAGAGAAGCCCTTGAGAAACTTATTGCTGATTTAGAGGAAGGCTTATATGGGTTGGCATTTGCCTCAGGTATGGCA
GCCACGACAGCTGTTTTAACCTTATTTGAAACGGGTGACAAGATATTAATATCAAAAAATGTGTATGGTGGAACCTTCCG
AGTGCTAGATAAAATTTTTAGTCAGTTTGGTATCCATTATGAGATCGTAGATACGAATGATTTAGAACTTCTTGAAAATT
CTTTGTCTGAAGAAGTTAAGGCTGTATTTATTGAAAGCCCTGCAAATCCTTTAATGACAGTAACGGATATTAAAGCCGTA
TCGGAAGTTACTAAAAAGCAGGGGAAATTATTAATCGTTGATAACACATTTATGACTCCGTATTTACAACGCCCTCTGAC
ACTTGGAGCTGACATTGTAGTCCATAGTGCAACAAAGTACTTAGGTGGGCATAGTGATCTTATTGCAGGGCTAGCTGTTG
TAAATGATGATGCTCTGGCAAAAAAATTATACTTTATACAGAATGCAACAGGGGGAATTCTTCAACCGTTTGATGCCTTT
TTGTTAATACGTGGAATGAAAACTCTAGGGGTTAGGCTAGACCGCCATCAGGAGAATGCAAAGGCTGTAGCGGAGTGGCT
TTTAGATCAAGATGCAGTAAAAAATGTATATTATCCGGGGCTGACAACATTTGAAGGCTATGAAATCCAGAGGAAGCAAG
CAGACGGACCGGGTGCTATGATATCCTTTGAATTGAACGAGGGGTATCATATCGAAAAGTTTTTTGGTGAATTAAAGCTG
ATAACACTAGCAGAAAGCCTTGGCGGTGTAGAATCACTAGTATGCCATCCAGCCAGCATGACACATGCGTCGATACCGGA
GGAAATAAGAAAGCAAGTTGGAATATCAAATCAATTAATCCGCCTCTCGGTTGGAATTGAAAACAAAGAAGATATTATTG
CAGACCTTAAGAATGCAATACTTTTAGCTAAATAA

Protein sequence :
MDKFNKISTTLIHGGIDGDERTGAVNVPIYQTSTYKQEGLGKHKGYEYSRTGNPTREALEKLIADLEEGLYGLAFASGMA
ATTAVLTLFETGDKILISKNVYGGTFRVLDKIFSQFGIHYEIVDTNDLELLENSLSEEVKAVFIESPANPLMTVTDIKAV
SEVTKKQGKLLIVDNTFMTPYLQRPLTLGADIVVHSATKYLGGHSDLIAGLAVVNDDALAKKLYFIQNATGGILQPFDAF
LLIRGMKTLGVRLDRHQENAKAVAEWLLDQDAVKNVYYPGLTTFEGYEIQRKQADGPGAMISFELNEGYHIEKFFGELKL
ITLAESLGGVESLVCHPASMTHASIPEEIRKQVGISNQLIRLSVGIENKEDIIADLKNAILLAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-87 50
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 9e-89 50
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-61 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Cphy_1227 YP_001558344.1 cystathionine gamma-synthase BAC0207 Protein 4e-69 45